3M7L,3M71


Conserved Protein Domain Family
TDT
?
cd09299: TDT 
Click on image for an interactive view with Cn3D
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane alpha-helical spanners (TMSs).
Links
?
Statistics
?
PSSM-Id: 187756
Aligned: 17 rows
Threshold Bit Score: 158.26
Created: 19-Nov-2009
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
gating
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:gating phenylalanine in ion channel
Evidence:
  • Comment:Mutational and structural studies in Haemophilus influenzae TehA (HiTehA) show that this residue plays a crucial role in gating of the anion channel
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
3M7L_A         13 YFGIPLGLAALSLAWFHLenl----fpaARXVSDVLGIVASAVWILFILXYAYKlryy--feeVRAEYHs-PVRFSFIAL 85   Haemophilus i...
3M71_A         13 YFGIPLGLAALSLAWFHLenl----fpaARMVSDVLGIVASAVWILFILMYAYKlryy--feeVRAEYHs-PVRFSFIAL 85   Haemophilus i...
YP_023715      10 WFGPVVGTLSVSLTLYLIslvy--nnsiIFRIGSYVYYLDLFIFFFVLVSLFYYyisg-ngniIDDSFN--IQKFPFFGF 84   Picrophilus t...
Q6L253         11 SEWFGMAIATLAVAQTFFlasrymenitLKYTGEIFFYLGIIIFLVIFILWTIRglt---ihdKKWSHWnnLTRLSFIAL 87   Picrophilus t...
Q5P637         26 YFGMVMATGIISLGAHLLa---------LPRLAQGLFVLNVGIYGVIAVLFVLRmirfpqrffGDMVDH--LRGPGFFTA 94   Aromatoleum a...
Q5EAK4          1 MATGGVGLIIGSFPFRFYg---------LNTIGKIVYILQIVLLTLFGSCMLFRfiky--pstIKDSWNh-HLEKLFIAT 68   fission yeast
A0AVZ8         47 WFASIMGTGIVATAAATLplq----fpgLRTGATVVWALASMLLILLTTATVVHwir---hreTAQSHHshPVMAHFYGA 119  Arthrobacter ...
ZP_05569992    10 WFPVVLGTLSVSLAFFIIylvf--hnvlIFNIGKIIYFIVLIFFAFVFASWIYRyikn--kklIKEDYNd-MTKLSFLAF 84   Ferroplasma a...
YP_003186306   11 WFTTVMGIGIVAALTYTSpih----lpfQHAVGEILFIGVNVVFVFAFAMWILRwllt-pdaaIDDFRH--PGRALFYGA 83   Alicyclobacil...
ZP_06976068    35 WFSCVMGTGILAICMTLSpve----iplIEYAALGLWIVDVVLFVFLLLIWGLHhtry-pvlkGRRLHS--FIYAQSLGA 107  Ktedonobacter...

Feature 1                                                                                         
3M7L_A         86 IPITTXLVGDILyrwn-----------pliAEVLIWIGTIGQLLFSTLRVselwqggvfeqksthPSFYLPAVAANFTSA 154  Haemophilus i...
3M71_A         86 IPITTMLVGDILyrwn-----------pliAEVLIWIGTIGQLLFSTLRVselwqggvfeqksthPSFYLPAVAANFTSA 154  Haemophilus i...
YP_023715      85 IGILYFALAFFFyayigin-----rdiafiMLYLYYFFYAYMIILNLLLSyriytga-ikyeniaYTSLIPIISLAGNII 158  Picrophilus t...
Q6L253         88 VPIILFVINHITielyginel-marlslynYFFSYFLALILGVLLGYRIYtkein-----rneinYAIIIPPLSIGTSIF 161  Picrophilus t...
Q5P637         95 VAASGILGSQFLiladsea----agltlwfVAIALWIGLTYTIFTAFTVKeqkptl----drgisGGWLLAVVATQSIAV 166  Aromatoleum a...
Q5EAK4         69 CLLSLSTFIDMLaiyayadtgewmvwviriLYYIFVAVAFIYCVSAFFTIfnnhvy---tietasPAWILPIFPPMICGV 145  fission yeast
A0AVZ8        120 PPMALLTVGAGTlllgkdvl--geqlalgiDTVLWVAGTVLGLASAVAVPylqftrhqvtqdsafGGWLMPVVPPMVSAS 197  Arthrobacter ...
ZP_05569992    85 LGIFYYAFAFFYvayvgvn-----afvaylFYYLLFLFYILVLVINIILNynlytnk-ysfdritYAILVPNVVMSANII 158  Ferroplasma a...
YP_003186306   84 FAMGINVVGNDYfligthmm--pkhtaiaiSFAIWLAGVAASVFSVIVVPyllftehkverdetvASWLIPLVPPIVAAA 161  Alicyclobacil...
ZP_06976068   108 PPMACFTIASGFmligqevl--dpslcvlvAQILWVCGVLGSLFSAVVVPyfmfthhnlnaeqtyGSWLLPVVPLIGAAV 185  Ktedonobacter...

Feature 1                                                                                         
3M7L_A        155 SSLALLgy---------------hDLGYLFFGAGXIAWIIFEPVLLQHLRissl-epqfRATXGIVLAPAFVCVSAYLSI 218  Haemophilus i...
3M71_A        155 SSLALLgy---------------hDLGYLFFGAGMIAWIIFEPVLLQHLRissl-epqfRATMGIVLAPAFVCVSAYLSI 218  Haemophilus i...
YP_023715     159 LSSILMpptldyfinyrdilismyMLIMAGTGIAVLQFIFIGNISIMAHMnng---rqkAPATMIPLGASSMIAINLLFM 235  Picrophilus t...
Q6L253        162 LATPLIgyyhgt------iaesiyFLVLMGLGIFFFLYIFIGSVALSGHVsnks--gssLPTAMLPVGVSSLIIINLISI 233  Picrophilus t...
Q5P637        167 LGALLAnhleqp------yrlelnFLALSMWLWGGMLYIWMMSLIFYRYTfflfspgdlAPPYWINMGAMAISTLAGSLL 240  Aromatoleum a...
Q5EAK4        146 IAGAVNatqp-----------arqLKNMVIFGILFFFFFFFFHISTAMVV---------ASEIAKVASKTARDIAGCFTC 205  fission yeast
A0AVZ8        198 TGALLLpyvpagq-----arlsllMGCYAMFGLSLLASIIITTLIWNRLAghkigaaaaVPTLWIVLGPLGQSITAANLL 272  Arthrobacter ...
ZP_05569992   159 LTSIMLtppmsgyyn-ttilrtvyFMVMVAFGISFFQFLFVGISAYISHIsnkpnylqtVPAAMIPVGASSMLIINIMFM 237  Ferroplasma a...
YP_003186306  162 TGTNLIpyaggpg-----aqfsmtAGIVALFGMTFFLFIMTSALVYSRLVfhrrlsgqeAPTLWIEIGPIGMAMGTFCGI 236  Alicyclobacil...
ZP_06976068   186 PSAMLVkywpts------lhleilMLNYVLWGTGMVLAAIVIVLFYSRLVyhkvpqgalVPTLWLVIGPLGQSTTAILAL 259  Ktedonobacter...

Feature 1                                                                                         
3M7L_A        219 nhge---------------------------------------vdtLAKILWGYGFLQLFFLLRLFPWIVekgl-----n 254  Haemophilus i...
3M71_A        219 nhge---------------------------------------vdtLAKILWGYGFLQLFFLLRLFPWIVekgl-----n 254  Haemophilus i...
YP_023715     236 pifnklkif----------------------------yvpeylavdVSTMLWGFEVLSFLTGLVMAIFHFrnkp-----s 282  Picrophilus t...
Q6L253        234 nsfgavidhl---------------------------pfsiytvefVSILLWGFEVWNFLVMMIIVFRKEtfg------y 280  Picrophilus t...
Q5P637        241 ianapdapfl---------------------------hsllpflkgFTVFYWATGTWWIPMLLILGLWRHvykrfplkyd 293  Aromatoleum a...
Q5EAK4        206 qcgtqfdnverivqhfkecryrdetckdddivvyepssfvqdekkdKPIIVEAASEATSEEACNSSKERQlpa------- 278  fission yeast
A0AVZ8        273 ggnahlavsgt------------------------laqamealgvlYGVPVLGFALMWAALATAITIRTArrglp---fs 325  Arthrobacter ...
ZP_05569992   238 pqfnyigif----------------------------nvppnlaidISVILWGFDLFLFLVSGAIAITHIkkrq-----s 284  Ferroplasma a...
YP_003186306  237 plnaphvfgpy-------------------------fgglrdlgavFSIAMWGVGVWWILLSALYTFLHLtpkgdglpfh 291  Alicyclobacil...
ZP_06976068   260 gkqarnhlpsf-------------------------adilqgggvaYGLVAWGFGLYWLALAIMMTLRAArvhlp---fn 311  Ktedonobacter...

Feature 1                #                                                        
3M7L_A        255 igLWAFSFGLASXANSATAFyhgn----------------vlqGVSIFAFVFSNVXIGLLVLXT 302  Haemophilus influenzae
3M71_A        255 igLWAFSFGLASMANSATAFyhgn----------------vlqGVSIFAFVFSNVMIGLLVLMT 302  Haemophilus influenzae
YP_023715     283 vaTWAYVFPSGISTFANYLLyi-------------------etGLQLFKYSILIISIGVYGLYI 327  Picrophilus torridus DSM 9790
Q6L253        281 lsVWAYGFPLGLFATSTIKLee-------------------vtKIVILGNIFIFIWVALVLLWF 325  Picrophilus torridus
Q5P637        294 plYWGAVFPLGMYAASTQQMagam----------------gfdFLGFVPPIFLYAALAAWSAAF 341  Aromatoleum aromaticum EbN1
Q5EAK4        279 lsALSALSTLTTSANDDLWTarliwqstndtkldnspssnytdLNHKLANYGLSILSIHALMCV 342  fission yeast
A0AVZ8        326 ltWWSFTFPIGTCVTGLTGLaaht----------------hlaVFDAMAVAGYTLLVAAWIIVA 373  Arthrobacter sp. FB24
ZP_05569992   285 mtVWAYVFPVGVSTFADYMIyd-------------------ytKLEIFVYSIIAFTAALIILYV 329  Ferroplasma acidarmanus fer1
YP_003186306  292 lgWWSYVFPIGSFTNGTYALhrllg-------------hpffaVAGLVQLGILWLCFAIVIVRT 342  Alicyclobacillus acidocaldari...
ZP_06976068   312 lsWWSFIYPLGVMTTGTYALyehv----------------ptyLFMGCGLVLLFLLTVLWLVVS 359  Ktedonobacter racemifer DSM 4...

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap