Conserved Protein Domain Family
LIM2_Lrg1p_like
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cd09392: LIM2_Lrg1p_like 
The second LIM domain of Lrg1p, a LIM and RhoGap domain containing protein
The second LIM domain of Lrg1p, a LIM and RhoGap domain containing protein: The members of this family contain three tandem repeats of LIM domains and a Rho-type GTPase activating protein (RhoGap) domain. Lrg1p is a Rho1 GTPase-activating protein required for efficient cell fusion in yeast. Lrg1p-GAP domain strongly and specifically stimulates the GTPase activity of Rho1p, a regulator of beta (1-3)-glucan synthase in vitro. The LIM domain is 50-60 amino acids in size and shares two characteristic zinc finger motifs. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein.
Links
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Statistics
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PSSM-Id: 188778
Aligned: 14 rows
Threshold Bit Score: 87.0289
Created: 7-May-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding site
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. The Zn binding residues of LIM domain are highly conserved.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #                #  #  #  #                  #  # 
ACD01428      162 CYQCGGALRgsYITALDRKYHVDHFTCSLCPTVFgaqDSYYEHDGHVYCHYHY 214  Neurospora crassa
O43052        180 CASCGMALRgyYITALNKKFHIEHFTCSLCYTVFgpnDSYYEYEGKVYCHYHY 232  fission yeast
XP_001728898  162 CAKCGRALRgsYITALGSKYHVDHFTCSLCSTPFgpeDSYYEHEGQVYCHFHY 214  Malassezia globosa CBS 7966
EEH35098      159 CSKCGGALRdlYISAIGRKYHMNHFTCHSCQKIIgsgDNYYVHRGQAYCKDDY 211  Paracoccidioides brasiliensis Pb01
EEU38303      388 CFKCDQALResYISALDRKYHIDHFLCDDCGVIFkasDSYYEYKNKLVCVWDY 440  Nectria haematococca mpVI 77-13-4
EFI98264       57 CAKCGMALRgsYITACNKKFHVEHFTCSLCPTLFgpqDSYYEHDNDVYCHFHY 109  Schizophyllum commune H4-8
XP_571603     310 CAKCDQALRasYITACGAKYHVEHFTCSECDVLFgpnDSYYEHDGRVYCHYHY 362  Cryptococcus neoformans var. neoformans ...
XP_002171830  119 CAKCGSAIRdsYITAAGQKYHVDHFTCQMCPTVLgprDCYYLHEDQTYCSFHY 171  Schizosaccharomyces japonicus yFS275
EFP77842       60 CAKCGGALRgsYITALDMKFHVEHFTCSVCPTVFgpqDSYYEHSGQVYCHFHY 112  Puccinia graminis f. sp. tritici CRL 75-...
EFR02231      170 CFECGGALRgsYITALDHKYHIEHFTCSVCPTVFgaqDSYYEHEGKVYCHYHY 222  Arthroderma gypseum CBS 118893

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