Conserved Protein Domain Family
INPP5c_INPP5J-like
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cd09094: INPP5c_INPP5J-like 
Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins
INPP5c domain of Inositol polyphosphate-5-phosphatase J (INPP5J), also known as PIB5PA or PIPP, and related proteins. This subfamily belongs to a family of Mg2+-dependent inositol polyphosphate 5-phosphatases, which hydrolyze the 5-phosphate from the inositol ring of various 5-position phosphorylated phosphoinositides (PIs) and inositol phosphates (IPs), and to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. INPP5J hydrolyzes PI(4,5)P2, I(1,4,5)P3, and I(1,3,4,5)P4 at ruffling membranes. These proteins contain a C-terminal, SKIP carboxyl homology domain (SKICH), which may direct plasma membrane ruffle localization.
Links
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Statistics
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PSSM-Id: 197328
Aligned: 9 rows
Threshold Bit Score: 432.564
Created: 17-Jun-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:putative catalytic site [active site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 #                                           #                           
Q15735        423 FRITVVTWNVGTA--MPPDDVTSLLHlggg--------ddsdGADMIAIGLQEVNsmLNKRLKDAlFTDQWSELFMDALg 492  human
NP_001082962    4 FGLYVVTWNVATA--EPPDDVNALLQlns-----------pkKPDLYVIGLQEVRaaPLKFVSDLaFEDSWSHLFMDTLs 70   zebrafish
CAG31251       17 LRLHLVTWNVGTA--SPPPDVTSLLQlds----------pspAIDLYVIGLQEVNsrITNFLSDLvFDDPWSIFFMTVLs 84   chicken
AAH73616       49 LRLHLVTWNVATA--SPPRDVRSLLQldi----------pgsDIDMYIIGLQEVNskVLNFLSDLaFDDPWSIYLMDILa 116  African clawe...
XP_780987       4 LRICVSTWNVAIQe-PPPIEAFKDIIwiq----------tqnAPDMYIWGLQEVSskPHEFIQSAfSDDPWTEVISSIVc 72   purple urchin
NP_573135      31 YRVYVVTWNVGSRf-PDNISLRHLLGlqdvtvdkdtketnahLPDIYALGLQEVNaqPQQQVLGLfKEDPWTHKAKELLr 109  fruit fly
ABR27973       27 RSVYVVTWNVAEK--DPPGSVKELLGqvsd--------ssevNPDIVIIGLQELTmnPVQAVVNNiFKDKWSDDFNEILk 96   Triatoma infe...
XP_002122078    4 LKVFACTWNVGNSepIDEKQLQNLLGwqs-----------gvRSDIYIIGLQEIStgPVETAISFiSHDVWAKSFLDFFs 72   Ciona intesti...
XP_002734137    4 FRVYACTWNVATLdpPSPELLRELLHcqeee------egeekEPDLYALGFQEVSakPHHFVRDVvVDDPYTDCICKQLs 77   Saccoglossus ...

Feature 1                                                                              #          
Q15735        493 p-fnFVLVSSVRMQGVILLLFAKYYHLPFL-RDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHmdkaeq 570  human
NP_001082962   71 p-lhYIKVSSIRMQGLLLLFFSKLEHVPFI-RDIQVTYTRTGLYGYWGNKGGVTIRLSFYGHMLCFLNCHLTAHmnyasq 148  zebrafish
CAG31251       85 p-lgYIKLSSIRMQGLLLLIFVKHDHLPFI-RDVRTNYTRTGLYGYWGNKGGVTVRMSLYGHTMCFINCHLPAHmenteq 162  chicken
AAH73616      117 p-hgYVKLSSIRLQGLLLLTFVKHQHIPFV-QDIRTNYIRTGLFGYWGNKGGVTVRMSVYGHMICFMNCHLPAHmentnq 194  African clawe...
XP_780987      73 p-kgYVMINSVRLQGLVILLYVRMPHLPFI-HNVQTALTRTGLGGVWGNKGAVTIRFDCYGRSICLLNVHLSPHqdgwek 150  purple urchin
NP_573135     110 n-ydYVAVKTEQMQGLLLSMFVRRQHVEHL-QDIEAEFTRTGFGGIWGNKGAVSVRFTLYGCGLAFVVAHLTAHdhmmde 187  fruit fly
ABR27973       97 srnnYHKVYSESLLGILLKGIVKIKYKDSInKKADATTVKTGLGGMSGNKGAVILKFQLNNRWFCIVNSHLAAHdeklqe 176  Triatoma infe...
XP_002122078   73 k-qeYFMVENVRLQGMSLCVFASIQHLPFI-RFVKASYERTGFSGNWGNKGGVAISFWCYGEKIAVLNTHLHANlevcek 150  Ciona intesti...
XP_002734137   78 p-kgYIKIRDIRLQGLLLLVFVKLQHVPFL-RNIQTNYTRTGLGGLWGNKGAVTVRFGLYGYSVCLVNCHLEAHlegwkl 155  Saccoglossus ...

Feature 1                                         # #                                             
Q15735        571 RKDNFQTILSLQqfqgpgaqgiLDHDLVFWFGDLNFRIEs-YDLHFVKFAIDSDq-LHQLWEKDQLNMAKnt-wpILKGF 647  human
NP_001082962  149 RVDEFEHILDAQnfntkntphvLDHKVVFWFGDLNFRIEd-HGMLFVRNCITSQr-FNLLWPKDQLTMMKqk-evILQKF 225  zebrafish
CAG31251      163 RLDDFEKILEMQfeeen-vpstLDHDVLFWFGDLNFRIAd-YGIHFVRESINNKr-YNLLWEKDQLNMAKkk-eaFLQEF 238  chicken
AAH73616      195 RLDDFERMLDTQqfdddntgniLDHDLVFCFGDLNFRITd-FGIHFIREAINSNk-YNLLWEKDQLNIAKkk-eqFLQGF 271  African clawe...
XP_780987     151 RDKEFQTIISTQefpqcntssiLDHDYVMWFGDLNYRIEd-LSTEAIKFLASPKk-LHVLLEKDQLLNSMrk-kkAFNGF 227  purple urchin
NP_573135     188 RIEDYKQILENHhyhvkryreiYDHDYVFWFGDLNFRLQgsDSSTEVRELVRDEsqHEALIQRDQLYQVReksqlAFQVL 267  fruit fly
ABR27973      177 RIEDYKTINNKRvdf-----cnKPSDFIFWLGDLNFRLQedVEDEKIRNWVQQRk-YADLLKLDQLKINKqt-keIFTDF 249  Triatoma infe...
XP_002122078  151 RIIDFEKILKGIdfne--tcdiLSHDVVLWIGDTNFRIDd-VSRSDVIKLVQEKk-YKTLLKKDQLIKNQrs-hnLLSQF 225  Ciona intesti...
XP_002734137  156 RDRDYSTIIRDQvfencraktiLNHDYVIWLGDLNYRISd-ISIEDVKDVLNRNe-LHILKFKDQLFLSQea-cdAFHDF 232  Saccoglossus ...

Feature 1                                         #                                               
Q15735        648 QEGPLNFAPTFKFDVGTNKYDTsakKRKPAWTDRILWKVkapgggpsp------------sgrkshrlqVTQHSYRSHME 715  human
NP_001082962  226 EEGPLDFQPTYKFDLNSDNYDTsgkKRKPAWCDRILWRVnpkasltentneeepekqqeeeredefplkMTQEYYTSKME 305  zebrafish
CAG31251      239 IEGPLQFKPTYKFDLHSDVYDTsekKRKPAWTDRILWRMkslcqhaskd----------dfseeeqtisVTLNNYISHMS 308  chicken
AAH73616      272 LEGPLKFKPTYKFDQNSDVYDTsskKRKPAWTDRILWKLkdvsgsdpget---------tgsdfeeflkVSLDKYTSHMS 342  African clawe...
XP_780987     228 HEGLITFMPTYKFDLKSNEYDTspkQRSPAWTDRILWKVnlrasi------------------dqnylsITQLSYHAHSD 289  purple urchin
NP_573135     268 QERLPAFPPTFKFREGTSEYDL---KRRPAWTDRIMYAVqplnrq------------------pgmqlsIEQCSYKSHPL 326  fruit fly
ABR27973      250 NEKEITFAPTFKLEKGTGTYST---KRRPAWTDRILYKSdtk-------------------------knITPTLYKSIES 301  Triatoma infe...
XP_002122078  226 IEGEINFAPTYKFDLGTDIYDTsvkQRKPAWTDRVLYRVhpdkvtlrk------------gkseekfvqQIVGSYVSHME 293  Ciona intesti...
XP_002734137  233 SEGDLNFPPTYKLNPGTNEYNVsgkQRKPAWCDRILWKVnkdrir-------------------hvdlnMELVTYNSIQK 293  Saccoglossus ...

Feature 1             ##         
Q15735        716 YtVSDHKPVAAQFLL 730  human
NP_001082962  306 YgISDHKPVIGIFRL 320  zebrafish
CAG31251      309 YgISDHKPVTGTFGI 323  chicken
AAH73616      343 YgISDHKPVTGTFTL 357  African clawed frog
XP_780987     290 IlWSDHRPVSAEFLA 304  purple urchin
NP_573135     327 YtISDHKPVTSDFTI 341  fruit fly
ABR27973      302 YkHSDHYPVQAQFDI 316  Triatoma infestans
XP_002122078  294 MqTSDHKPVTSIFRF 308  Ciona intestinalis
XP_002734137  294 VqWSDHLPVYADFIL 308  Saccoglossus kowalevskii

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