2CO8,2D8Y


Conserved Protein Domain Family
LIM_Mical_like
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cd09358: LIM_Mical_like 
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The LIM domain of Mical (molecule interacting with CasL) like family
The LIM domain of Mical (molecule interacting with CasL) like family: Known members of this family includes LIM domain containing proteins; Mical (molecule interacting with CasL), pollen specific protein SF3, Eplin, xin actin-binding repeat-containing protein 2 (XIRP2) and Ltd-1. The members of this family function mainly at the cytoskeleton and focal adhesions. They interact with transcription factors or other signaling molecules to play roles in muscle development, neuronal differentiation, cell growth and mobility. Eplin has also found to be tumor suppressor. As in other LIM domains, this domain family is 50-60 amino acids in size and shares two characteristic zinc finger motifs.. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein.
Links
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Statistics
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PSSM-Id: 188744
Aligned: 49 rows
Threshold Bit Score: 66.1381
Created: 21-Jul-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:2D8Y_A: Human Eplin protein LIM domain binds Zn
  • Comment:The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. The Zn binding residues of LIM domain are highly conserved.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #                 #  #  #  #                                  #  # 
2CO8_A         18 CALCGEHLYvlerlcVNGHFFHRSCFRCHTCEATLwp-------ggYEQHPGd--------gHFYCLQHL 72   human
XP_650090       4 CPVCGKKAYqmesivIEGITMHKNCFRCSVCKKTLng-------snFAKNHG----------IYYCKVHF 56   Entamoeba histolytica H...
2D8Y_A         18 CVECQKTVYpmerllANQQVFHISCFRCSYCNNKLsl-------gtYASLHG----------RIYCKPHF 70   human
BAH72453       56 CESCEKKVYplekveIEGRPFHRSCFRCTQCQCVLrm-------dtFTWNNN----------RLYCLPHF 108  pea aphid
XP_001515709  595 CSLCGGHLYileqlrADGRFFHSNCFRCHFCEAKLrp-------gnYRGHPGe--------gHFYCSLHL 649  platypus
EFN72461     1383 CESCQKKVYplekveTNNKIFHKQCFRCLQCNCILrm-------dsFTLNNG----------KLYCIPHF 1435 Camponotus floridanus
NP_001023516  508 CSLCTKNVYraeqfqCFGLLYHVNCFRCIDCKQALrv--------eKAHRCQqs-------gDLYCRVHF 562  nematode
XP_002572994  876 CYVCQKRLYqlervrVSGYYLHKDCLRCSTCDILLnkdsvkcvsskKANEKA----------LFYCHLHV 935  Schistosoma mansoni
XP_002415485  156 CSICSKRLYpmermeASGLTMHKNCFRCSQCRCIL-----------RLENYAds------cgTLYCGAHY 208  black-legged tick
XP_001900176  949 CQLCLKVVYlaermqVEGMFIHKKCFRCAFCEQPL-----------RLGNCAqdrnlrsfnpRFFCMQHI 1007 agent of lymphatic fila...

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