CDD Conserved Protein Domain Family: LIM1_Lhx2

cd09369: LIM1_Lhx2_Lhx9

The first LIM domain of Lhx2 and Lhx9 family

The first LIM domain of Lhx2 and Lhx9 family: Lhx2 and Lhx9 are highly homologous LHX regulatory proteins. They belong to the LHX protein family, which features two tandem N-terminal LIM domains and a C-terminal DNA binding homeodomain. Members of LHX family are found in the nucleus and act as transcription factors or cofactors. LHX proteins are critical for the development of specialized cells in multiple tissue types, including the nervous system, skeletal muscle, the heart, the kidneys, and endocrine organs, such as the pituitary gland and the pancreas. Although Lhx2 and Lhx9 are highly homologous, they seems to play regulatory roles in different organs. In animals, Lhx2 plays important roles in eye, cerebral cortex, limb, the olfactory organs, and erythrocyte development. Lhx2 gene knockout mice exhibit impaired patterning of the cortical hem and the telencephalon of the developing brain, and a lack of development in olfactory structures. Lhx9 is expressed in several regions of the developing mouse brain , the spinal cord, the pancreas, in limb mesenchyme, and in the urogenital region. Lhx9 plays critical roles in gonad development. Homozygous mice lacking functional Lhx9 alleles exhibit numerous urogenital defects, such as gonadal agenesis, infertility, and undetectable levels of testosterone and estradiol coupled with high FSH levels. Lhx9 null mice are phenotypically female, even those that are genotypically male. As in other LIM domains, this domain family is 50-60 amino acids in size and shares two characteristic zinc finger motifs. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein.

Feature 1 # # # # # # # # Q68EY3 73 CAGCGGKISDRYYLLAVDKQWHLRCLKCCECKLTLESELTCFAKDGSIYCKEDY 126 African clawed frog NP_001139341 130 CAGCGMRITDRFYLQAVDRRWHASCLQCCQCRNTLDGEITCFSRDGNIYCKKDY 183 red flour beetle XP_002592484 15 CGGCGEKIQDRFFLHAVDRQWHSACLKCCECDVRLDCELTCFSKDGRIYCREDY 68 Florida lancelet BAJ09782 7 CGGCGFKITDRYYLVAVERAWHSECLRCGECRRPLDTALSCFSRQSRIYCRDDY 60 Daphnia magna XP_001946004 14 CDGCGLKILDRYYLFAVDKRWHASCLQCSQCTRTLASEIKCFYRDGNIYCKADY 67 pea aphid XP_001649304 139 CAGCDMPIQDRFYLSAVERKWHATCLQCCICRQTLEGANSCFSRDGNIYCKTDY 192 yellow fever mosquito NP_001163058 147 CSGCGRQIQDRFYLSAVEKRWHASCLQCYACRQPLERESSCYSRDGNIYCKNDY 200 fruit fly XP_392622 218 CAGCGLRISDRFYLQAVDRRWHAACLQCSHCRQGLDGEVTCFSRDGNIYCKKDY 271 honey bee XP_002432397 285 CAGCGRKISDRFYLSAVDRKWHATCLQCCQCRIALDGEITCFTRHGNIYCKKDY 338 human body louse XP_002401118 38 CAACGAPIADRFYLLAVERQWHTHCLRCCHCKQQLDSELTCFARDGNIYCKEDY 91 black-legged tick

Conserved Protein Domain FamilyLIM1_Lhx2_Lhx9

Conserved Protein Domain Family
LIM1_Lhx2_Lhx9