3M71,3M7L,3M76,3M75,3M73,3M74,3M72,3M78,3M77


Conserved Protein Domain Family
TDT_TehA_like
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cd09322: TDT_TehA_like 
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The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA proteins
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane a-helical spanners (TMSs).
Links
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Statistics
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PSSM-Id: 187762
Aligned: 125 rows
Threshold Bit Score: 91.0644
Created: 22-Nov-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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gating
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:gating phenylalanine in ion channel
Evidence:
  • Comment:Mutational and structural studies in Haemophilus influenzae TehA (HiTehA) show that this residue plays a crucial role in gating of the anion channel
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
3M71_A        13 YFGIPLGLAALSLAWFHLenlfpAARMVSDVLGIVASAVWILFILMYAYKlryyfEEVRAEYHsPVRFSFIALIPITTML 92  Haemophilus inf...
YP_280168     70 NPPLVMSGLALGTLSFGNll-atYVSIFSYLGILAALFIYGILLVGMVRNl----NDTKMQLRqPLIASVFPTFFMTGML 144 Streptococcus p...
Q8E4V6         6 KPPLVMAGLVLGLLALGNll-egYGTYFRYCLGLVALVFWIFLIKGILKNk----KESRKELSnPLIASVFTTFFMAGMI 80  Streptococcus a...
Q8DRT5         6 NPPLVMSGLTLGLFALGNll-klYHPSLRHLLSIIALLLYLFLILSILKNl----SQALEQIKhPLIASIFPTFFMSGML 80  Streptococcus m...
Q6GHR3         5 KAPLVTSGLVLGLLGLGNll-kdLSLTLNAICGIFAFLIWIHLLCTMLKYf----NNVKEQLNsPLVSSVFTTFFMSGFL 79  Staphylococcus ...
YP_001035852   5 RPPILLSGLILGLFGLANll-lnYHSIFFHFLNGLALILWLYLTLALVLSf----SDYRQDLQkAPFLSSFATYPMASML 79  Streptococcus s...
Q97SG1         3 KLPLVFSGCLLGLAGAGNli-ldTLPVLSHLFSLIGLVLWIYFLILHLFNw----KETKQELTkPPLLSGMATFPMAGMI 77  Streptococcus p...
YP_002562451   6 KPPLVLSGLILGLVALANll-snYNNHVKLPLMAIALCLYGLLIYGILRNk----EIAMKQLKsPLVASVFPTFFMVTML 80  Streptococcus u...
YP_003180602   7 KVPIPTAGVALGLAALGNll-qpYTEIVHIVCGILSLVLIAMLGAKIALFp----DMIRDDLHnSIMASVSATLFMTLMQ 81  Eggerthella len...
ZP_04776090    6 NLPTPIAGLALGSAALGNll-qpYSSSLQLLFNLLSLIIIVLLTIKFVLGf----DKLKKEMEnPVVATVMATYPMSIML 80  Gemella haemoly...

Feature 1                                                                                        
3M71_A        93 VGDILYrw------npLIAEVLIWIGTIGQLLFSTLRVSELWQGGvfeqksTHPSFYLPAVAANFTSASSLALLgyhDLG 166 Haemophilus inf...
YP_280168    145 LSSLFLkvt----ggcWLGFLTWWLFFLGNLVLIAYYQYRFVFSFsw--dnVFPSWSVLFVGIAMAALTAPASRq-fLLG 217 Streptococcus p...
Q8E4V6        81 LSTYILlfrslgiwvaVLSKGVWWLSFIALIIHMAIFSWKYLRHFsm--anLFPSWSVLYVGIGVASLTAPISGq-fTIG 157 Streptococcus a...
Q8DRT5        81 LAGYIQtfpfledwvtLISLTIWWLAFLGNAGLIAYFTIKFVIPFhw--ehVFPSWSVLYVGIAVATLTAPISGq-yILG 157 Streptococcus m...
Q6GHR3        80 GTTYLNtffsnitfinNLITPIWILCLVGIMMHMIIFSIKYLKDFsl--enVYPSWTVLFIGIAIAGLTAPVSGy-fFIG 156 Staphylococcus ...
YP_001035852  80 LAAYLNklg-----llWMSQLLWYLALLLHIFLIAIFTWKYVLKTeg--lsLTPSWTVLYVGLAMASLTQGVVHq-pLLG 151 Streptococcus s...
Q97SG1        78 LSTYVFrvfs---ylpLVAQGIWWFSFLLDLTLIAGFTIKFACPGrr--vhATPSWTVLYVGIAVAALTYPLVGi-iEIA 151 Streptococcus p...
YP_002562451  81 LASQLVhyh-----lkGPGQVLWWFGCIGDLVLMTYYILRFVLAFsw--dnVFPSWTVLFVGIAMTALTAPTSGa-yFLG 152 Streptococcus u...
YP_003180602  82 LAGYLApf------ayIPAFALWSAAVVAHLALMGWFTARFISHFkl--heVFPTYFICYVGIVVASVTSPTFGm-eAVG 152 Eggerthella len...
ZP_04776090   81 LASFSKky------igLLSMPVWIIGIFLDFCVVCYAIYNFIIKErhi-skIYPTWFITFVGPAVVTVTAINYNl-eMLG 152 Gemella haemoly...

Feature 1                                                                                        
3M71_A       167 YLFFGAGMIAWIIFEPVLLQHLRiss-lepQFRATMGIVLAPAFVCVSAYLSInhge---vdtLAKILWGYGFLQLFFLL 242 Haemophilus inf...
YP_280168    218 QVIFWVCLLLTAVILPFMAKKTYgig-lgqAVMPNISTFCAPLSLLSASYLATfprp---qvgMVIFLLISSQLLYAFVV 293 Streptococcus p...
Q8E4V6       158 KIVFWYGFIATLVLLPFLFIKAYkig-lpsAVKPNITTICAPMSLITAGYVNSfvsp---nrgLLLLLIVMAQFLYFFIL 233 Streptococcus a...
Q8DRT5       158 QIIFWTCLLLTLLILPLMTIKAYcig-lpeTAKPNICTFCAPLSLLLAGYLKTfppeqspntnFVWLLLLASQLLYFFVV 236 Streptococcus m...
Q6GHR3       157 QLTVIYGFVATCIVLPIVFKRLKafp-lqtSIKPNTSTICAPFSLVAAAYVIAfpka---nafIVIILLLLAQIFYFYII 232 Staphylococcus ...
YP_001035852 152 YLAWFFALLLSLILYPLFYRARRsqr-lpdALKPQWAIYCAPFSLLLGSYIRLagsd--aegwFVALLLLLSQAFYLLVL 228 Streptococcus s...
Q97SG1       152 YATLSFGFLLTFYLYPLIYSDLKkhp-lplALLGQEGIYCAPFSLLLASLVRVggts--lptwVLIVMILASQSFFFFVL 228 Streptococcus p...
YP_002562451 153 QCVFWLCLSATFLIFPVIYKKTYhig-lpeANLPNISTFCAPLSLLLAGYLVTfatp---nplLVILLMVISQAAYFFVL 228 Streptococcus u...
YP_003180602 153 HLLFWFGFACYVVLLGLVTYRYMkhe-ipeSARPLFCIYTAPMSLSLVGYLATapqp---nlvFVLAMLVLAQVLFAVVL 228 Eggerthella len...
ZP_04776090  153 LIYFYFSYINYLLLLPFVLYRVYkykhykdGDYPTITVFSAPGGLLLASYMIGvtqk---sniILAILIPLTILLFIFVL 229 Gemella haemoly...

Feature 1                           #                                            
3M71_A       243 RLFPWIVekGLNIGLWAFSFGLASMANSATAFYHgnv----lqGVSIFAFVFSNVMIGLLVLMT 302 Haemophilus influenzae
YP_280168    294 VQLPRLLnrPFNPGFSAFTFPFVISATSLKMTLSflg----wqGLGWQVLLLGEVLLATALVTY 353 Streptococcus pyogenes MGAS6180
Q8E4V6       234 FQVPKLLigDFTPGFSAFTFPLVISATSLKLSIQhl-----slPVDIQGLVHFEIGTTTLIVMI 292 Streptococcus agalactiae serogr...
Q8DRT5       237 LQLPVLLkrEFNPGFSAFTFPFAISATALRSAGSylh----lqLPLFQLLVKLEELLASILVLF 296 Streptococcus mutans
Q6GHR3       233 IQLPKLLkePFSPVFSAFTFPLVISATALKNSLPvl-----mfPVIWKGLLFIEVLLATVIVLR 291 Staphylococcus aureus subsp. au...
YP_001035852 229 CLLPRIFrlGPQLSWSALTFPLVNTAFALKLGLDyl------gWTWLVWLSHAEALLAVVIVLY 286 Streptococcus sanguinis SK36
Q97SG1       229 TRLPNILkqGFQPAFSALTFPTIITATSLKMAQGil------kLPFLDYLVLAETIICLTILFF 286 Streptococcus pneumoniae
YP_002562451 229 VQLPKLLnrPFNPGFSAFTFPFVISATSLRMAVHyc-----rlEKMLGLLVTIEVLIATGLVGY 287 Streptococcus uberis 0140J
YP_003180602 229 SRLPVLLrlRFYPSYAAMTFPFVITATALGKALAffqanglavPEVLNVLFAAEAAVSVVMVGY 292 Eggerthella lenta DSM 2243
ZP_04776090  230 FQLPYLLkrKFYPSFSAFTFPLVICAISFQKTGVyyq---laeFSILNILIHLSELLAIIIVIY 290 Gemella haemolysans ATCC 10379

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