1EM2


Conserved Protein Domain Family
START_STARD3-like

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cd08906: START_STARD3-like 
Click on image for an interactive view with Cn3D
Cholesterol-binding START domain of mammalian STARD3 and related proteins
This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD3 (also known as metastatic lymph node 64/MLN64) and related proteins. It belongs to the START domain family, and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD3 has a high affinity for cholesterol. It may function in trafficking endosomal cholesterol to a cytosolic acceptor or membrane. In addition to having a cytoplasmic START cholesterol-binding domain, STARD3 also contains an N-terminal MENTAL cholesterol-binding and protein-protein interaction domain. The MENTAL domain contains transmembrane helices and anchors MLN64 to endosome membranes. The gene encoding STARD3 is overexpressed in about 25% of breast cancers.
Statistics
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PSSM-Id: 176915
View PSSM: cd08906
Aligned: 5 rows
Threshold Bit Score: 365.339
Threshold Setting Gi: 198428839
Created: 19-May-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative lipid
Conserved site includes 44 residues -Click on image for an interactive view with Cn3D
Feature 1:putative lipid binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                     ##       #           # #           #   #      #  ##
1EM2_A        18 AQEREYIRQGKEATAVVDQILAQEenWKFEKNneyGDTVYTIEVPfHGKTFILKTFLPC-PAELVYQEVILQPERXVLWN 96  human
XP_001232168 232 AQEKEYVRQGKEAMEVVDQILAQEenWKFEKNndfGDVVYTFEIPfHGKTFILKAFLQC-SAETVYQEVILQPEKMILWN 310 chicken
Q90ZB9        82 PQEKALVRQGKEAMAVVEQILAQEenWKFEKNndvGDSVYTLEIPfHGKTFILKAFMQC-PAELVYQEVILQPEKMAQWN 160 brook trout
NP_001079965 231 PQEREYVRQGKEALLVIEQILSQEanWKFEKSsdaGDVVYSLEVPfHGKTFILKTLMQC-PAETVYQEVILQPEKMVLWN 309 African clawed ...
XP_002130557 305 EADVAIVNEGKNGLDQLWELYQNNtiWKTEKVlsnGDTVFSYDNKeFGKTFKIVANIPAvTPSVLFNEIIRKPEEMPQWN 384 Ciona intestinalis
Feature 1         ##                 # ####    #  # # #              #                 # #### #  
1EM2_A        97 KTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRIERRrDRYLSSGIATSHs-aKPPThKYVRGENGPGGXIV 175 human
XP_001232168 311 RTVAACQVLQRVEDNTIVSYDVAAGAAGGVVSPRDFVNVRRIERRrDRYISSGMSTTHs-lKPPLsKYVRGENGPGGFIV 389 chicken
Q90ZB9       161 KTVSGCQILQRVDDNTLVSYDIASGAAGGVVSARDFVNVRRVERKrDCYVSAGMATDHd-gKPPHsRYVRGENGPGGFVV 239 brook trout
NP_001079965 310 RTVALCQVLQRIDDNTLVSYDVAAGAAGGMVSPRDFVNVRRIERRkDRYISAGISTTHi-sRPPLtKYVRGENGPGGFLV 388 African clawed ...
XP_002130557 385 KTVSDVKVLGKVGEQTFITLEVSAPAAMGLISSREFVTVRRVDKFgDDYVSAGISTNAcehMVPKsNFVRGVNGPTGFVV 464 Ciona intestinalis
Feature 1                   # # # # # #      # ### ###  ##  #       
1EM2_A       176 LKSAsnPRVCTFVWILNTDLKGRLPRYLIHQSLAATXFEFAFHLRQRISEL 226 human
XP_001232168 390 LKCPsnPRVCTFIWILNTDLKGRLPRYLIHQSLAATMFEFAFHLRQRVAEL 440 chicken
Q90ZB9       240 LKSSsnPSVCTFIWVLNTDLKGRLPRYLIHQSLAATMFEFMAHLRQRIRDL 290 brook trout
NP_001079965 389 LKYPknPSMCTFIWVLNTDLKGRLPRSLIHQSLGATMFEFCSHLRKRIRDV 439 African clawed frog
XP_002130557 465 GPGAdgPYSTKFIWILNTNLMGNLSRSLVNRNLTSTMINFVSAMKERLKVL 515 Ciona intestinalis

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