Conserved Protein Domain Family
PLDc_unchar4
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cd09132: PLDc_unchar4 
Putative catalytic domain of uncharacterized phospholipase D-like proteins
Putative catalytic domain of uncharacterized phospholipase D (PLD, EC 3.1.4.4)-like proteins. Members of this subfamily contain one copy of HKD motif (H-x-K-x(4)-D, where x represents any amino acid residue) that characterizes the PLD superfamily.
Links
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Statistics
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PSSM-Id: 197230
Aligned: 20 rows
Threshold Bit Score: 111.983
Created: 20-Apr-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
putative activeputative
Feature 1:putative active site [active site]
Evidence:
  • Comment:based on similarity with Salmonella typhimurium EDTA-resistant nuclease Nuc
  • Comment:The HKD signature motif (expanded to H-x-K-x(4)-D-x(6)-G-S-x-N, where x represents any amino acid residue) characterizes the PLD superfamily.
  • Comment:Most residues in the HKD motif are part of the active site.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
YP_986446    107 EQALLQVIn--aAEQTLFITSFVAyd----vSTIVKALNAAn--dRGVVISMLLELSQdhggsis----------fdaig 168 Acidovorax sp. ...
ZP_05039492  102 RVVVKELFd--sVNKSVLISSYALdtg-hkaKALFQPLAQRmsdkPDLQVRLFVNINRpygknsqsdavllrefsetfrr 178 Synechococcus s...
YP_876549     73 EPVIVELLksakRGERVLIVGYRIth---gaASIIQELNSCl--kTGILVDLVVDSSSvndrel-------------skc 134 Cenarchaeum sym...
ZP_04125162  103 HATVKRLFq--aAKMNILVVGYTFsleqepvNLLFQELVSAs--eRGCRIDIIYHNDEknlen--------------ikq 164 Bacillus thurin...
YP_001501137 119 EAVVNEIVa--sAEIELLIVGYWLvtsteqiKSLIESLVQKa--hKGIRVRFVFDPNEksgspdnfa-------alnnlw 187 Shewanella peal...
ZP_01080504   82 FATVDQLIq--eAQTSLLIATYNIgls-nqfQELLESIADRllsgRLQRVELFFHPIQiadqlgseplr---mirqwfdk 155 Synechococcus s...
ZP_03288690   87 KDTMRNLIe--nTEKSLTITGYSIsd---yfTEMLDVIIKKs--qQGVYVRLYVNDTEkqkev--------------ldr 145 Clostridium nex...
YP_001613876  99 TAVVLRSLfe-gAQESVLLAGYSFdh----aEDVLAPLYGAmq-nRQIEARFFIDIPQierrasadahlt-ryfskflte 171 Sorangium cellu...
YP_637990     84 TLAALDMIn--gATAFIYAATYSAgk----kSPHLLALRHAi--dRGVMVTVVVDVKEradh----------------ae 139 Mycobacterium s...
ZP_06751561   73 TMTVVQSMle-gVKRNILITGYSLss---yfSELTDTIIEKs--qKGVFVKFFINNVEkqpdv---------------dk 131 Parascardovia d...

Feature 1                                         # #                # #          #     
YP_986446    169 kmSTLVSAARLYSWrdkaap-------fsdgrVHAKVAVADg----KMCFITSANLTghAMEQNMEAGVLL 228 Acidovorax sp. JS42
ZP_05039492  179 stWPGSRMPEVFYDprslske-----kapracLHAKCVVIDd----ERLLVTSANFTeaAHQRNIEAGVLL 240 Synechococcus sp. PCC 7335
YP_876549    135 fpKGKLMRPTIYARkekdy---------gkykMHAKVIVVGr----REMLVGSANLTglGTEVNFELGLLV 192 Cenarchaeum symbiosum A
ZP_04125162  165 swPSHLMLPHLYYWkgskk--------skyasLHSKLIMVDq----SRLLLTSANFSlnGFKENIETGVLI 223 Bacillus thuringiensis s...
YP_001501137 188 pvDLKGAPREVYSWsehmakviskrghqydrkLHAKVIVADr----NDALVTSANLThaGILENLEMGLRV 254 Shewanella pealeana ATCC...
ZP_01080504  156 evWPWPAKPLVYVDqrlsss------saercyQHAKVVVADadtdrSSALVTSANFSetAQRHNFEAGWLV 220 Synechococcus sp. RS9917
ZP_03288690  146 lmSYRSRFLQIYEYqkqed--------dkmaaLHAKLIVSDv----KKSLVSSANLSyhGMQGNIEMGFLI 204 Clostridium nexile DSM 1787
YP_001613876 172 swPFGDPRPRLYYDkralap------gppycsLHAKCVVVDs----AKAFVSSANFTqrGQERNIEVGVLI 232 Sorangium cellulosum 'So...
YP_637990    140 mmCNALAGARIWRLaeped--------gewaiQHSKLIAVDd----TALFVTSANFStaGAKRSLECGMLS 198 Mycobacterium sp. MCS
ZP_06751561  132 llRYKGRFLQIYDYsneed---------kmaaLHAKVISVDm----RQTLITSANLSyhGQQGNIELGTLI 189 Parascardovia denticolen...

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