3OL2,3OKW,3AL8


Conserved Protein Domain Family
Sema
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cd09295: Sema 
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The Sema domain, a protein interacting module, of semaphorins and plexins
Both semaphorins and plexins have a Sema domain on their N-termini. Plexins function as receptors for the semaphorins. Evolutionarily, plexins may be the ancestor of semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems, and cancer. Semaphorins can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. Plexins are a large family of transmembrane proteins, which are divided into four types (A-D) according to sequence similarity. In vertebrates, type A plexins serve as co-receptors for neuropilins to mediate the signalling of class 3 semaphorins. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B plexins. This family also includes the MET and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves to recognize and bind receptors.
Links
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Statistics
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PSSM-Id: 200495
Aligned: 5 rows
Threshold Bit Score: 361.137
Created: 19-Nov-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3OL2_A     28 NYSALLLSedk--------dtLYIGAREAVFAVNAlnis---------------ekqHEVYWKVsedkkakca----ekg 80   human
3OKW_A     42 DIQMIMIMnr----------tLYVAARDHIYTVDIdtshte-----------eiycsKKLTWKSrqadvdtcr-----mk 95   house mouse
3AL8_B     19 TFNHLTVHrrt--------gaVYVGAINRVYKLTGnlt-----------------iqVAHKTGPeednkacypplivqpc 73   house mouse
CBY13975   77 DDKEFLISghkey---fsiaeIPFRPHVKEYFPDGsstietqs-------hvsarisCERAFGKfs-------------- 132  Oikopleura dioica
XP_418232  14 DDDKIYVFftetavefefydkILVSRIARICKGDLggkrllqrrwtsflkarlscsiPELNFHFniiqdvff------lr 87   chicken

3OL2_A     81 kskqteCLNYIRVLQPLsa----tSLYVCGTNaf----qPACDHLnltsfkflgkne---------dgkgrcpfdpahSY 143  human
3OKW_A     96 gkhkdeCHNFIKVLLKKnd----dTLFVCGTNaf----nPSCRNYrvdtletfgdef---------sgmarcpydakhAN 158  house mouse
3AL8_B     74 sevltlTNNVNKLLIIDys---enRLLACGSLy-----qGVCKLLrlddlfilvepsh-------kkehylssvnktgTM 138  house mouse
CBY13975  133 ----ehCSNYITSISQKtddseklQFQVCNSNfa----qPKLETWkidlenyndkltkavsketefstanscpasfksST 204  Oikopleura dioica
XP_418232  88 rgkwqdSIFYGIFSQQWgr---ldISAVCAYSmasiqeaFSKGSYrgpvtvehshvrwmvfrgevpvprpgacidnfaRN 164  chicken

3OL2_A    144 TSVMVdg-----eLYSGTSynfl-------------gsepIISRNSsh-----------------spLRTEYAipw---- 184  human
3OKW_A    159 IALFAdg-----kLYSATVtdfl-------------aidaVIYRSLgds----------------ptLRTVKHdsk---- 200  house mouse
3AL8_B    139 YGVIVrsegedgkLFIGTAvdgkq------------dyfpTLSSRKlprdpessamldyelhsdfvsSLIKIPsdtlalv 206  house mouse
CBY13975  205 LTKWIds-----tMRVAAIglhkevksgspvvsvfafekeAFSTKEakvn-------------lfhdARFMLIssn---- 262  Oikopleura dioica
XP_418232 165 MGYNTssdlpdkvLQFARDhplmdssv------npigdrpALLKRSsn------------------yTRIVVDrvt---- 216  chicken

3OL2_A    185 -lnEPSFVFADVIRkspds--------pdgedDRVYFFFTEVsveye-----fvfrvLIPRIARVCkgdqgglr-tlqkk 249  human
3OKW_A    201 wlkEPYFVQAVDYG------------------DYIYFFFREIaveyn-----tmgkvVFPRVAQVCkndmggsqrvlekq 257  house mouse
3AL8_B    207 shfDIFYIYGFASG------------------GFVYFLTVQPetpdgmainsagdlfYTSRIVRLCkddp---------k 259  house mouse
CBY13975  263 -ieQIHFLYSDVSSap---------------dDDSEAFFRQN---------------SRPKIASICrsgf--------ei 303  Oikopleura dioica
XP_418232 217 gldKQTYDVMFLGTddgylhkafncngemfivEELQLFLSPEpvqflql-sakkgmlYVGSMSAVVqlqvsgch-rykyc 294  chicken

3OL2_A    250 wtSFLKARLICsrpd-sglVFNVLRDVFVLrspg---------lkvPVFYALFTPqln----nvgLSAVCAYNLSTAEEV 315  human
3OKW_A    258 wtSFLKARLNCsvpgdshfYFNILQAVTDViri----------ngrDVVLATFSTpyn----sipGSAVCAYDMLDIANV 323  house mouse
3AL8_B    260 fhSYVSLPFGCtra---gvEYRLLQAAYLAkpgealaqafnissdeDVLFAIFSKgqkqyhhppdDSALCAFPIRAINLQ 336  house mouse
CBY13975  304 lnEFHLGDLNCkee---dfDFPIFVDAVETe---------------LHIFGIFQSrar----kyqKNAICRFEKADLGKL 361  Oikopleura dioica
XP_418232 295 ldCILARDPYCawsq-ashACVLLSDQTGDtkn----------liqNVKYGDASScl------svENDVRKYLFTLGNNV 357  chicken

3OL2_A    316 FshgkymqsttveqshtkwvryngpvpkprpgacidsearaanytsslnlpdktlqfvkdhplmDDSVTpid-------n 388  human
3OKW_A    324 Ftgrfkeqkspdstwtpvpdervpkprpgcc----agssslekyatsnefpddtlnfikthplmDEAVPsii-------n 392  house mouse
3AL8_B    337 Ikerlqscyhgegnlelnwllgkdv---------------qctkapvpiddnfcgldinqplggSTPVEg---------- 391  house mouse
CBY13975  362 Sktiss-----------------------------------------------------vqcseNDPTEylnirsrssvn 388  Oikopleura dioica
XP_418232 358 Hlkcvplsnlarvvwkfngsriqdkdskyll---ydggiaifnvtvaetgfydclsvekskakeFFITVar--------- 425  chicken

3OL2_A    389 rPRLIKk-----------------------dVNYTQIVVDrtqal-----------------------dgtvYDVMFVST 422  human
3OKW_A    393 rPWFLRtm---------------------vrYRLTKIAVDnaag------------------------pyqnHTVVFLGS 427  house mouse
3AL8_B    392 lTLYTTs-----------------------rDRLTSVASYvy----------------------------ngYSVVFVGT 420  house mouse
CBY13975  389 gELVMSprds------------------seyGAFTSITVDaektenfplifigteegillktakfeefssleKLEYPWQL 450  Oikopleura dioica
XP_418232 426 yALYAHqntekanvnaatddnneaeavgfqsSLSTYLLKDatkq------------------------ksvgSQKENLLL 481  chicken

3OL2_A    423 DRGALHKAIsleh-------avhIIEETQLFqd---------fEPVQ-TLLLSSkkgnrfVYAGSnsGVVQAPLA 480  human
3OKW_A    428 EKGIILKFLarigssg-flngslFLEEMNVYnpekcsydgvedKRIM-GMQLDRas--gsLYVAFstCVIKVPLG 498  house mouse
3AL8_B    421 KSGKLKKIRadgpp-----hggvQYEMVSVFkd---------gSPILrDMAFSInq--lyLYVMSerQVTRVPVE 479  house mouse
CBY13975  451 VEAYNIEKMakna------vkleSISDDWVIkk--------ihFRYD-KLGALRlp---yVYVATdsCVLAVKVQ 507  Oikopleura dioica
XP_418232 482 KLLSAGFALlffflfiwnfykghISLPWKIRea---------sSKDT-NADLENp----eLTTGRegGSLGARTQ 542  chicken
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