Conserved Protein Domain Family
TDT_Mae1_like
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cd09317: TDT_Mae1_like 
C4-dicarboxylate transporter/malic acid transport protein family includes Mae1
This family contains eukaryotic homologs of C4-dicarboxylate transporter/malic acid transport proteins which are part of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family. This includes the MAE1 gene in Schizosaccharomyces pombe gene that encodes malate permease, Mae1, which functions by proton symport and transports C4-dicarboxylates (malate, fumarate, succinate, oxaloacetate, etc.), but not K-ketoglutarate.
Links
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Statistics
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PSSM-Id: 187757
Aligned: 23 rows
Threshold Bit Score: 245.625
Created: 29-Oct-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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gating
Feature 1:gating phenylalanine in ion channel
Evidence:
  • Comment:Mutational and structural studies in Haemophilus influenzae TehA (HiTehA) show that this residue plays a crucial role in gating of the anion channel
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
P50537        38 WFACTMATGGVGLIIGSFPfrf-ygLNTIGKIVYILQIFLFSLFGSCMLFRfik---------ypsTIKDSWNH------ 101 fission yeast
XP_001262348  75 FFTLSMSTGGIANALYNVPykf-rgLEMIGIIVFLFNIALYITIWCILLLRfyl---------hpyTFKLSLTH------ 138 Neosartorya fis...
XP_001397338  25 WYAISLSWGGIAVLLHQTPnqf-tgLTTIGTIVFIANLVIYTTVTLCLLFEavrpqkvpkpleespNFAARWLHik---- 99  Aspergillus nig...
Q4P299        36 WFTSCMSLGGIANLLMARIfds-diAFGIGAVLFAVNVCYLIALFSLQIVRytm---------tpaSLLYTLSH------ 99  Ustilago maydis
O59815        34 WFASAMGTGGIGMVTSLYHfrf-ygLNTLGKIIFIFQLSILTLYICCITFRfir---------ypgTLSKTWKN------ 97  fission yeast
Q8X021        33 WFTMTMATGGVANVLHSIPyks-qwLTGVGLFFFFLNLVLFTVNCICITLRfvw---------srgSFLHSLND------ 96  Neurospora crassa
Q2USN1        24 WYSISMATGGIAVLLYNTPhqf-tgLETIGKIVYVFNLVLFLSISLCLSFRflt---------kssALKESFQH------ 87  Aspergillus oryzae
XP_385382     36 PFFTAAAPAAHDGKTNQNPrrlavpRPALTQRPSYIAAIAFEDANGNNQSRprlvn------qsstITAHSLNHvmatve 109 Gibberella zeae...
XP_003033680  36 AFPIGMGTGAVYVTLSGLKehs-daLTTVETVFFFLNIILFTLNCTTLLIQaii---------yprQALRLIKD------ 99  Schizophyllum c...
XP_002910709   2 DVASWMGTSAVFLTLSGHEgs--paIDVFENIFFFATIGIFGLNTLTLTIQail---------ypkQALRTLVN------ 64  Coprinopsis cin...

Feature 1                                                                                        
P50537       102 -----------HLEKLFIATCLLSISTFIDMLaiyaypdt--------gewmvwvIRILYYIYVAVSFIYCVMAFftifn 162 fission yeast
XP_001262348 139 -----------PTESLFVPASIVSFGTILINIsqygpeat--------gpwlsyaVGVLFWIDAALAVILSAGIYlllws 199 Neosartorya fis...
XP_001397338 100 ----------kPQDLYFVPVSLLAFATIIFCTsyygtphc--------grwliltLNVFFWVYTGVSLLLSILLGwwipy 161 Aspergillus nig...
Q4P299       100 -----------PIECCFVPTALLACATAIIGLsnvagnns--------gkawevvLRVLFWIYFVASIIVSLVCYtflfs 160 Ustilago maydis
O59815        98 -----------PSEVLFMPTALLAIATSISNLypyafpyt--------gewmvwlIRILYWIFVAVACIFVISLFyslfh 158 fission yeast
Q8X021        97 -----------QTESLFVAGTIFITICQYGIPntgpw--------------llkaMEIIFWIYVGLSFSISAFLYlllws 151 Neurospora crassa
Q2USN1        88 -----------SNETHFVGTCLLAFATIIIGAesygtsac--------gpwlqvaLRIVFWIYVAISIIEAIFHNwylyh 148 Aspergillus oryzae
XP_385382    110 ktpqsrkiglrDRIACYQWTYFTLISSSSGEFhtffhrsdritiylsicpwllnaMEWVFWVYAALSVSVSAFLYlilws 189 Gibberella zeae...
XP_003033680 100 -----------PVKGIFVPLVVLSFATIIIGTinyavps---------ghvhpgfIYALFWVYVTFALVTCIPMLmiwyn 159 Schizophyllum c...
XP_002910709  65 -----------PAKSVFVPLFVLSFANIIIGVihywh-------------ldgtsAYILLWIYVGLAVLICLPLLvvwfn 120 Coprinopsis cin...

Feature 1                                                                                        
P50537       163 nhvytietasPAWILPIFPPMICGVIAGAVNStqpahq-----------lknmvIFGILFQGLGFWVYLLLFAVNVLRFF 231 fission yeast
XP_001262348 200 tqtftiaqmtPIWIFPAYPMLIIGPHAGILSAklepsr-----------alpiiIGGTTIQGIGLLVTLTVYSAYVYRLF 268 Neosartorya fis...
XP_001397338 162 tgtnhgdhfaIVNILPYFPPMLSGTMAGVLAPnqdpaq-----------avpmlVGGTTMQGFGFLMFLVILVQSLTEIS 230 Aspergillus nig...
Q4P299       161 raeqslhhmnPAWVLPIFPAMLCGTIASSVVPmqspsa-----------alaiaVCGLTCQGLGFIVSIMMYAVLLLRLM 229 Ustilago maydis
O59815       159 ahpfrintiiPALVLPIFPCMICGVIASAIVEsqparq-----------aknmvVAGIAFQGLGFWIYIIVYAVNMCRFF 227 fission yeast
Q8X021       152 ttvfpihtmtPVWVFPAYPLLLTAPYGANLIAaavksghltragqstinpisiaLASVAVQGTGFLISFMICAAFLYRLM 231 Neurospora crassa
Q2USN1       149 hsmaseqpfaLVRLLPSFPAMLSGTIASVIASnqpqkh-----------alpiiIGGTTLQGFGFLMSLFIYGEYFYRLN 217 Aspergillus oryzae
XP_385382    190 tlifpvhtmtPTWVFPAYPLLLNAPFAANLIAaaessghkm-----tvntvamaLGATAIQGTGCLIAFMISSAFIYRLM 264 Gibberella zeae...
XP_003033680 160 qp-hdlthftPAYAFLVFPMMLVGVVAFNVLNvmdptdp---------asvgvlLVGYFFQGLGFFMTFFYICIYIIRVM 229 Schizophyllum c...
XP_002910709 121 qp-hdlyqftPASAFLANLSNAYNVLDVMDYNesrs--------------igvlLVGYFFQGLGFFMTFFYICIYILRIF 185 Coprinopsis cin...

Feature 1                                                                                        
P50537       232 tvglakpqdRPGMFMFVGPPAFSGLALINIargamgsrpyifvg------------ansseylgfvstfMAIFIWGLAAW 299 fission yeast
XP_001262348 269 sqklprenvRPGMFVSVGPSAFTVSGLVTMaahakrcfpddfmgn----------galaanilevvvnfACLWLWGLAIF 338 Neosartorya fis...
XP_001397338 231 seglpvpnfRPEMFIAVGPPSFTIIAMISMadaaveklpdhyisaa--------tsvrtadvllivavvASVFLWLLAFF 302 Aspergillus nig...
Q4P299       230 thsyppsraRPGLFMNVGPPAFTIICLLGLssemqrilpalsssvs--------lpansyeilsvtalaASVLLWSLSAW 301 Ustilago maydis
O59815       228 tvglqpaadRPGMFILVSPPSFTGLTLLDLafgakakrpyifvg------------dnsseylefvatfMALFMIGLGIF 295 fission yeast
Q8X021       232 tqklprdyqRPGVFISIGPGAFTAAGLVQLansapdffpteflgt---------qgavaisilrmlaymAGIWLWGLSCW 302 Neurospora crassa
Q2USN1       218 ksglpkpseRPEMFIAVGPWSFTALALIGManaavekfpvryiisyadsshsetvtvttgdialviaalAGIFLWTIAFF 297 Aspergillus oryzae
XP_385382    265 tqklprdnqRPGIFMSIGPYGFTAAGIAQLgsqadllvpenflg-----------asnvadiikvisilVSLWLWGLALW 333 Gibberella zeae...
XP_003033680 230 ttgfleghqANGAFVACGPPGFTALALINLadhaqnilhahnlv-----------spmageiwyatsvmSGLLLYGLAVF 298 Schizophyllum c...
XP_002910709 186 l--------VGGALIVCGPPGFTALAIIQLgdrarsilpahnli-----------tvnsgeiwyagsvmGGLMLFGLAVF 246 Coprinopsis cin...

Feature 1                                        #                                        
P50537       300 CYCLAMVSFLAGFftrapl---kfacgWFAFIFPNVGFVNCTIEIGkmidskAFQMFGHIIGVILCIQWILLM 369 fission yeast
XP_001262348 339 FFFIATFAHWSTIgpgrm----nfsmaWFSFVFPNTALITATFAIGnafsckPILIIGCAMIFPLILMYIFVF 407 Neosartorya fischeri N...
XP_001397338 303 LFCMAALSMLEALwhrti----rfeliWWCMVFPITGFVLATIDMGeylaspAIEWVGSGMTIFQVCLWLTIT 371 Aspergillus niger CBS ...
Q4P299       302 FYLFTVASLIDVMlskkkrgemefilaWWACVFPVSGFVLATQELGeafnstAINVVAQCMLVWLVIVFVMVA 374 Ustilago maydis
O59815       296 NFCLAFVSVVAGFctrqri---kfkvsWFAMIFANVGLVMDVQELGraidskAVCIVGQVCGVTITIVWIILI 365 fission yeast
Q8X021       303 FFLVSVGSLWKYLrperksk-lqfqmtWFSFVFPNTALVTATEQLGkafesdGLKILGCVLTGCIIVVWIVVF 374 Neurospora crassa
Q2USN1       298 CLCIAIASVLALCkafggagapgmslpYWSMVFPNTGFVIATIRIGqvlqseAVLWVASAMTILQVAIWLIAS 370 Aspergillus oryzae
XP_385382    334 FFLVCVGALWKYTrsghhm---pfqmtWWSFVFPNTALVTATSVMGkvfdnnGLHIFASVMTVAIIIVWIIIF 403 Gibberella zeae PH-1
XP_003033680 299 LFFFGILPYWFKLhkhln-----eilgCWALTFPNVGWISTTRLLGdifhvqGLFVVHLFMAVVMCIAWAVLF 366 Schizophyllum commune ...
XP_002910709 247 LFVFGAFPFWFKTnkrlh-----dilgCWALTFPNVGWILTLRVLGnlfdidGFKILHLVCCFILAVVWLILF 314 Coprinopsis cinerea ok...

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