1WOG,1T5G,1XFK,2A0M,1CEV,1GQ7


Conserved Protein Domain Family
Ureohydrolase
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cd09015: Ureohydrolase 
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Ureohydrolase superfamily includes arginase, formiminoglutamase, agmatinase and proclavaminate amidinohydrolase (PAH).
This family, also known as arginase-like amidino hydrolase family, includes Mn-dependent enzymes: arginase (Arg, EC 3.5.3.1), formimidoylglutamase (HutG, EC 3.5.3.8 ), agmatinase (SpeB, EC 3.5.3.11), guanidinobutyrase (Gbh, EC=3.5.3.7), proclavaminate amidinohydrolase (PAH, EC 3.5.3.22) and related proteins. These enzymes catalyze hydrolysis of amide bond. They are involved in control of cellular levels of arginine and ornithine (both involved in protein biosynthesis, and production of creatine, polyamines, proline and nitric acid), in histidine and arginine degradation, and in clavulanic acid biosynthesis.
Links
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Statistics
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PSSM-Id: 212511
Aligned: 6 rows
Threshold Bit Score: 335.938
Created: 17-Nov-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:Active site is composed of the metal binding (Mn), water and substrate binding (arginine) site.
  • Structure:1T5G: Rattus norvegicus arginase binds two Mn ions, a water molecule and arginine; contacts at 4A.
  • Comment:Inhibition by 1,6-diaminohexane arises from the displacement of the metal-bringing water.
  • Structure:1WOG: Deinococcus radiodurans agmatinase binds two Mn ions and inhibitor 1,6-diaminohexane; contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1WOG_A     32 AALGVPFDIalg---frpGARFAPRALREAslrsvppftgldgktrlqgvtfADAGDVilps---------------lep 93  Deinococcus radiod...
1T5G_A      4 EIIGAPFSKgcp----rgGVEKGPAALRKAglveklk---------eteynvRDHGDLafvdvpndspf--qivknprsv 68  Norway rat
1XFK_A     46 ALIGFECDAgvernkgrtGAKHAPSLIKQAlanlaw----------hhpipiYDLGNIrceg---------------del 100 Vibrio cholerae
2A0M_A     33 VIIGFPYDEgcvrnggraGAKKGPAAFRFFlqrlgsvnnle-lnvdashlklYDAGDItas-----------------tl 94  Trypanosoma cruzi
1CEV_A      5 SIIGVPMDLgqt----rrGVDMGPSAMRYAgvierle---------rlhydiEDLGDIpigkaerlheqgdsrlrnlkav 71  Bacillus caldovelox
1GQ7_A     33 VVIGAPYDGgts---yrpGARFGPQAIRSEsglihgvgidr-gpgtfdlincVDAGDInltp---------------fdm 93  Streptomyces clavu...

Feature 1                                #                             # # #              #   
1WOG_A     94 qLAHDRITEAARQVRGrcrvPVFLGGDHSVSYPLLRAfadv--------pdlHVVQLDAHLDFTdtrn---dtkwSNSSP 162 Deinococcus radiod...
1T5G_A     69 gKANEQLAAVVAETQKngtiSVVLGGDHSMAIGSISGharv-------hpdlAVIWVDAHTDINtpltt--ssgnLAGQP 139 Norway rat
1XFK_A    101 eQAQQECAQVIQQALPha-rAIVLGGGHEIAWATFQGlaqhflatgvkqpriGIINFDAHFDLRtfeselapvrpSSGTP 179 Vibrio cholerae
2A0M_A     95 eEAHEKLESKVFTVLArgafPFVIGGGNDQSAPNGRAmlraf------pgdvGVINVDSHLDVRpplq---dgrvHSGTP 165 Trypanosoma cruzi
1CEV_A     72 aEANEKLAAAVDQVVQrgrfPLVLGGDHSIAIGTLAGvakh-------yerlGVIWYDAHGDVNtaets--psgnIHGMP 142 Bacillus caldovelox
1GQ7_A     94 nIAIDTAQSHLSGLLKanaaFLMIGGDHSLTVAALRAvaeq-------hgplAVVHLDAHSDTNpafy---ggryHHGTP 163 Streptomyces clavu...

Feature 1                                                                                     
1WOG_A    163 FRRACealp----------------nlvhITTVGLRglrfdpeavaaararghTIIPMddvta-dlagVLAQlpr----- 220 Deinococcus radiod...
1T5G_A    140 VAFLLkelkgkfpdvpgfswvtpaisakdIVYIGLRdvdpgehy--iiktlgiKYFSMtevdklgigkVMEEtfsyllgr 217 Norway rat
1XFK_A    180 FNQIHhfcqqq-------------gwdfhYACLGVSrasntpalferadklgvWYVEDkafsplslkdHLTQlqhfi--d 244 Vibrio cholerae
2A0M_A    166 FRQLLeessf---------------sgkrFVEFACQgsqcgalhaqyvrdhqgHLMWLsevrkkgavaALEDafgl---- 226 Trypanosoma cruzi
1CEV_A    143 LAASLgfghpaltqig---gyspkikpehVVLIGVRsldegekk--firekgiKIYTMhevdrlgmtrVMEEtiayl-ke 216 Bacillus caldovelox
1GQ7_A    164 FRHGIdekli---------------dpaaMVQIGIRghnpkpdsldyarghgvRVVTAdefgelgvggTADLirek---v 225 Streptomyces clavu...

Feature 1              # #                                           #                        
1WOG_A    221 -gqNVYFSVDVDgfdpaVIPGTSSpepDGLTYAQGMKILAAAAann-tvVGLDLVELAPnld----ptgRSELLMARLVM 294 Deinococcus radiod...
1T5G_A    218 kkrPIHLSFDVDgldpvFTPATGTpvvGGLSYREGLYITEEIYktg-llSGLDIMEVNPtlgktpeevtRTVNTAVALTL 296 Norway rat
1XFK_A    245 dcdYLYLTIDLDvfpaaSAPGVSApaaRGVSLEALAPYFDRILhyknklMIADIAEYNPsfd----idqHTARLAARLCW 320 Vibrio cholerae
2A0M_A    227 tgkNTFFSFDVDslkssDMPGVSCpaaVGLSAQEAFDMCFLAGktp-tvMMMDMSELNPlve-----eyRSPRVAVYMFY 300 Trypanosoma cruzi
1CEV_A    217 rtdGVHLSLDLDgldpsDAPGVGTpviGGLTYRESHLAMEMLAeaq-iiTSAEFVEVNPild----ernKTASVAVALMG 291 Bacillus caldovelox
1GQ7_A    226 gqrPVYVSVDIDvvdpaFAPGTGTpapGGLLSREVLALLRCVGdl--kpVGFDVMEVSPlyd----hggITSILATEIGA 299 Streptomyces clavu...

Feature 1       
1WOG_A    295 ET 296 Deinococcus radiodurans
1T5G_A    297 SA 298 Norway rat
1XFK_A    321 DI 322 Vibrio cholerae
2A0M_A    301 HF 302 Trypanosoma cruzi
1CEV_A    292 SL 293 Bacillus caldovelox
1GQ7_A    300 EL 301 Streptomyces clavuligerus

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