3M71,3M7L,3M76,3M75,3M73,3M74,3M72,3M78,3M77


Conserved Protein Domain Family
TDT_TehA
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cd09324: TDT_TehA 
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Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein
This subfamily includes Tellurite resistance protein TehA that belongs to the C4-dicarboxylate transporter/malic acid transport (TDT) protein family and is a homolog of plant Slow Anion Channel-Associated 1 (SLAC1). The tehA gene encodes an integral membrane protein that has been shown to have efflux activity of quaternary ammonium compounds. TehA protein of Escherichia coli functions as a tellurite-resistance uptake permease.
Links
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Statistics
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PSSM-Id: 187764
Aligned: 27 rows
Threshold Bit Score: 318.055
Created: 29-Oct-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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gating
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:gating phenylalanine in ion channel
Evidence:
  • Comment:Mutational and structural studies in Haemophilus influenzae TehA (HiTehA) show that this residue plays a crucial role in gating of the anion channel
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
3M71_A        10 PTGYFGIPLGLAALSLAWFHLenlfpAARMVSDVLGIVASAVWILFILMYAYKLryyFEEVRAEYHsPVRFSFIALIPIT 89  Haemophilus inf...
Q89JW1        29 PAAFFGIVLGLAGLGNAWRAAhqvwhLPAIVGEILLALASIVWALLLVLFILRWilaRAESLSEAHhPVQCCFIGLAGVS 108 Bradyrhizobium ...
YP_001354506  14 PPSFFGIVLGLAGLAGTWRAAhavwdMPSIIGEAIYALAAVAWLVIVLLYLLKWiiaPTIAKEEAEhAVQCCFIGLAGVS 93  Janthinobacteri...
Q3BT64        12 PASYFGVVLGVAGLGQAWRSAvqlwhLPSAIGEALLAMAGLIWAALIIGYVWQSirnFEAAKAEFLhPVQGGTPALIAVS 91  Xanthomonas cam...
Q13KC4         9 PVAFFGIAVGALAFANLWRVAirlwhLPAAIGTLTTAAALVVWLVILAAYGQKWlthAAEARTEMQhPVQSSFAALGPVS 88  Burkholderia xe...
P25396        10 PAGYFGIVLGTIGMGFAWRYAsqvwqVSHWLGDGLVILAMIIWGLLTSAFIARLirfPHSVLAEVRhPVLSSFVSLFPAT 89  Escherichia col...
ZP_07358391   16 PVAYFGMVLGIIGMGSAWRFAaqhwaLPAVVGESLMALGVAVWLALTCVFIYKWlfrRAAALAEVRdAIQCCFISLFPGT 95  Desulfovibrio s...
ZP_06906158   23 PTSYFSVALGTSALGLSWRYGatanlVPSWVGESILALASATWLALIAAFAVKLitrRDALQSELRdLVMCCFLALVPVT 102 Rothia dentocar...
YP_001524307  12 PASFFGIVLGLIGWGNCWRAAheiwgLPSAVGEAMMFAGSLVWAVLIVLFAGKWlsaRAEALAEARhAVNCCFIGLVGVA 91  Azorhizobium ca...
YP_003693487   2 RPVFFGSVLGIGGLANGWRAVnrlwgITPVIGEAFAVAAFGLWLLWAVLYAGKWllhPAEARRELDhPVQGLAAALAPVA 81  Starkeya novell...

Feature 1                                                                                        
3M71_A        90 TMLVGDILYrwnpLIAEVLIWIGTIGQLLFSTLRVSELWQGGvfeqksTHPSFYLPAVAANFTSASSLALLGYHDLGYLF 169 Haemophilus inf...
Q89JW1       109 TMLIAIAAEpyshLAAEILFGLGAAFTLGFALWRTGLLWRGNrdh-taTTPVLYLPTVAGGFVTAAVSSVLGYPDWGQLA 187 Bradyrhizobium ...
YP_001354506  94 TLLIAQGALpysrLLAITLFFLGAGFTIFFGLWRTGLLWRGDrdp-asTTPVLYLPLVAGGFVTGIVASSLGWQEWGELA 172 Janthinobacteri...
Q3BT64        92 TLLIAIAVIpysmALAWLLTIGGIAWNIGFALWHTGTLWQGGrns-edMLPTLYLPTVAGNLTTAAALGALGSADWGWIF 170 Xanthomonas cam...
Q13KC4        89 TLLAAQLLQpyahALALALFGVAIVAQLALGVYLHGRLWQGGrqp-elVTPAIYLPTVAPSFVAGTAAAAFGFHQLGGLF 167 Burkholderia xe...
P25396        90 TMLVAIGFVpwfrPLAVCLFSFGVVVQLAYAAWQTAGLWRGShpe-eaTTPGLYLPTVANNFISAMACGALGYTDAGLVF 168 Escherichia col...
ZP_07358391   96 TMLVGVAVApyarPLAFWLIVLGTVGQLAFAAYRSAGLWRGQhtp-eaTTPGVYLPTVASNLISAIALGSLGYGHWGFLF 174 Desulfovibrio s...
ZP_06906158  103 TIEVGISAYpyaaLLGYALILIGVLGQLAFSMYRTAGLWRGThtv-aaTTPVIYLPTVAANFASASGLGALGHRDWAMLF 181 Rothia dentocar...
YP_001524307  92 TMLVAIAAHpyaaSPALALFLLGAAFTLAFGLWRTGVLWQGGrdp-aaTTPVLYLPTVAGSYVTAIGCAAFGFPDWGRFA 170 Azorhizobium ca...
YP_003693487  82 TLIASLCIGphvtVLGWALFIGGAGGVLFYAAWSVGGLWQGGrea-paITPVLYLPTVGGGFVSALACATFGQPTLGWMF 160 Starkeya novell...

Feature 1                                                                                        
3M71_A       170 FGAGMIAWIIFEPVLLQHLRiss-lepQFRATMGIVLAPAFVCVSAYLSINhGEVDTLAKILWGYGFLQLFFLLRLFPWI 248 Haemophilus inf...
Q89JW1       188 FGIALFSWLAIESVLLHRLYtvatlpvALRPTLGIQLAPPAVGAVAYLAINgGVPDMVAHVLVGYGLMMALLLLRLLPWI 267 Bradyrhizobium ...
YP_001354506 173 FGAGFFGWLAIESVLLHRLYvapplslPLRPTLGIQLAPPAVGAVCYMAVSgGHPDLLVHMLIGYALLQALILVRMSRWI 252 Janthinobacteri...
Q3BT64       171 LGAGFFSWLALESLVIHRLWhstsipaPQRPLIGIQFAPPVVCAMAWLALSpGSTDHWLLMLWGYGLFQLLLGLRLGLWL 250 Xanthomonas cam...
Q13KC4       168 FGAGLLSWLAIESLILHRAAvheplpdALRPLLGVQLAPPVVGGVTYLSLSsGTPDLFALALLGYGLYQALLLLRLLPWI 247 Burkholderia xe...
P25396       169 LGAGVFSWLSLEPVILQRLRssgelptALRTSLGIQLAPALVACSAWLSVNgGEGDTLAKMLFGYGLLQLLFMLRLMPWY 248 Escherichia col...
ZP_07358391  175 LGAGIFSWLSLEPVILARLRtmgelpkPVRPTIGIQLAPPLVACTAYLSVNgGVADIFAQVLFGYGLLQLIFLARLLVWT 254 Desulfovibrio s...
ZP_06906158  182 FGMGLLSWFSVEAAILGRLRtepaldpAVRGIIGVQLAPPFVGGNAYLAANgGHVDWVFLVLTGYGVLQLLFLLRLVPWV 261 Rothia dentocar...
YP_001524307 171 LGVGVLSWFAIESVLLHRLYtspempaPLRPVLGIQLAPPTVGAAAYLSVTsGPPDVIIYGLIGYGLIQLLLLARLLPWI 250 Azorhizobium ca...
YP_003693487 161 FGFGMFSWLSMESVFLTRLFqhg-lpaEMRATLGIEFAPPVVACVAYLSLTpGTADHFALGLFGYGCFLALVLLRLVPWL 239 Starkeya novell...

Feature 1                     #                                                
3M71_A       249 VEkGLNIGLWAFSFGLASMANSATAFYHgnvLQGVSIFAFVFSNVMIGLLVLMTIYKLTKGQ 310 Haemophilus influenzae
Q89JW1       268 MEqPFSVSYWGFTFGATALAIAPIRMAGhgdTGAIALLAPWLFGAANIVVGLIALGTLRLIL 329 Bradyrhizobium japonicum
YP_001354506 253 GEqAFGASYWAFTFGATALASAIIRLAAgsqQGVFTTLAPAMFLIANIIVVTIAAGTIRLLI 314 Janthinobacterium sp. Marseille
Q3BT64       251 GVqPFIPAYWAYTFGVAAATVSGLKLAQa-gIHSAQVLAVPVFVGANVFIGYLVIRTVHLLI 311 Xanthomonas campestris pv. vesica...
Q13KC4       248 RQrAFVPGYWAFSFGVAALPTMVLRMVErgaTGPLEWAAPVLFVAANLIIAILVVKTLGLLV 309 Burkholderia xenovorans LB400
P25396       249 LSqPFNASFWSFSFGVSALATTGLHLGSgsdNGFFHTLAVPLFIFTNFIIAILLIRTFALLM 310 Escherichia coli H736
ZP_07358391  255 FEqPFSPSFWSFSFGISALSASALRFLAhdpTSPISLLSWPIFIFSNLVIGLLIIGTLIRIV 316 Desulfovibrio sp. 3_1_syn3
ZP_06906158  262 LKaGYTMSLWGFSFGLGAMAGTGIHLVA---VSQLVQLGWALWILGTALIAVLWLGMLMLAI 320 Rothia dentocariosa ATCC 17931
YP_001524307 251 FAgGVTASMWGFSFGLTALATAMVRLVGrgdVGPVATLAPAVFALVSAALTTMVLRTIWLLL 312 Azorhizobium caulinodans ORS 571
YP_003693487 240 RRqPFGPGAWAYTFGVSALPLAALKLVEqgaGTPIELLALPSFAAANAIIGWIAVRSLVRVG 301 Starkeya novella DSM 506

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