Conserved Protein Domain Family
SRPBCC_CalC_Aha1-like_8

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cd08901: SRPBCC_CalC_Aha1-like_8 
Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins
SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.
Statistics
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PSSM-Id: 176910
View PSSM: cd08901
Aligned: 21 rows
Threshold Bit Score: 167.837
Threshold Setting Gi: 73663659
Created: 31-Jul-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         # # #        ### ##    #        #      # # # #        # ## #  #     # ##       
YP_001314475   6 RARAEMLIRKPVREVFEAFVDPEITAKFWFT-GGSGRLEKGKSVTWEWAMYGv--TVPVTVKALEEnRRILIDWlgdl-- 80  Sinorhizobium m...
YP_002881085 192 VMRTSILVRRPARDVFGLFTDPGLTTLVWFT-HSTGPVQPGARLTWTWEMFDl--HVPVRVHEVVPdRRILLEWgdd--- 265 Beutenbergia ca...
EDL65532      24 SLTTAMKIQRPASEVFQALINPEQMSNYWFS-SGSGRIEEGKTITWRYDEYNa--EGIVNILEVVDpAKIVFTWgdp--- 97  Bacillus sp. SG-1
YP_615512      4 KFRVAARIAKPIDEVFEAVADPAKLSAYFTTgGAKGRLETGATVTWDFHDYPg--AFPVYVIEVVKdERIVLEWqasege 81  Sphingopyxis al...
YP_302440      2 DIITKMQVDVPRETVFEAFVDPEKIGGFWFS-SSSERWEQGKTITLRYEEYDa--ELNINIERVEDnQLIAFTWg----- 73  Staphylococcus ...
BAB98119      13 QVSTFGYISRCPVQVYEAIADPRQLERYFATgGVSGRLETGSTVYWDFVDFPg--AFPVQVVSATQaEHIELRWgqa--- 87  Corynebacterium...
YP_002772235  23 NNLTKFQINRPAQEVFEAFVDPEKIGNFWFS-SSSARWEEGKSIMLFYDIYNa--EVGITVHEIEVnKRIVFQWag---- 95  Brevibacillus b...
ZP_01015870    1 MAKAATMIAAPPLVCYEAFATPDRMTEFWFP-RVSGPIEKGVTLTWYVGTAPdahPITVEVVEAMPgERIDIRWgdg--- 76  Rhodobacterales...
ZP_01722836    5 NVTTKLKIKQPAHKVFEAIISPTEIGHYWFS-SSSERWAEGKRITLRYEEYSa--EGIISVLEIVTnKKIVFSWgeeh-- 79  Bacillus sp. B1...
YP_863602      5 EIKAALQIRKTAQEVFEAIVDPEKMSHYFIS-ESTGKMEEGISVTWKFPEFEd-mEVPVRVIKTTApKLIIFEWegak-- 80  Gramella forset...
Feature 1                        ## # #           # # # #         ######### ###  #          
YP_001314475  81 ------------dssTEVEWVFTPrp-dgSTFVSITNWGFNGddverieHAVGSTEGFTLVLAGLKAFLEHGVQL 142 Sinorhizobium medica...
YP_002881085 266 ------------gatTHVEWTFSAdd-dgATRVEIVERGFVGtademvaAALDSTIGFTQVLTAAKAYLEHGVRV 327 Beutenbergia caverna...
EDL65532      98 ------------eqpTTVTIKLEEqe-kdSTVIRVTESGFGEnpd--leRMLGQKEGWVYMLTCLKAYTENGVNS 157 Bacillus sp. SG-1
YP_615512     82 apnveggeladadyrTRVTMSFKAld-dgRTLVEISEEGWREnqa-alsASYGNCQGWAQMLCALKAWIEHGINL 154 Sphingopyxis alasken...
YP_302440     74 --------------aHPITIQFEEse--aGTVVTTTEKDFDTqd---vkQLLGQKEGWVYMLSCLKVYLEHGVTI 129 Staphylococcus sapro...
BAB98119      88 ------------nelRSVNFEFEPfrnftRTKLTITEGSWPLtpa-gaqEALGSQMGWTGMLSALKAWLEYGVNL 149 Corynebacterium glut...
YP_002772235  96 -------------eeNTVTITLNEld-kaTTIIEVNEEGFQEndpallqKMIDNKEGWVYVLSCLKGYLEHGINT 156 Brevibacillus brevis...
ZP_01015870   77 ------------tqmTDVSWTFIEkg--pMTEVKVTETGFEGdeaaqaaQAIDSTGGFSQVLIAAKALIEHDVSI 137 Rhodobacterales bact...
ZP_01722836   80 ------------gevTIVTMTLEEyq--gETIMEVVESGLNAhdpeivmKMMGQKEGWIYTLTCLKGYLENGINT 140 Bacillus sp. B14905
YP_863602     81 ------------delLQVKITLEEkp-nnSTLVKITEGKMQAtee-givWYGRNTEGWANFLACLKAYLEFGINL 141 Gramella forsetii KT...

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