1XFS


Conserved Protein Domain Family
SRPBCC_CalC_Aha1-like_3

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cd08896: SRPBCC_CalC_Aha1-like_3 
Click on image for an interactive view with Cn3D
Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins
SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.
Statistics
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PSSM-Id: 176905
View PSSM: cd08896
Aligned: 34 rows
Threshold Bit Score: 195.145
Threshold Setting Gi: 85707955
Created: 31-Jul-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 43 residues -Click on image for an interactive view with Cn3D
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         # # #        ### ##    #              #       # # # #         # ## #  #     # #
1XFS_A        11 DLXLKRELAVPVNLVWRGLTepELLKKWFVPK-PWSISDCRVDLRPGGEFYTVXQDPe-GNKFPNSGCFLEVTDEKRLIW 88  Nitrosomonas eu...
NP_881988     14 DLVLERTIDVPPALVWQAWTqpEHIKHWLTPA-PWQTVRCDVDLRPGGRFRFVMRSPe-GEEHTHDCCYLEIVEGSRLVW 91  Bordetella pert...
NP_713394     14 DLVLERIIDVPRELVWKVWTtpEHLKPWFCPS-PWKTIDCEIDLRPGGIFRTTMQSPe-GENFPNLGCYLEIIPNERLVW 91  Leptospira inte...
YP_001413655  11 DLVLERTVDVPPRLVWRAWTepEHLMPWFCPR-PWATVECRIDLRPGGEFYTQMRSPegKDMEGGSGCYLEIEKERKLVW 89  Parvibaculum la...
ZP_00961163    8 DLSFTRRLAAPRALIWECWTspDHIPHFFIPA-PHQVTRCDIDLRVGGRFNTTFLVE--GQEMENTGVYLEVVPQTRLVF 84  Roseovarius nub...
ZP_01158134    9 DLVLVRQIAASPETVYRCWTepELLKQFFAPA-PGETVEADIDARPGGRFYTLMRFEe-HGEIGGEGCVLVAEPGRRFAW 86  Oceanicola gran...
ZP_01092697   30 DLVLERIVDVPRELIWTAWTtpEQVCHWFCPR-PWTVTDCEIDLRPGGIFRTTMCSPe-GEKFPNVGCYLEVIPGERLIW 107 Blastopirellula...
NP_970389      8 DLVLERVLDLTPEQVWKGWTtpEILTKWFCPE-PWKTIEAEVDLKPGGMFRTVMQSPe-GDKYPNVGCFLEVEKNKKLVW 85  Bdellovibrio ba...
ZP_01011369   11 DLELTRTVSATPATLWRCLTdpDLLAQWFCPK-PWQVRGAVIDPRPGGIFHTPMFGPngETQDAGPGCVLIADEGRTFAF 89  Rhodobacterales...
YP_002759594  16 DFAIERFIDAPPRLVWEALTkpEHIKEWYMPRqWGRVVRTELELRPGGAFSIDIAVGe-GQEVPNLGCVLDVVPNERLVW 94  Gemmatimonas au...
Feature 1        #                         ## # #          # # # #        ######### ###  #      
1XFS_A        89 TSALVKNYRPAVPAttsdkecahivXTAVIELQPts-sGTRYTACAXHNTPgqRKLHEEXGFHEGWGTTITQLEELLKQ 166 Nitrosomonas eur...
NP_881988     92 TNALLPGFRPAGGGgdv------paFTAVIRIEPhd-qGTRYTATAMHGTQagCRQHSDMGFHDGWGAALDQLVAHARN 163 Bordetella pertu...
NP_713394     92 TDALQPGFRPSPDPnhp-----fgfFTAIVTMEThg-tGTKYRATAIHGNEtnRKKHEDMGFHEGWGTALDQLVVYVKK 164 Leptospira inter...
YP_001413655  90 TSALGPGYRPAVARvhd------lfFTAWILMEPqg-qGTKYTAIAKHPDEasAKRHEEMGFHEGWNTVVDQLAEYMKT 161 Parvibaculum lav...
ZP_00961163   85 TDGYSEGWKPAPDPf----------MTAILDLEDdgagGTLYTATARHRSPeaRKSHEDMGFHDGWGTVADQLERYAQS 153 Roseovarius nubi...
ZP_01158134   87 TDCLGPDFRPNPNPf----------FSAEITFTAkd-gGCEYRVVARHVDAatAQRHEEMGFQSGWGTVADQLARLAES 154 Oceanicola granu...
ZP_01092697  108 TDMLLPGFRPAEQGf----------MTGIITLETve-gGTRYKAVALHADVatRKQHEEMGFHEGWSTVLDQLVEYVKS 175 Blastopirellula ...
NP_970389     86 TDVLAPGFRPVPAVesga----gfpMTAFILLEEhq-gKTKYTAVARHRSEedLKKHEAMGFHDGWGICADQLVKVMKS 159 Bdellovibrio bac...
ZP_01011369   90 TDAMTPGFHPKGSAf----------LTGVYMLEAte-aGTKVTARALHADGatRDSHESMGFFDGWGTAIDQLGDLAST 157 Rhodobacterales ...
YP_002759594  95 TSMLFPGYRPAVFDdi--------pITAVMTLKAeg-sGTRYVFTALHRSEadLQTNQTSGFYEGTKIAVEQFVERVEA 164 Gemmatimonas aur...

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