Conserved Protein Domain Family
START_STARD15-like

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cd08914: START_STARD15-like 
Lipid-binding START domain of mammalian STARD15 and related proteins
This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD15/ACOT12 (also known as cytoplasmic acetyl-CoA hydrolase/CACH, THEAL, and MGC105114) and related domains. It belongs to the START domain family, and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD15/ACOT12 is a type II acetyl-CoA thioesterase; it catalyzes the hydrolysis of acyl-CoAs to free fatty acid and CoASH. Rat CACH hydrolyzes acetyl-CoA to acetate and CoA. In addition to having a START domain, most proteins in this subgroup have two tandem copies of the hotdog domain. Human STARD15/ACOT12 may have roles in cholesterol metabolism and in beta-oxidation.
Statistics
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PSSM-Id: 176922
View PSSM: cd08914
Aligned: 5 rows
Threshold Bit Score: 453.201
Threshold Setting Gi: 148233692
Created: 19-May-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative lipid binding site [chemical binding site]
Evidence:
  • Comment:based on the START domain of human ACOT11/STARD14 and related START domains with structure
  • Comment:The specific ligand of the ACOT11/STARD14 domain is unknown; pentaethylene glycol is a remnant of the crystallography process.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                    ##      #       ## #
Q8WYK0       311 FRRYRGAIARKRIRLGRKYVISHKEEVPLCIHWDISKQASLSDSNVEALKKLAAKrGWEVTSTveKIKIYTLEEhDVLSV 390 human
NP_570123    311 FRRYRGAIARKRIRLGRKYVISHKEEVPLCIHWDISKQASLSDSNVEALKKLAAKrGWEVTSTveKIKIYTLEEhDVLSV 390 human
XP_001369765 319 VRRYRGAIARKRIRLGRKYVVSHKEDIPLHVHWDENNQVYLSHSNVDALKALAAKsGWEVTSAggKVKMHTLEErDVLSV 398 gray short-tail...
NP_001086106 335 IRRFRGAIARRKIRVARKYILSTKQEKNISHPWDKGNQAYLSYNNIATLSVLAANnGWELSSTlpNIRICTHEEnDILSI 414 African clawed ...
DAA27185     313 FRRYRGALARKRIRLGRKYVISHKEEVPLCIYWDIGNQVSLSNGNVEALKSLAAKsGWEVTSAveKIKIYTLEEhDSLSV 392 cattle
Feature 1         #          #   #     #  ## ##                 # ####  #  # # #                 
Q8WYK0       391 WVEKHVGSPAHLAYRLLSDFTKRPLWDPHFVSCEVIDWVSEDDQLYHITCPILnDDKPKDLVVLVSRRKPLKDGNTYTVA 470 human
NP_570123    391 WVEKHVGSPAHLAYRLLSDFTKRPLWDPHFVSCEVIDWVSEDDQLYHITCPILnDDKPKDLVVLVSRRKPLKDGNTYTVA 470 human
XP_001369765 399 WVEKQVERSANLAFDLLSDFTKRPQWDPHFLTCEVIDWVSDNDTIYYITCPKVsNSKPIDLVVLVSRRKPAKDSNTYVVA 478 gray short-tail...
NP_001086106 415 KVEMQVKVQSQQAYFLLSDLGLRPNWDMHYLSCEVIETAGEDDKIFHITSPPVkQSKSRDFVILMSRRYTSKQGDPYVIA 494 African clawed ...
DAA27185     393 WVEKHVKRPAYLVYHLLSNFTKRPLWDPHYMSCEVIDRVSEDDQIYYITCPVVnNDKPKDLVVLVSRRRPLEDGHTYVVA 472 cattle
Feature 1        #                # #### #           # # ##### ### ### ###    #  ##  #       
Q8WYK0       471 VKSVILPSVPPSPQYIRSEIICAGFLIHAIdSNSCIVSYFNHMSASILPYFAGNLGGWSKSIEETAASCIQFLENP 546 human
NP_570123    471 VKSVILPSVPPSPQYIRSEIICAGFLIHAIdSNSCIVSYFNHMSASILPYFAGNLGGWSKSIEETAASCIQFLENP 546 human
XP_001369765 479 VKSVTLASIPPSPQYNRSEITCAGFLIRAVdSNSCTVSYLNQISSSILPYFAGNIGGWSRTIEEAAASCIQFIEEA 554 gray short-tailed o...
NP_001086106 495 MRSVTLASHPPTTEYLRSEVQCAGFLIHSLgKDLCQVCYLNQLTPGILPYVEENLTGWSNSIEETASSCIKFLETA 570 African clawed frog
DAA27185     473 VRSVILPSVPPSPQYVRSEIECAGFLIHATdSSSCTVSYFNQISASILPYFAGNLGGWSKSIEETAASCIQFIESA 548 cattle

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