Conserved Protein Domain Family
SRPBCC_CalC_Aha1-like_5

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cd08898: SRPBCC_CalC_Aha1-like_5 
Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins
SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.
Statistics
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PSSM-Id: 176907
View PSSM: cd08898
Aligned: 26 rows
Threshold Bit Score: 132.819
Threshold Setting Gi: 21222461
Created: 31-Jul-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          # # #        ### ##    #             #        # # # #       # ## #  #     # ##
YP_841648      6 DRIERSILLAAPIERVWHALAdaDTFGSWFGvkfdgvtFAPGQRAV--GSITYPGye---ylKFDVEVERMEPpRLLSWR 80  Ralstonia eutro...
ZP_03268718    6 DRIEKQILLKAPRSRVWRALSdaEEFGKWFGvnltgkqFVAGQSTQ--GHITYPGye---hlMMNVVVERVEPeHHLSWR 80  Burkholderia sp...
ZP_05007840    5 DRIEKEIVIAAPPERVWAVLTepEHVGAWFGqg---epTPVELRAG--GTMLLDHge---ygQFPTTVVEVEPpHRFSYR 76  Streptomyces cl...
YP_002883872  13 FTVSRTVRIDAPLSTVWTALTapEHLAGWFGdr---aeFPDGVHVGaeGTFGWPDh-----gDFPVRVVEFAPeERFAFT 84  Beutenbergia ca...
ZP_01129078   16 FTVRRTITIKASADTVWAAISepEHLSRWFPqta--tfDTVAEGAQ--GSFTFEGy-----gTFPVQIEELDApNVIAYR 86  marine actinoba...
ZP_00994779    4 GTLERSVHVEASPEVVFEVVSqpEHIREWWSdda--slDDLAPGAV--GELVWGDra----qVESFTVVEVDPpRRFSFR 75  Janibacter sp. ...
YP_001535167   4 GTIEREIYVEASPEIVFEVVSspEHLRQWWPdd---arYDPRPGSA--GEIVFGDrda-ggtVVPFTVVSARPpRTFSFR 77  Salinispora are...
YP_527311      3 DTINRDITINASKEHIYDAISnpEHVTKWFPt------TIEGDYSV--GSQPIFGfge--hgKNQIYVVAARPhEYFAYR 72  Saccharophagus ...
YP_704164      5 SSITRTVVVNAPRSAVWAAITdpDKISQWFGq-----rTSLDLSVG--GKAAFTWde---hgTARAVVTEVDEpNTFGFR 74  Rhodococcus sp....
YP_001702751   4 ERIERELHIEATPEIVFSVISrpEHMKQWWPde---aeFARAPGAT--GEISFNGdeagqihVFGLTLVEVDPpWRFSFR 78  Mycobacterium a...
Feature 1                          ## # #          # # # #                  ######### ###  #     
YP_841648     81 WHPapmergrDYSAEPPTLVVFELKEae-gGTLLTVVESGFDQip--peRRMe------AFRMNSGGWDGQMENIRKHVS 151 Ralstonia eutro...
ZP_03268718   81 WHPaaidstiDYTPEPTTLVEFDLTEve-sGTLLRVVESGFDQlp--agRREq------AFRLNEGGWGQQMANIERYVG 151 Burkholderia sp...
ZP_05007840   77 WASahp--geQAVPGNSTLVEFTLTPeg-eGTRLRVTESGFTAleipeeRREt-----aSYESHDGGWAGQVENIRDYTE 148 Streptomyces cl...
YP_002883872  85 WGTpg----ePIRADNSTTAHFTLDPdg-dTTVVTVLETGFEDlgddarRRA-------AMEDNRSGWTEELDQLVAYVA 152 Beutenbergia ca...
ZP_01129078   87 WGGptddptkPIDPNRSTVFRFTLEAie-dGTQLTVVETGFNFgd---dPTA-------NMEQHRGGWDSELDELVAYLE 155 marine actinoba...
ZP_00994779   76 WVTsa---geAATEGNSLLVTFDLEPsa-tGTTLRLTETGFRE------RGWevavleqAYRDHENGWDAFLPRLVAHAG 145 Janibacter sp. ...
YP_001535167  78 WTHpa---deAAAEGNSLLVTFDLTPsg-gGTLLRVTEAGFREl----gWEAavl--krQYQKHVAGWDFHLSRLVPYIA 147 Salinispora are...
YP_527311     73 WVPganhylgDVLAVPNTLVEFKITEladdTCKVTLTESGFSSl-----PTElm---eaAFNQNSGGWDFMLSRLESLFD 144 Saccharophagus ...
YP_704164     75 WAAdm---daDPVIGNSTLVRFTLSEha-sGTELTVVETGFDTl-----DRDvad-qkrAREGNVQGWHAELDELVAYLH 144 Rhodococcus sp....
YP_001702751  79 WCYpe---ghTANPENSLLVTFDLTQeg-tGTRVRMTEIGFRDq----gRTEaei--aeQYAAHEEGWARHLPRLAPCVD 148 Mycobacterium a...
Feature 1         
YP_841648    152 G 152 Ralstonia eutropha H16
ZP_03268718  152 A 152 Burkholderia sp. H160
ZP_05007840  149 K 149 Streptomyces clavuligerus ATCC 27064
YP_002883872 153 T 153 Beutenbergia cavernae DSM 12333
ZP_01129078  156 G 156 marine actinobacterium PHSC20C1
ZP_00994779  146 T 146 Janibacter sp. HTCC2649
YP_001535167 148 G 148 Salinispora arenicola CNS-205
YP_527311    145 A 145 Saccharophagus degradans 2-40
YP_704164    145 G 145 Rhodococcus sp. RHA1
YP_001702751 149 A 149 Mycobacterium abscessus

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