Conserved Protein Domain Family
START_STARD1-like

?
cd08905: START_STARD1-like 
Cholesterol-binding START domain of mammalian STARD1 and related proteins
This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD1 (also known as StAR) and related proteins. It belongs to the START domain family, and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD1 has a high affinity for cholesterol. It can reduce macrophage lipid content and inflammatory status. It plays an essential role in steroidogenic tissues: transferring the steroid precursor, cholesterol, from the outer to the inner mitochondrial membrane, across the aqueous space. Mutations in the gene encoding STARD1/StAR can cause lipid congenital adrenal hyperplasia (CAH), an autosomal recessive disorder characterized by a steroid synthesis deficiency and an accumulation of cholesterol in the adrenal glands and the gonads.
Statistics
?
PSSM-Id: 176914
View PSSM: cd08905
Aligned: 7 rows
Threshold Bit Score: 374.172
Threshold Setting Gi: 226372374
Created: 19-May-2010
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
 
putative lipid
Feature 1:putative lipid binding site [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                  ##       #           # #          #   #      #  ## 
P49675     70 DQELAYLQQGEEAMQKALGILSNqegWKKESQqdngDKVMSKVVPdVGKVFRLEVVVDQPMERLYEELVerMEAMGEWNP 149 human
AAG28595   74 DVEMSYIKQGEEALKKSLNILGDqdgWKTEIVmengDKVLSKVLPdIGKVFKLEAVVEKPLDNVYGELVdnMEKMGEWNP 153 African clawed frog
Q9DEB4     69 EAEVSYVKQGEEALQKSISILGDqdgWTTEIIaangDKVLSKVLPdVGKVFKLEVLLDQRSDNLYVELVgnMEQMGDWNP 148 rainbow trout
1711558    69 DQELSYIQQGEVAMQKALGILNNqegWKKESQqengDEVLSKMVPdVGKVFRLEVVVDQPMDRLYEELVdrMEAMGEWNP 148 house mouse
AAS64369   70 EAEMAYVKQGQEALHKSLSILQDtsgWKTEMEaingDKVVSKMVPdIGKVFKLEVVMDKPTDLLYSELFdrVEQMGEWNP 149 South American fre...
ACO51812   78 SRDMFYLNQIKETLHKAKSMLQQe-gWQTEQKn--eDWILSKSFPkIGKVFRAEAVIDSPPEHIYTQLFekLEHIDQWNP 154 bullfrog
AAG28594   70 EMEMSYIKQGEEALQKSLSILGDqegWKTETVadngDKVLSKVLPdVGKVFRLEVVVDQPLDAVYSELVdnMEQMGDWNP 149 chicken
Feature 1     ##                 # ####    #  # # #              #                # #### #    
P49675    150 NVKEIKVLQKIGKDTFITHELAAEAAGNLVGPRDFVSVRCAKRRGSTCVLAGMATDFgnMPEQkGVIRAEHGPTCMVLHP 229 human
AAG28595  154 NVKEVKILQKIGKDTVITHEKAAETPGNIVGARDFVSVRCSKRRGSTCILAGMSTRFggMPEQkGFVRGENGPTCMVLRP 233 African clawed frog
Q9DEB4    149 NVKEVKILQKIGQETMVTHEVSGPTPGNVVGPRDFVSVRCAKRRGSTCFLAGMSTQHptMPEQrGVVRAENGPTCIVMRP 228 rainbow trout
1711558   149 NVKEIKVLQRIGKDTVITHELAAAAAGNLVGPRDFVSVRCTKRRGSTCVLAGMATHFgeMPEQsGVIRAEHGPTCMVLHP 228 house mouse
AAS64369  150 NVKQVKILKRINKDTMVTYEASAETAGNVISPRDFVSVRYAKRRGSTCFLAGMAMHCnlMPQQnGFIRGENGPSCIVLCP 229 South American fre...
ACO51812  155 NISKVQILQRIGKNTLLTREVTAQNLAHMVSQRDFVNVQHCCRSGSSLYLIGTEAHSnlMPPQkEMIRAKAKLTCIILRP 234 bullfrog
AAG28594  150 SVKEVKILQRVGKDTLITHETAAAPPGNIVGPRDFVSVRCSRRRGSTCVLAGMSTTHgaMPEQqGFIRAENGPTCMVLRP 229 chicken
Feature 1              # # # # # #      # ### ###  ##  #       
P49675    230 LAgsPSKTKLTWLLSIDLKGWLPKSIINQVLSQTQVDFANHLRKRLESH 278 human
AAG28595  234 LAedVSKTKLTWLLSIDLKGWLPKSIINQVLSQTQVDFAKHLRSRMASS 282 African clawed frog
Q9DEB4    229 SAddPNKTKFTWLLSIDLKGWIPKTIINKVLSQTQVDFANHLRQRMADN 277 rainbow trout
1711558   229 LAgsPSKTKLTWLLSIDLKGWLPKTIINQVLSQTQIEFANHLRKRLEAS 277 house mouse
AAS64369  230 SAedPNKTTLTWLLSIDLKGWLPKSLINKALCQTQADFAQCLRQHMNSK 278 South American freshwater stingray
ACO51812  235 VEgdRRKTHFTWLLSLDLKGWIPQSITERVLSQSQADFISHLRRHLSSL 283 bullfrog
AAG28594  230 LAgsPSQTKLTWLLSIDLKGWLPKTIINQVLSQTQVDFAKHLRQRMARA 278 chicken

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap