Conserved Protein Domain Family
FAR_C

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cd09071: FAR_C 
C-terminal domain of fatty acyl CoA reductases
C-terminal domain of fatty acyl CoA reductases, a family of SDR-like proteins. SDRs or short-chain dehydrogenases/reductases are Rossmann-fold NAD(P)H-binding proteins. Many proteins in this FAR_C family may function as fatty acyl-CoA reductases (FARs), acting on medium and long chain fatty acids, and have been reported to be involved in diverse processes such as the biosynthesis of insect pheromones, plant cuticular wax production, and mammalian wax biosynthesis. In Arabidopsis thaliana, proteins with this particular architecture have also been identified as the MALE STERILITY 2 (MS2) gene product, which is implicated in male gametogenesis. Mutations in MS2 inhibit the synthesis of exine (sporopollenin), rendering plants unable to reduce pollen wall fatty acids to corresponding alcohols. The function of this C-terminal domain is unclear.
Statistics
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PSSM-Id: 176924
View PSSM: cd09071
Aligned: 246 rows
Threshold Bit Score: 55.2544
Threshold Setting Gi: 74868533
Created: 19-Nov-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7TNT2        355 VSHRVPAIIYDFYLRLT-----GRKPRMLK----LMNRLL----KTISMLEYFINHS-WEWSTNNTEMLLSELSPEDQRV 420  house mouse
XP_001601911  354 IFQMIPAIFIHLFAKLA-----KPEHSLID----IQRRYA----KGGKYTSYFSVRE-WQFSRKTSDELAAMLTEEERDR 419  jewel wasp
ADI60057      391 LKRRLPATALSLVASLP-----GASAAVRRqa-eQTERLVgkmrKLVDTFQSFVFWA-WYFQTESSARLLASLCPEDRET 463  Euglena gracilis
XP_803954     383 LFRELPYYVLRFVANLPnpigsEEKQKLVEr---LGRAVFrs-kDLNRQFRAFVLHE-WVFATAHTELLDDGLNERSRSA 457  Trypanosoma c...
CBH13737      499 LCREVPSHALAFLADLPepigsKSKRENVKk---LKRALFra-kDLNRQFVAFTCTE-WVFAATNTMSLDEGLSERSRSA 573  Trypanosoma b...
XP_001463642  454 LLRYMPYIALRSMMQLPppigsPKKLELVKk---LGRAVRra-dLLTWEFLDFTLNE-WIYAFVNASRLDDGLNEYSRKT 528  Leishmania in...
YP_003267643  454 IDKHLPRWGAPRLTATAe----RVKDRLGR----VSEFTDqa-lELINLFKPFTHDHwLHFRCDNTRALNAQLTPQDQQA 524  Haliangium oc...
YP_002491736  481 LRERAPAWGAPRLSALA-----HRAGEALDe---LTSQLEkt-eAIWAMYLPFTWDNrYVFRCAGMRELRERLSPDDRAR 551  Anaeromyxobac...
ZP_01459699   382 IEEVRPAWGAPTVQALLd----RAKVKLDD----VEEQASsl-sQLIELFLPFLWENrYVFRCDNTRSVYARMLPSDRAK 452  Stigmatella a...
YP_001618662  477 LGGLLKTASVGPAAALL-----KPAAAALEnaarTEQKTA----TLLEVFMPFVAEGdWVYSCANTRAAMARMPPEERAR 547  Sorangium cel...
Q7TNT2        421 FNFDVRQLNWLEYIENy-VLGVKKYLL 446  house mouse
XP_001601911  420 HPMDPRLLDWDKYLEGc-VIGTRTYFH 445  jewel wasp
ADI60057      464 FNWDPRRIGWRAWVENy-CYGLVRYVL 489  Euglena gracilis
XP_803954     458 FYFDTYMINWWFYAQVy-AHGLLKYIV 483  Trypanosoma cruzi strain CL Brener
CBH13737      574 FYYDPYLINWWSYCHWy-SYGLLKHIV 599  Trypanosoma brucei gambiense DAL972
XP_001463642  529 FSFDPYSINWYAYTQVy-AYGIFKHII 554  Leishmania infantum JPCM5
YP_003267643  525 LRWDPDAIDWRSYWLDyhFAGLQKWVF 551  Haliangium ochraceum DSM 14365
YP_002491736  552 IPWDPEALDWRAYWLDvhLKGMEEWVF 578  Anaeromyxobacter dehalogenans 2CP-1
ZP_01459699   453 IPWDPENINWREYWMEthLPGLEKFVF 479  Stigmatella aurantiaca DW4/3-1
YP_001618662  548 FVWAPEKIDWRDYIWNvhLPGLEKWAF 574  Sorangium cellulosum 'So ce 56'
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