Conserved Protein Domain Family
SRPBCC_CalC_Aha1-like_7

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cd08900: SRPBCC_CalC_Aha1-like_7 
Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins
SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.
Statistics
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PSSM-Id: 176909
View PSSM: cd08900
Aligned: 21 rows
Threshold Bit Score: 155.515
Threshold Setting Gi: 89070901
Created: 31-Jul-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         # # #        ### ##    #               #       # # # #         # ## #  #     # 
Q98FH6        10 TFIIERLYPAPPSKVFFALGNaDAKRRWFtdpd-npmPGRFEMDFRVGGKEVNAGgpkd-gpihVYTATYQDIVPdQRIV 87  Mesorhizobium loti
ZP_02381523   10 TFTLNRVWAARPDRVFAAWSDpDLKAQWFtgpaerwtLLRRSMDFRVGGAEVLEGrfdesgmetLFEARYHVIEPaRRLV 89  Burkholderia ub...
YP_001314002  10 TFTLKRIWAAPPHRVFDAWSDpQLKAQWFtgpperwtLLRRSMDFRVGGQEVLEGrfhesgtvtLFEARYHAIEPaRRLV 89  Sinorhizobium m...
YP_768345     10 TLVIERHLKAPISRVFRAWSTpESKRQWFachg-ewvPLDYGLDFRPGGTERNYVadtd-gllhAYDAHYIDIVPdARII 87  Rhizobium legum...
YP_675402     10 TFVIERELPGNAAHAFRFWSDaKLKALWNschp-dwtVLEDIFDFRPGGSETKRWrtae-gheqTFAAHFFEIVPeRRII 87  Mesorhizobium s...
ZP_05083434    9 TIIIREKLEASAEEVFAAWEDpNARTVWGvpsd-deaIAFLENDFRVGGLDVHQCgqng-dlrfRVETRYHDIRRpDLLL 86  Pseudovibrio sp...
ZP_01011371    7 RFTLERGIAALPAAVWAAFFDpKARAIWSppsp-devFEVLEHDPRDGGTGLHRCgpks-dptyIVETRYHKLDEpAAVS 84  Rhodobacterales...
ZP_01744238    6 TMTLERQIACAPDRLFRLLTTkDGREAWGapsd-tavVIIDAFDCRPGGHEKTRCgpke-apefETHTAFHRVDP-ECLV 82  Sagittula stell...
ZP_01749414    7 SFDLHRTLPLSTERLWQVLTDaKEREKWAgpda-atmLETDFADLRVGGQDRHRFgpkd-apefLVDTRWYDLTKpERAV 84  Roseobacter sp....
NP_357588     23 TLSFEREIAVPLSALWQVWLSpAARAVWAspsp-svtVEFLEADSRLGGREVSLCkvag-qpdiRCECGWLELQPtRRSV 100 Agrobacterium t...
Feature 1        ##             ## # #          # # # #         ######### ###  #      
Q98FH6        88 YSYdmlfGETRISVSLATIQLFAeg-eGTRLVLTEQGAFLDGh---dTPSTREHGTGVLLDLLDAFLDK 152 Mesorhizobium loti
ZP_02381523   90 YSYdlhhSGRFHSVTLSSLELEPqg-dGTRVSYTEQIVFLDGk---dGTADRRQGSALMYDAIENVLRS 154 Burkholderia ubonensis Bu
YP_001314002  90 YTYdlhhSGRFHSVTLSSLQLESea-gGTRVSYTEQIVFLNGk---dGTSDRHNGTEIQFDMIEANLRS 154 Sinorhizobium medicae WSM419
YP_768345     88 YAYemklGESRISASLTTVAFEAap-gGTKMVFTEQVVFLDGy---aDNGARLQGTEIGLDNLELFLER 152 Rhizobium leguminosarum bv...
YP_675402     88 YAYhmgfRGQALSASLATVEFAPagggRTRMTFTEQIAFLGEanarqRIAGTEQGFDRLIEAIAKDLTE 156 Mesorhizobium sp. BNC1
ZP_05083434   87 FTErvstGDMLLSASLITVTMNGeg-sTTELSVTVQVISMVGt---dMIEATRGGWQASLVRLAGYLER 151 Pseudovibrio sp. JE062
ZP_01011371   85 FTEivrkGDTPLAASQVSVVFAAte-aGTRLTLDVYTTSFVGd---gMLAGTKGGWTTSIANLIHHIEN 149 Rhodobacterales bacterium ...
ZP_01744238   83 STEsliiGGDLLSASLCTHDIAArd-gGTHLTVTLQIASFAGp---eLFEDYTQGWSGALDTLVRVATA 147 Sagittula stellata E-37
ZP_01749414   85 FTEtlifGGEAVSTSLVTYLLLGdg-nETKLSITVAVSSFSGp---eALDEIQQGWAGGVDNLAAYAKA 149 Roseobacter sp. CCS2
NP_357588    101 NYEvvssGGVTQSAALVTADFQSae-eRSRLTVTVQLSSLARd----MRDGYHEGFGAGLNNLASVAGR 164 Agrobacterium tumefaciens ...

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