Conserved Protein Domain Family
LIM3_Lrg1p_like
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cd09393: LIM3_Lrg1p_like 
The third LIM domain of Lrg1p, a LIM and RhoGap domain containing protein
The third LIM domain of Lrg1p, a LIM and RhoGap domain containing protein: The members of this family contain three tandem repeats of LIM domains and a Rho-type GTPase activating protein (RhoGap) domain. Lrg1p is a Rho1 GTPase-activating protein required for efficient cell fusion in yeast. Lrg1p-GAP domain strongly and specifically stimulates the GTPase activity of Rho1p, a regulator of beta (1-3)-glucan synthase in vitro. The LIM domain is 50-60 amino acids in size and shares two characteristic zinc finger motifs. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein.
Links
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Statistics
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PSSM-Id: 188779
Aligned: 16 rows
Threshold Bit Score: 86.2185
Created: 7-May-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding site
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. The Zn binding residues of LIM domain are highly conserved.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #                #  #  #  #                       #  # 
XP_002497883  454 CASCGKYIQEDCIqYHEKRWHLHCFYCSSCQQRIqpqd-kgdaTYNKDSnRILCSHCS 510  Zygosaccharomyces rouxii CBS 732
XP_002555895  454 CAACGKYIQEDCIqFKARRWHKGCFSCSICQRHIdlygvadaaFNTKAN-SVLCAQCA 510  Lachancea thermotolerans CBS 6340
XP_001644503  453 CYSCGKYIQEECIqYQDKRWHTDCLVCSACHNSIninnlsdatFNSTKS-LVLCADCS 509  Vanderwaltozyma polyspora DSM 70294
EEU08965      419 CAGCNKYIQEECIqFYEHRWHIACFTCSSCHKNInprs-ltdpTFNKEKkKILCSHCS 475  Saccharomyces cerevisiae JAY291
ACD01428      469 CTLCKKPIEDECAkSGDKRWHITCVNCSRCQKELgrsl-qdarLNLYDS-KIFCNNCE 524  Neurospora crassa
XP_001547942  467 CVKCQKPIEDECVrFEERRCHLTCLQCSNCERDLvqnl-ddirFNDVEQ-RIYCSDCQ 522  Botryotinia fuckeliana B05.10
XP_361932     467 CSLCRKPIEDECAkNEEKRWHIACVACNRCGRELgrsl-hdaqFNPYDQ-KIFCTNCG 522  Magnaporthe grisea 70-15
EEY18627      454 CALCGRSVEDECAqNEDKRWHITCVKCTRCETDLgrkl-edarFNAFDQ-SVYCTNCT 509  Verticillium albo-atrum VaMs.102
XP_445418     427 CVRCQTYIQDECIqFNEYRWHLKCFSCNICSESIkpsd-vtdaTFNKEKmFILCSRCS 483  Candida glabrata CBS 138
XP_002835763  467 CVNCHTTIEEECAkCGDRRWHLNCLTCSGCKREYkgnl-edrlWFPSEQ-RVVCQACG 522  Tuber melanosporum Mel28

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