Conserved Protein Domain Family
SRPBCC_CalC_Aha1-like_4

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cd08897: SRPBCC_CalC_Aha1-like_4 
Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins
SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.
Statistics
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PSSM-Id: 176906
View PSSM: cd08897
Aligned: 23 rows
Threshold Bit Score: 219.086
Threshold Setting Gi: 162448161
Created: 31-Jul-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         # # #           ### ##    #     #                # # # #         # ## #  #     
YP_001194059   1 MITVQNTINA---SINKVWDFWTLPEHITKWSFASPDWHTPYAENDIKQGGKFKSTMAAKDGSMSFDFEGEYTFVEPnKT 77  Flavobacterium ...
YP_002884730   5 VVTISALVDA---PIDTVWKLWTDPDHIKQWNHASDDWHTTEAENDLRIDGKFRSRMEAKDQSMAFDFEGVYEEVEVnEL 81  Exiguobacterium...
YP_863496      6 TINVETSIDK---SVEKVWEFWTKPEHITKWNHASEDWLCPSAENDLKEDGKFVYRMEAKDGSFGFDFSGVYKEVKPkKK 82  Gramella forset...
ZP_03970003    9 QITVEATIDA---PVEIVWKAWNTPADIMQWNAADPSWHCPSSKNDLRVNGKFSNRMEARDGSFGFDFEGTYQQVDLhEK 85  Sphingobacteriu...
ZP_03851624    4 KITVSATINA---DAQKVWDYYTNPEHITRWNFADPSWQCPFASNDMKVGGKYAARMEAKDGSFGFDFEAVYNEINEgKN 80  Chryseobacteriu...
NP_350271     11 KITIETTVNA---PIDMVWEAWTEPEHIKSWNHASDDWHTTEAKNDLRVGGRFVSKMEAKDGSFGFDFGGTYNKVRLyEF 87  Clostridium ace...
YP_003013269  17 SISLRITNPFiqaPVEKVWRYWTEPDHITKWNQASEDWHAPRAENDLRVGGKFLTRMEAKDGSMGFDFGGIYDVMNRhEA 96  Paenibacillus s...
ZP_03852402    3 PIKIDITILA---PVEKVWTYFNEPKHITKWNFAHESWHCPSSENNLEVGGKFRNRMEAKDKSFGFDFEGVYDEIIPhQV 79  Chryseobacteriu...
YP_001838491   4 SIEIHALVAS---DTKKVWDYYTNPIHITKWNFADPSWHCPSAKVNLTKGGTYLARMEAKDGSFGFDFEAIFDEIKEfQF 80  Leptospira bifl...
ZP_01718971    8 KITVQVVVDK---TLEKVWESWIKPKHIVNWYFASPDWHCPKSENDLQPGGNFVFRMEAKDGSFGFDFGGVYQEVKKqEL 84  Algoriphagus sp...
Feature 1        # ##     ## # #          # # # #   ######### ###  #      
YP_001194059  78 IKYVMadgRKVEINFKEtl-eGVEVTESFDPETQnPEEMQRGGWQAILDNFKSYVEN 133 Flavobacterium johnsoniae UW101
YP_002884730  82 IQYRLedgRRVRISFSSeg-dQTKVVEVFDAESMnPVEMQRQGWQAILDNFTRYANG 137 Exiguobacterium sp. AT1b
YP_863496     83 LVYEIedgRMVTVIFSEed-nSTTIKQTFEPEDEnSKEMQQEGWQSILNTFKKYAED 138 Gramella forsetii KT0803
ZP_03970003   86 ISYTMadgREVSTLFSSkg-dTTIITTTFDAETEnDPEFQKQGWQAILSNFKKYVES 141 Sphingobacterium spiritivorum ATCC 33300
ZP_03851624   81 FTYTMpdgREVHVDFKEnn-gQTHLNVAFDPENQnPEEMQKGGWQAILDNFKKYTET 136 Chryseobacterium gleum ATCC 35910
NP_350271     88 ISYIMdddRSVEITFKPek-dKTYIVESFEAEKSnPIDLQQKGWQAILDNFKKYVEE 143 Clostridium acetobutylicum ATCC 824
YP_003013269  97 IGYTMedgRRVDIAFVDqg-nETKVIETFDAESSnPVEFQQAGWQGIMDNFKAYTEQ 152 Paenibacillus sp. JDR-2
ZP_03852402   80 IRYHMedgRNVEVIFDKiddnTTKVIEIFDPEKQnSVEMQRDGWYAILNNFHKYVEN 136 Chryseobacterium gleum ATCC 35910
YP_001838491  81 FSYTMtdqRKVTVTFLDnq-sNTEVIVKFEPENEnPIEMQKDGWQSILNNFKQYVET 136 Leptospira biflexa serovar Patoc strai...
ZP_01718971   85 ITYIMddgRAARIEFSElp-dGILIKETFEAESTnSVEIQRGGWQAIVDNFKSYTES 140 Algoriphagus sp. PR1

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