1EC6,1DT4,1DTJ,1EC6


Conserved Protein Domain Family
KH-I_NOVA_rpt3

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cd09031: KH-I_NOVA_rpt3 
third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
The family includes two related neuronal RNA-binding proteins, Nova-1 and Nova-2. Nova-1, also called onconeural ventral antigen 1, or paraneoplastic Ri antigen, or ventral neuron-specific protein 1, may regulate RNA splicing or metabolism in a specific subset of developing neurons. It interacts with RNA containing repeats of the YCAY sequence. It is a brain-enriched splicing factor regulating neuronal alternative splicing. Nova-1 is involved in neurological disorders and carcinogenesis. Nova-2, also called astrocytic NOVA1-like RNA-binding protein, is a neuronal RNA-binding protein expressed in a broader central nervous system (CNS) distribution than Nova-1. It functions in neuronal RNA metabolism. NOVA family proteins contain three K-homology (KH) RNA-binding domains. The model corresponds to the third one.
Statistics
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PSSM-Id: 411807
Aligned: 33 rows
Threshold Bit Score: 106.507
Created: 17-Aug-2010
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
RNA bindingGXXG motif
Conserved site includes 22 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 ## ### #####  ##         ####### #    # #                      
1EC6_B          3 ELVEIAVPENlVGAILGKGGKTLVEYQelTGARIQISKKGEFlPGTRNRRVTITGsPAATQAAQYLISQRV 73   human
Q7RG93        257 CEISIEIPDKfIGSVIGKNGSRLTNIMnsTGAKIKISKKGELiPGTFDRKTKIIGtVAAVHAAHVLVLQCL 327  Plasmodium yoelii yoelii
EDV22924      273 TVIKIPVPDSiIGAILGKRGKVISDIQniSGAHIQVSQRGDYiPGTKDREVTVTGtNDAAHYADKLIKGYL 343  Trichoplax adhaerens
XP_002371355  277 CEISLQVPDQsIGAVIGRNGACVTEVInaTGARVQISQKGDLvPGTNDRKIVLSGtVGAVHSAHLLLLQRI 347  Toxoplasma gondii ME49
XP_005835975  203 VTYTVHVPDEvVPALLGKGGSVIREMMeaSGAQIRVSQKGEFvPGTNHRIITITGnQHSASYAHQLISSKI 273  Guillardia theta CCMP2712
PFX17360     1524 ATLELTVPDElIGAVLGKQGKTINEIMqySGAKIQVSQKGEFvPGTNNRKVVITGdFNCAQTAHFLITQRL 1594 Stylophora pistillata
PSC68326      729 ATITMAVPEDkVGVVIGKQGTVINQIKelLGVSIRISKKGEFlPGTYDRACSITGtPEAVEIAQRLIQQKL 799  Micractinium conductrix
XP_005839430  282 TVLKLSITDDaVGPLLGKGGCNLKEYIsvSGANIKVSQRGDTiPGTNNRYITIQGtAAAVQYAQLLVLQKA 352  Guillardia theta CCMP2712
Q9LZ82        234 TTVTIGVADEhIGLVLGRGGRNIMEITqmTGARIKISDRGDFmSGTTDRKVSITGpQRAIQQAETMIKQKV 304  thale cress
OON17276      514 CKKVIAVPESiIGLLLGPQGRSIVDLQasSGTVIQVSQKGVYaPGTQNRLVTITGpQLNVQWAANVIEQRV 584  Opisthorchis viverrini

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