Conserved Protein Domain Family
START_STARD7-like

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cd08911: START_STARD7-like 
Lipid-binding START domain of mammalian STARD7 and related proteins
This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD7 (also known as gestational trophoblastic tumor 1/GTT1). It belongs to the START domain family, and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. The gene encoding STARD7 is overexpressed in choriocarcinoma. STARD7 appears to be involved in the intracellular trafficking of phosphatidycholine (PtdCho) to mitochondria. STARD7 was shown to be surface active and to interact differentially with phospholipid monolayers, it showed a preference for phosphatidylserine, cholesterol, and phosphatidylglycerol.
Statistics
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PSSM-Id: 176920
View PSSM: cd08911
Aligned: 13 rows
Threshold Bit Score: 316.924
Threshold Setting Gi: 225718558
Created: 19-May-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative PtdCho
Feature 1:putative PtdCho binding site
Evidence:
  • Comment:phosphatidylcholine (PtdCho)
  • Comment:based on binding of human STARD2(PC-TP) to PtdCho

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                         ##      #               # #           #   #    
EAW71382     117 VQHHPPEPKAQTEGNEDSEGke------qrWEMVMDKKHFKLWRRPItg---tHLYQYRVFGTYTDVTPRQFFNVQLDt- 186 human
NP_001091310  78 AEDMKRMRPGADTIRGQTSTdte----dqgWELVVDKKDFKLWRRPIeg---tHLYQYRVFGSYRDVTPRQFFNVQLDt- 149 African clawed ...
XP_783781     96 DVDLIRILRSDPNPDLPQLSs---------WEKVMAKSEMMVWRRKMdh---dYLYEYKVFGTFTDCTAKSFFKVQTDl- 162 purple urchin
CAF99310     157 ALETVKNRDAASVLVGQLEPg---------WEVVMERRDFKVWRRPIpn---sHLYEYRVLGSYDDVTPRQFFNVQLDt- 223 Tetraodon nigro...
XP_001902099  26 ISDEMIMAEAKTSTNNDCED----------WEVVRNEGNSKVLRRLHag---tGLYEFRCSGSYDDITASDFVDAQMDl- 91  agent of lympha...
XP_967394    178 CIKNSRICQCQKPSDSIEKPklas---yddWKLFIEKNDLVVWRRLHs----sGNYEYKVYGSYADVSAEDFLNVQIDi- 249 red flour beetle
XP_001603678 168 GVKYCQCSKVKRASHKAQQDgi-------eWEPFIERKDMLVWRREEkd--crGLYSYKVYGSFDDVSAEDFLQVQIDi- 237 jewel wasp
EAT43243     140 IRYCCCPKNVTDMLSREDNEft-------aWEPYIEQKTMITWRKELk----pGLYAYKVFVEYPDITAEDFLHVQTDv- 207 yellow fever mo...
XP_002423136 140 LVIDSPSPNVDYCSCNGTKPvynkkvgtcpWVPFLERQDLLVWRKEQdh--npGMYEYKVYGFYEEIRADMFLQVQLDi- 216 human body louse
XP_625010    165 GIKYCTCYGEKFSATSNADPd--------gWRPYIERQDMLIWRREEpn--fgGLFSYKVYGTFSDVTAEDFLHTQIDl- 233 honey bee
XP_001943914 170 NQIECSYSSCDCPRCRNMSEe--------gWEPFTSGSYYNAWRKPNvdypgqNLYIYKVHGSFNDITALDFMQVQLDl- 240 pea aphid
NP_609644    170 LDLDVRNAPAGTVRIQAQDDq--------kWEPYFSKNEFSIWRRQEr----sSLYSYKVYARFDDITADDFLHVQTDl- 236 fruit fly
ACO15125     123 EYCTCSSPYFQLSDIDNEEAl--------dWLPFLEQKDILVWRKAHpk--ldGLFAYKMYGRFHDVSPREFLSAQLDis 192 Caligus clemensi
Feature 1          #     #                         # # #        # #                              
EAW71382     187 EYRKKWDALVIKLEVIERDVvs------gSEVLHWVTHFPYPMYSRDYVYVRRYSVDqenNMMVLVSRAVE--HPSVPES 258 human
NP_001091310 150 EYRKKWDALVIKLDVIERDGes------gSEIIHWVTHFPYPMYSRDYVYVRKYHVDqenNLMVLVSRAVQ--HPSIPES 221 African clawed ...
XP_783781    163 DYRNVWDKHVIETGVVDQDKet------gTEIVYWATQFPFPMNSRDYLYARRTQIFhrhRVMVIYSKATN--HPRKPET 234 purple urchin
CAF99310     224 EYRKKWDALVIKLEVVDRDPst------gSEIVHWATHFPYPMYSRDYVYVRRYDVDvenNLMILVSRAVQ--HPRVPET 295 Tetraodon nigro...
XP_001902099  92 AFRKKWDPNVEKLELVRKDDdt------dSELIHWVAKFPYPMYPREYVFVRRRYIDekdHCIVIANCAVAdsANIIPRC 165 agent of lympha...
XP_967394    250 DYRRQWDNTAVVLNIVEADPdph----shSDIIYWEMQWPTLFANRDYVFNRRYLVDykaKTLFLVSKSTK--HPSCPKQ 323 red flour beetle
XP_001603678 238 DYRKEWDATAKQLEIIDTDPeakessescSDVIYWEMVWPRMFANRDYVYQRRWLYDketGMVIIVSKGID--HPNAPNR 315 jewel wasp
EAT43243     208 EYRKKWDNTAVSLEVVDEDTtkg----snSSIIYWEMLWPKLFANRDYVYNRRYFVDrsrKVIVIVNKSVQ--HPKCPVK 281 yellow fever mo...
XP_002423136 217 EYRKTWDLTAVEIKLVDSDPys------nSNVLYWEMQWPKFFANRDYVFNRRYIIDpveKVMVITNHITE--HPSAPES 288 human body louse
XP_625010    234 EYRKKWDVTARELQVVDTDPslqksdnngIDIIYWETIWPRLFMNRDYVYQRRWVIDkekQLIIIISKVTE--HPHVPNK 311 honey bee
XP_001943914 241 QYRKEWDNMSVDLDIFDSEPlt------hSDLIYWEFRWPKWFQNRDYVFKRRYKIDedeKLMLIVCESIE--HPDYPEQ 312 pea aphid
NP_609644    237 DYRRQWDDTALRLELISEDPvpg----snSHLIYWEMQWPRLFANRDYVYCRRYIKDdnkKLIFICNRGAT--HNTYPAL 310 fruit fly
ACO15125     193 EFRKSWDTSTVECTALKETQgper--gsiDQVYYWEVAWPKFFANRDYVCQRSVRMSvdtGRIVVYTEAVQ--HPEYPRH 268 Caligus clemensi
Feature 1                             # # #                # # #              ###   #  ##  #     
EAW71382     259 p-------------EFVRVRSYESQMVIRPHk--sFDENGFDYLLTYSDNPQTVFPRYCVSWMVSSGMPDFLEKLHMATL 323 human
NP_001091310 222 p-------------DYVRVRNYQSQMVIQPHt--sFDENGFDYLLTYSDNPQTVFPRYCVNWMVSSGMPDFLDKLHMATV 286 African clawed ...
XP_783781    235 k-------------RYVRVTRFSSKMVIKPFt--sFDENGFDYMLTYHDDPKAPIPSSAVNWMATTGVPDFMHRVHNAAL 299 purple urchin
CAF99310     296 q-------------EFVRVHSYQSKMVIRPHk--sFDENGFDYLLTYSDNPQTVFPRYCVSWMVSSGMPDFLEKLHNAAL 360 Tetraodon nigro...
XP_001902099 166 e------------kKYVRVETYRSIMVVRAHk--tFDCKGFDYVLSYHDNPESNIPKYAYNWLVNYGGPYYLRQVHDAAK 231 agent of lympha...
XP_967394    324 q-------------TKYRIEDYWSYMVIRPYt--eLNKPGIEFSLTYFDNPGVNIPASVTTWVAMKAMPDFLERLREASR 388 red flour beetle
XP_001603678 316 p-------------DTHRVQTYWSYMVIKPYk--nFNEPGIEFGLTYFDDPGVNIPSAVTAWVAMSGFPDYLCRMRQAGK 380 jewel wasp
EAT43243     282 p-------------TNQRVNEYWSFMVIKPTsg-tFSKPGLSFILTYFDNPGLSIPKYITNWVAKKQMPDFLGQLHQATV 347 yellow fever mo...
XP_002423136 289 s-------------QKFRVKDYKCTMVIRPVt--tFDKPGVKFCMTYFDNPGLTIPGPIQTWVATSAMPDFLTRLRSASK 353 human body louse
XP_625010    312 pgiyrkktlkdfllTLNRVTTYWSYMVIRPYt--eLHQPGIEFGLTYFDDPGVNVPSTITSWVTMTGLPDFLLRMRHASK 389 honey bee
XP_001943914 313 n-------------NKWRVKDYWSYIVIKPHd--aFDKPGVEFSITYFDDPGVTVSNYLTSWYQCKGLPSFLNDQRLAAL 377 pea aphid
NP_609644    311 s-------------GKVRVTDYWSLMVIKPFr--gFHEPGLHFVLTYFDDPGIPIPQNIKSWVTQKQMPEFLTKMYVATK 375 fruit fly
ACO15125     269 n-------------KEFRVENYFSILTIQSVkegdLDAKGLEFTLTAFENLGLSLPTSITTWVAMRGLPQYIQDMRRACL 335 Caligus clemensi
Feature 1          
EAW71382     324 KA 325 human
NP_001091310 287 QA 288 African clawed frog
XP_783781    300 AL 301 purple urchin
CAF99310     361 RA 362 Tetraodon nigroviridis
XP_001902099 232 KL 233 agent of lymphatic filariasis
XP_967394    389 KY 390 red flour beetle
XP_001603678 381 DY 382 jewel wasp
EAT43243     348 NY 349 yellow fever mosquito
XP_002423136 354 RY 355 human body louse
XP_625010    390 NY 391 honey bee
XP_001943914 378 EL 379 pea aphid
NP_609644    376 NY 377 fruit fly
ACO15125     336 QK 337 Caligus clemensi

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