2NN5,2K5G


Conserved Protein Domain Family
SRPBCC_CalC_Aha1-like_6

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cd08899: SRPBCC_CalC_Aha1-like_6 
Click on image for an interactive view with Cn3D
Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins
SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.
Statistics
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PSSM-Id: 176908
View PSSM: cd08899
Aligned: 66 rows
Threshold Bit Score: 111.23
Threshold Setting Gi: 73663479
Created: 31-Jul-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 43 residues -Click on image for an interactive view with Cn3D
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                     # # #        ### ##    #          #       # # # #         # ## #  #
2NN5_A        26 KDTFRLENQt-iYFGTERAISASPQTIWRYLTEtDKLKQWfp---elEIGELGVnGFWRFILpd------fEETXPFTDY 95  Enterococcus fa...
Q8ET51         4 YGTLHETNGn-yALRFERFFSLNPEDVFDVITNsDYFTQWypf--atGEMDLRLgGEINFDDge-----gtTYNAIITEM 75  Oceanobacillus ...
YP_001359938   4 LGDAVLHGGdraTLRLARDYDHPVAAVWTALTVpALTRLWwa----dLRTDLQVgGEFSLEWltgppgeleWWPGEITAM 79  Kineococcus rad...
YP_960407      9 DGQIRFETGr-vLVHLERLLDHPPEAVWNMLTDsVHLANWla----aGSLEAREgGRVQLDFgns----gmPIDCTITAC 79  Marinobacter aq...
YP_001623236   6 NGSIERTAEg-gLVRFDRLLAFSIEDVWAAITEpARLSDWwppftaeITVDLRVgGKLVFVWpdt---dfpTFEFTITGL 81  Renibacterium s...
Q723Q7         2 NESICKRDNggaVVNFELEINATKAEVFALLTTnAGLAKWfn---elEVGELGAdGYLLFVMtp-----eeKITMPIRAF 73  Listeria monocy...
ZP_01722772    6 LATIEEHSNh-hVATFKRTLPHSIDVVWAAITHnDKLQKWms---nlEIIDLRKnGKMHFNMndg---tdaYETIGITDY 78  Bacillus sp. B1...
ZP_04151414   22 MLALIEKIDneyVAQFNRSLNHAVEQVWAVLTEnDKLARWmp---nlYVENLRKgGIIKFDMmdg---sgnFIDINILDC 95  Bacillus pseudo...
Q63B15         2 LAVIDKQDNe-yVVQFDRHFSYSIEEVWSVLTEnSKLKKWms---nlQIESLKTnGVIKFDMmd-----gsFINIDIIEC 72  Bacillus cereus...
YP_302260      1 MEAVYSKDEqgaYQTLKIIIEQDVATVFKLLSTtEGIQQWfp---qlSFEDRQVgGKMKFQMdg-----qdDEEMEITAF 72  Staphylococcus ...
Feature 1             # ##         ## # #              # # # #       ######### ###  #            
2NN5_A        96 AEEKYLGVTWDt-----GIIYFDLKEqa----phQTLLVFSESLPENft--tPRHKDIAGWSIVLNRLKQVVETpd---- 160 Enterococcus fa...
Q8ET51        76 EKPYLFSFREVd-----DLINISLLEed-----eGCRMIFTHTFNDDs----WAVPTAAGWHRCLDVLGQIVNGnp---- 137 Oceanobacillus ...
YP_001359938  80 DAPRLLEHTNSe----hGLLRWELEPldagalraRTRLRLTNDLEGEd---aWVPMSLAAWHLHLDQLATALDGg----- 147 Kineococcus rad...
YP_960407     80 RPHRLLSYSWSsgdapeRPLTWEILReg-----vCTRLCLTLSLPDDe----VVPIACAGWDAHLEMLMAALEGisihfp 150 Marinobacter aq...
YP_001623236  82 EVPRLLEHTHAsp---gAWMRWELEStp-----eGTRLLATYFIPNQnvemaIERGDIVGLHHSLDRLEPALSGhp---- 149 Renibacterium s...
Q723Q7        74 ETNQKLAFEWDq-----DEVDFELNEit----anKTRLTFREQLTTIt---eHSPRDISGWHICLKKLQASAEGki---- 137 Listeria monocy...
ZP_01722772   79 AENETLEFDWGt-----DTVRFELSStd-----eGTLLLLVKTLQALt---eHTPKDLAGWHICLDLLTDLLDGqer--- 142 Bacillus sp. B1...
ZP_04151414   96 QVNSVLEFTWGe-----DRVRFEVHKnp-----dGCLLILKEFIHEIn---eHTPKDLSGWHICLEIFSAVLDGh----- 157 Bacillus pseudo...
Q63B15        73 QQNSVLEFTWDk-----DRVRFEIHKee-----nGSLLLLKEYIHELt---dHTPKDIAGWHICLDLFSAILEGee---- 135 Bacillus cereus...
YP_302260     73 EENETIGYTWDi-----GTVRFDLHDag-----kETVLIFDECLPFAf---pHIILDFAGWQFQMENIKQVAETgss--- 136 Staphylococcus ...
Feature 1                          
2NN5_A       161 aaPEKIDFPQIENHYLEK 178 Enterococcus faecalis
Q8ET51       138 -vKWDDNAAKLREIYSEA 154 Oceanobacillus iheyensis
YP_001359938 148 -gVDWSAWASATNLRMRE 164 Kineococcus radiotolerans SRS30216
YP_960407    151 aaRFRAARSHFEKLLKEK 168 Marinobacter aquaeolei VT8
YP_001623236 150 apWDNDAFDEIRAGYAKV 167 Renibacterium salmoninarum ATCC 33209
Q723Q7       138 ydFNKTEFETLFAKYQKE 155 Listeria monocytogenes str. 4b F2365
ZP_01722772  143 ltFPMESWQQRFHDYKDL 160 Bacillus sp. B14905
ZP_04151414  158 --DMDFPKDEWEKWYKRY 173 Bacillus pseudomycoides DSM 12442
Q63B15       136 keFSKDKWQQWFEKYKDK 153 Bacillus cereus E33L
YP_302260    137 idQQALDFDSKKQEIAEK 154 Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

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