Conserved Protein Domain Family
TDT_like_2
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cd09320: TDT_like_2 
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane alpha-helical spanners (TMSs).
Links
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Statistics
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PSSM-Id: 187760
Aligned: 24 rows
Threshold Bit Score: 226.051
Created: 29-Oct-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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gating
Feature 1:gating phenylalanine in ion channel
Evidence:
  • Comment:Mutational and structural studies in Haemophilus influenzae TehA (HiTehA) show that this residue plays a crucial role in gating of the anion channel
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
A0AVZ8         45 PNWFASIMGTGIVATAAATLplq--------fpgLRTGATVVWALASMLLILLTTATVVHwir-------hreTAQSHHs 109 Arthrobacter s...
YP_887127      60 PNWFASVMGTGIVATAAVTLpvq--------asgLRAFATAVWILAAALLVALTAAFTTHw-----------mRHRHHAv 120 Mycobacterium ...
BGI:SBI_00659  40 PNWYASVMGTGIVANAAVTLpvh--------vtgLRPAATLVWLLAAALLVALTAAWAVHw-----------rRHPTRAr 100 Streptomyces b...
ACY23739       30 PNWFGAVMGTGIVATAATTLpvg--------aavLRPFAIAVWVVAVLMLLVLTIAFAGHw-----------fQHTDHAr 90  Gordonia bronc...
ZP_06826759    30 PNHYAAVMGTAMLATAGSGLpqh--------vagLRALCAALWGVAALALLAVLAARGAHwa---------rhRDQARAh 92  Streptomyces s...
YP_001500979   28 PNWFASVMGTGIIANAAVGLplv--------gkdLSSIGFVIWLLAALMLLAMLLIKIIQt-----------iLKPHIIk 88  Shewanella pea...
Q828E8         28 PNWYASVMGTAIVATAGAGLpsgsaaglpgdlpgLRTACTAFWALSLIMLVTLLGARALHwi---------hhRDQARAh 98  Streptomyces a...
YP_002765434   17 PNWFAAAMGTGIVSVAAASLepe--------iegLKLVSEIFWVLAVLVLCALIGAFATHws---------qhRCQALAy 79  Rhodococcus er...
Q0S379         10 PNWFAAVMGTSIVAVVAAAFpag--------gpvARTAAEIFWLIAATLLVVLTTALVRHwi---------rrRDDALAd 72  Rhodococcus jo...
ADB53268        5 PNWFTAAMGTGIVANAAVLLprd--------aawLRALALAAWLAAALLLLRLAAVAVEQwrrgrrvrdcagrRVRGGAa 76  Conexibacter w...

Feature 1                                                                                         
A0AVZ8        110 ------hPVMAHFYGAPPMALLTVGAGTLllgkdvlgeqlalGIDTVLWVAGTVLGLASAVAVPYLQFTRHqvtqdsafG 183 Arthrobacter s...
YP_887127     121 gy--anhPVMAQFYGAPAMALLTVGAGSLllgpavigesaavRLGVALWVAGTGLGLAVAVVIPYRMITRCgrev-aavP 197 Mycobacterium ...
BGI:SBI_00659 101 ah--adhPVTAHFWGAPAMALMTVGAGTLtlgrhwiglptalAVDTVLWLSGTVLGLVTSVWIPYRAMTRHsvapdgafG 178 Streptomyces b...
ACY23739       91 ay--arhPVMGHFYGAPAMALLTVGAATLlvggdvigeypavWTDGLLWCAGTTIGVATSVWLPYSMMTRPagdrgvamP 168 Gordonia bronc...
ZP_06826759    93 l----rsPAEAPFYGCLAMAFLALSAATQrvgadvlghgaatGLAEVLLAVGAVLAVAVAAGIPVLMIVHArarfadvsP 168 Streptomyces s...
YP_001500979   89 rq--fndPVMAQFFGAPPMAMLTVAGGTIlfgpeimasetsiTIAWTLWFIGTLGGIATAVIITFRLFTHYkirsdaafG 166 Shewanella pea...
Q828E8         99 lldpttgPTTAPFYGCLAMALLAVGGATLtvgrdwlgttaavVLDAVLFTAGTAVGLAAAVAVPYLMVTRHriepgratP 178 Streptomyces a...
YP_002765434   80 l----hsPAMFPFYGAVAMALLTVGSATGitgpdflghdvaiTVSLTLWILGTALGLVTYVVMMIRLVRDAgma--tamP 153 Rhodococcus er...
Q0S379         73 a----rsHTMFPFYGAVSMAVLTVGAGTGsagral-lggvavTASATLWTIGTVIGLVTYVVMARRLTRPHqvt---pvP 144 Rhodococcus jo...
ADB53268       77 dgs-agdLAMAPFWGAPPMAAMTVGAGALlvggdaigqdaalAVASALWALGTLGGLAASVTVPLRMLRHPerrldtvfA 155 Conexibacter w...

Feature 1                                                                                         
A0AVZ8        184 GWLMPVVPPMVSASTGALLLpyvpagqarlsllMGCYAMFGLSLLASIIITTLIWNRLAghkig-----aaaaVPTLWIV 258 Arthrobacter s...
YP_887127     198 AWMMPVVPPMVSASTGALLLghlgpgqagetllMACYAMFGLSLLVGFVTVTMVYSRLMhgglp-----evqaIPTVWIV 272 Mycobacterium ...
BGI:SBI_00659 179 GWLMPVVPPMVSAANGALLVpyaaagqlrltlvLACYAMFGISVFAALIITVQIWSRLVhhtsq-----paalVPTVWIV 253 Streptomyces b...
ACY23739      169 CWLMSVVPPMVSATTGALLIghlptgqvrltmlCACYGLFGLGLILGMITMTLVYARAVhdgpp-----agaaAPTFWIT 243 Gordonia bronc...
ZP_06826759   169 VWLLPLVAPMVAASVGPGLAgelpagqaretfvYGCLALFGTSLLAVLVVLPLVGARLLtgggw-----ptrlAPSLFLV 243 Streptomyces s...
YP_001500979  167 GWLMPVVPPMVSAAIGAMLIphaptiamqqtmlYACYAMFGVSLMSALIIITMIWSRLVhsgts-----ggarVPTLWII 241 Shewanella pea...
Q828E8        179 VWLLPLVAPMVSAALGPLLVphlpagqpretllLACVAMFGLSLLGTLMMLPMIFARLIttgpl-----plvlTPTLLLV 253 Streptomyces a...
YP_002765434  154 FWLMPVVPPMVSATTGAAVSihmpegapriavlIFCYILFALALTAAIGILIAVARQFArnrsagidvipfnaIPSLWIP 233 Rhodococcus er...
Q0S379        145 SWLMPVVPPMVSAATGAALVkhlpegapqiamlALCYTLFALALSAALTVAVVVGRHLLsnglp-----dtplVPTLWIP 219 Rhodococcus jo...
ADB53268      156 TWLLPVVPPMVSATTGAALIahlpagqprllllLGCWAMLGASLLAVAATIALVWRRLAahgcg-----parmVPTLFIV 230 Conexibacter w...

Feature 1                                                                                      #  
A0AVZ8        259 LGPLGQSITAANLLggnahlavsgt---laqamealgvlYGVPVLGFALMWAALATAITIRTArrglPFSLTWWSFTFPI 335 Arthrobacter s...
YP_887127     273 LGVIGQSITATNLLaahassvvtdts--vvsalhafgivYGVVMGGFGAFVFCVAAALTVHAArrglSFTLTWWSFTFPV 350 Mycobacterium ...
BGI:SBI_00659 254 LGPLGQSVTAANALgsvaplalprp---yatgaevfgllYGLPAWGFAMMWLALAAALTARTVraglPFSLTWWSFTFPV 330 Streptomyces b...
ACY23739      244 LGLIGQSITAANLLggaaagvfdgdqagialglrvfgigYGMVMAGFGTAMFALAVAVTVRAVrrrmPFALTWWSFTFPV 323 Gordonia bronc...
ZP_06826759   244 LGPLGQSTTATGAIadaargvlpdg---targlrvfsvvYGVPVMGFALLWLLIAAALVARALarglRPSSTWWAFTFPV 320 Streptomyces s...
YP_001500979  242 LGPLGQSITAAGTLgavavlvvdep---iatsmntmailYGVPIWGFAFFWSILASLLTLSALrrkmPFALTWWAFTFPV 318 Shewanella pea...
Q828E8        254 LGPLGQSTTAVGKFadfapgvvpap---ydqgfgvlavlYGVPVMGFALLWLGLAVALVVRARrrgmGFALTWWAFTFPV 330 Streptomyces a...
YP_002765434  234 LGVIGQSIAASNLLaaasrhalste---hadtlhefgiaYGTVVGIIGVIAFVTVTTVTIHALrrglDFSLGWWSFTFPI 310 Rhodococcus er...
Q0S379        220 LGVIGQSVAAINLLggvsghaw----------lhsvgvvYGTTVGALGVLALVTLVTVTVRAFrrglGFTPGWWSFTFPV 289 Rhodococcus jo...
ADB53268      231 LGPLGQSITAACLLaaaapaatgaa---wagsagalalvYGLPVLGFALAWLAVAVTITWRTArrglPFAPTWWSFIFPI 307 Conexibacter w...

Feature 1                                                  
A0AVZ8        336 GTCVTGLTGLaahthlaVFDAMAVAGYTLLVAAWIIVAART 376 Arthrobacter sp. FB24
YP_887127     351 GTCVTGASALgaatgavVFSGLAVLLYVALLVAWVTVAMHT 391 Mycobacterium smegmatis str. MC2 155
BGI:SBI_00659 331 GTCVTGTSALamrtgsaALQGASAVLYVFLVVSWCTVAVRT 371 Streptomyces bingchenggensis BCW-1
ACY23739      324 GTCVTGLAALgkgldarGVEAASVVLFVALVAAWGLVAAMT 364 Gordonia bronchialis DSM 43247
ZP_06826759   321 GTCVTGPTQLaahtglaAYRWLAAGIYVLLLLAWCAAAFGA 361 Streptomyces sp. SPB74
YP_001500979  319 GTCVTGTSQLaihtglpAFEWAAIMLFTGLICAWIIAAIGT 359 Shewanella pealeana ATCC 700345
Q828E8        331 GTCVTGAEALarhtglaAFDGLAVALYAGLVAAWAVTAART 371 Streptomyces avermitilis
YP_002765434  311 GACAVGANAFgvatgstLILGIALALLTVLIPIWATVAVRT 351 Rhodococcus erythropolis PR4
Q0S379        290 GTCALGANSLgvaldsvVIVGAGMTLWCALVLIWSTVAVRT 330 Rhodococcus jostii RHA1
ADB53268      308 GTCVTGASELavrtgaaPLDWLAIALFALLLTAWLVVTGAT 348 Conexibacter woesei DSM 14684

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