1Z94


Conserved Protein Domain Family
SRPBCC_CalC_Aha1-like_2

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cd08895: SRPBCC_CalC_Aha1-like_2 
Click on image for an interactive view with Cn3D
Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins
SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.
Statistics
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PSSM-Id: 176904
View PSSM: cd08895
Aligned: 22 rows
Threshold Bit Score: 180.558
Threshold Setting Gi: 103487204
Created: 31-Jul-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 43 residues -Click on image for an interactive view with Cn3D
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         # # #        ### ##    #             #       # # # #                 # ## #  # 
1Z94_A         4 TIRLHRVLSAPPERVYRAFLDpLALAKWLPPeGFVCKVLEHDARVGGAYKXEFLafa--------sgQKHAFGGRYLELV 75  Chromobacterium...
EAY66201      19 STRVSRHLNAPRGRVYRALLDpHAVEQWKVPdGMTCRVHAYDTREGGALRVSLSydapsagtgkttaRTDTYHGRFVTLV 98  Burkholderia ce...
YP_641256    135 TDRASRIIAAPLTRVFSALVDpDALLEWLPPrGMRGEFERFDGRAGGSYRLRLTyleapeaggksgaDSDVVEARFLDIA 214 Mycobacterium s...
YP_706645      4 TDRASRTIAAPPATVYGALLDrESLEAWLPPdGMRGRVERWDPRPGGGFRMVLTyldpadgpgktsdATDVVNVGFADLL 83  Rhodococcus sp....
YP_616765     10 TDHAERLIAAPLVDVFAAFTSaDTLARWLPPdGATGTFEQVDLCAGGGFRLRLTfddpev-etksddDGDVVDVHIPVLD 88  Sphingopyxis al...
ZP_01011309    7 TDRAERFIATSPEEVWAAQTDpDRLVRWLPPdDATMEVLAFDPTPGGAYRLRLTftetgv--gktqaDTDEVHGRFVALD 84  Rhodobacterales...
YP_677736      4 ATTNSKIIHATRQHVYEALTQkEALEFWLAPdQMTGKIHDFDLSVGGGYTMSLFytdnsi-kgktsgNEDRYTSTFIELQ 82  Cytophaga hutch...
YP_002466459  11 STIIRHHINAPRAIVYRALLDaHAVATWMVPtGMTSTVHSFDAREGGSFRISLTydtptg-tgkttaQTDTFHGRFVKLV 89  Candidatus Meth...
Q5YYS4         3 ATRIGKHIDAPRETVYRLLLDgEAVARWMVPdGMTSRVHEFDAREGGAFHITLTyddptd-tgkttdHTDSYRGRFLMLV 81  Nocardia farcinica
Q63N08         3 RDTAFRLVKASPSAVYAAFVAsEAVAQWLPPeGAMMEIQVFEPRVGGRFQMTLIfasap---gkstaNTDVVVGRFVELV 79  Burkholderia ps...
Feature 1            # ##                ## # #          # # # #        ######### ###  #      
1Z94_A        76 PgERIRYTDRF--DDAGLP--GDXITTITLAPls-cGADLSIVQEGIPDa----IPPENCYLGWQQSLKQLAALVEP 143 Chromobacterium vi...
EAY66201      99 PdQQIVEIDVFetDDPMLR--GAMTITITLSDea-gGTRVDAVHDGVPPg----VPAADNESGWEMALARLAALVEA 168 Burkholderia cenoc...
YP_641256    215 PdDRVVQEVAFesDDPRFA--GTMTMTWSVTAvd-aGTRVDFRADGVPPg----ISAEDHAEGMDSSLANLAACVET 284 Mycobacterium sp. MCS
YP_706645     84 PpECVVQRAVFeaDDPSYA--GTMTMTWHLAAag-dGTEVTVTATDVPPg----IDQAAHEAGIASSLANLASYVEG 153 Rhodococcus sp. RHA1
YP_616765     89 DgRLIVWEVAFesDDPRFS--GTMAMHWYLSRqg-gGTLVTVDAHHVPPg----ISAKDHVAGLNSSLANLARVVEG 158 Sphingopyxis alask...
ZP_01011309   85 EpTRIVQEVDFvsTDDAYA--GTMCMTWDHIAaa-gGTKVSVTAKNVPPg----IDRAVHEAALASSLAKLAAEVGG 154 Rhodobacterales ba...
YP_677736     83 PyEKVVHSITF--QSEKKEfeEAMIMEVFLEEkgkdVTNVTIFFKNIPAg----ITPEDNEAGTKESLDKLARYLEN 153 Cytophaga hutchins...
YP_002466459  90 PnAQVVEVVEFetPDPTLS--GEMTISYTLSDan-gGTDILPCTIGSRVaclplTTKSVGGCHWRNSRRSLSRAHDL 163 Candidatus Methano...
Q5YYS4        82 PhEQVVQLVEF--DTEDPDvqGEMTISYTLTEad-gGTDLIALHDKLPSg----LDPHDNEIGWRISLAKLAALAER 151 Nocardia farcinica
Q63N08        80 PqQRIVQAFEF--DSPDPVfaGAMTMRWELEAaa-gGTAVTVVAENVPPg----ISQTDHETGMNSSLTQLAAYVES 149 Burkholderia pseud...

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