Conserved Protein Domain Family
PLDc_unchar3
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cd09131: PLDc_unchar3 
Putative catalytic domain of uncharacterized phospholipase D-like proteins
Putative catalytic domain of uncharacterized phospholipase D (PLD, EC 3.1.4.4)-like proteins. Members of this subfamily contain one copy of HKD motif (H-x-K-x(4)-D, where x represents any amino acid residue) that characterizes the PLD superfamily.
Links
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Statistics
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PSSM-Id: 197229
Aligned: 11 rows
Threshold Bit Score: 155.962
Created: 29-Jun-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
putative activeputative
Feature 1:putative active site [active site]
Evidence:
  • Comment:based on similarity with Salmonella typhimurium EDTA-resistant nuclease Nuc
  • Comment:The HKD signature motif (expanded to H-x-K-x(4)-D-x(6)-G-S-x-N, where x represents any amino acid residue) characterizes the PLD superfamily.
  • Comment:Most residues in the HKD motif are part of the active site.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
YP_002308111  116 DNEYYYEVLNTINNAGESIYVMMFSMKYDPadsf--dwaNDLIRALAEAe-KRGVSVHVLLEDSsdi------------- 179 Thermococcus o...
BAI81297       46 DDKLLKPMIQDIENAKKNIYIAIYMFKTDDykf---nlsNLIEEALYDAl-DKGVKVYVVFDKGkkddit-------tef 114 Deferribacter ...
YP_003482898   50 DREYYPVVIEKINNANVSIHIVMFEMKWYGnpdkdthkvSALGRALVAAe-KRGVDVKIILDDGkgygfenp---qmvew 125 Aciduliprofund...
YP_002427808   50 DREYYDAVLRTLGGANRSVYIMMYVVKYDPnerg--dpvNILLETLEKLk-NRGVDVKIVVDDEtyks-----------y 115 Desulfurococcu...
jgi:Aboo_0127  50 NYGYAPMLKHLIDNATESVYVSMEILSDYEp-------vKTLLDSLIAAh-NRGVDVKVICEGDiss------------- 108 Aciduliprofund...
CAJ72833       44 DQEYYFHVHRAMKDAKNSIFCVMYSANINPkypk--skeYQLLDGLVDAh-KRGVAVTVIFEKNiafwekgakgktvekk 120 Candidatus Kue...
YP_001229002   49 NQEYADALLKGIRDARRSIVFSFYLFKVTEsrg---nqpRIITAELIKAa-MRGVDVTVFLEKGndkndql------nge 118 Geobacter uran...
ADH86106      194 DQEYYPALLHLLQGAARRVELAMFVFRATEaag---nrpARIAEELINAg-RRGVEVKVILEHSaydeel-------tqe 262 Desulfurivibri...
YP_920430      47 DRDYYPTLLDYISRANKSIYIAMFQFKSDTdv------iSKIVELLISKn-KKGVDVKVVLENTide------------- 106 Thermofilum pe...
YP_003503056   45 DSELETALAKDIANAQNSIYAAMYMFKSYDnis---rgaGLLKKSITDAa-DRGVSIYVALEASdggdfv-------dte 113 Denitrovibrio ...
ZP_04875262   209 DGYTYNALKDLINSAKHRLYISVYTMAYYSnpe----gnETLVNNLVNEiiEKRDIAKVVLDDHds-------------- 270 Aciduliprofund...

Feature 1                                  # #            # #           #                     
YP_002308111  180 nqaAYDYLKANGVDVSFDSpe-tTLHAKVVVIDgkTVFLGSHNWSESALy-WNHEVSIKIVSEDLAQSLINYFWSI 253 Thermococcus onnur...
BAI81297      115 nmdTAEELKRRGAVVRFDSpk-rRLHSKLMVIDkrIVYIGSHNYTHSALk-YNNETSVRIESADVANEAIKYIKGI 188 Deferribacter desu...
YP_003482898  126 aqnWKAYFESHHIQVKFDWsn-qTTHDKLVIIDhkIVIVGSTNWSTSALd-YNHEADAIIESKEVAQQYENYFNSL 199 Aciduliprofundum b...
YP_002427808  116 kdtTIRYLLSNNIPVRLDEssaiTTHTKMVIIDnsTVILGSHNWTESALm-NNHEASIETNCTSIVSKALSYFDNI 190 Desulfurococcus ka...
jgi:Aboo_0127 109 nkyGVQYLENGGVEVKVDNtq-kFIHTKMVVIDgkVVYVGSHNWSPYALg-KNNEYGILIFNSQIADFYQNYFDSL 182 Aciduliprofundum b...
CAJ72833      121 spkAYEFLKEKGVPVFYDSvk-nITHSKILVIDnyVTILGSTNWTYSALn-KNHEASVLIKSRSVAESFLAKLNKI 194 Candidatus Kueneni...
YP_001229002  119 nrdTAALLAKGGVKVFFDSpr-vTSHMKTVVIDgrYVYIGSHNLTQSALq-RNNELSVLIDSPEMAAEIKAYLDRL 192 Geobacter uraniire...
ADH86106      263 hrrLARNLRQGGVEVRFGPrd-tTTHNKIILIDerFTLLGSHNLTHAALs-RNHECSLLIDSRELAARLSAYLSQL 336 Desulfurivibrio al...
YP_920430     107 nelTYRRLLDNGVAVKFDSrs-vTTHAKLVIIDgrYVFVGSHNWSYMAMm-RNHEASVLIDCPSIAEQETQYFMNI 180 Thermofilum penden...
YP_003503056  114 nkkTGTEFSKHGIKVVYDKpd-nRMHTKCLVVDgeITYIGSHNYTNSALk-YNRELTARIVSPETAKDAIRHIKSI 187 Denitrovibrio acet...
ZP_04875262   271 -dnAYNYLQDNYVSVEYDSss-vTTHLKLVIADd-TVYVGDANWDYGYLdnETHTVGVIIENKTVADFFANYFLQI 343 Aciduliprofundum b...

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