Conserved Protein Domain Family
SRPBCC_CalC_Aha1-like_1

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cd08894: SRPBCC_CalC_Aha1-like_1 
Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins
SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.
Statistics
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PSSM-Id: 176903
View PSSM: cd08894
Aligned: 27 rows
Threshold Bit Score: 177.082
Threshold Setting Gi: 169629564
Created: 12-Mar-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         # # #        ### ##    #          #          # # # #        # ## #  #     # ## 
YP_001860271  15 QIVSTRVFDFPRDLVFGAWTDpAHLAHWWGPKGFTNSFHEFDLRPGGNWRFVMHGPDGvdYRNHSVFVEIVApERIVFDH 94  Burkholderia ph...
ACR13623      10 VLQTTRTYPWPADTIYQAFADpERLAKWWGPNGFSNTFETFGFAEGGEWRYTMHSPDGqdFKNVCVFVELIPaEKLVIKH 89  Teredinibacter ...
ZP_02733873  160 EIVNARVFDAPRERLFRAFTDpEQLKHWWGPDGFTNTIQAFDPRPGGVWKLVMHGPDGadYHNESVFAEVAEpLRVVFDH 239 Gemmata obscuri...
YP_002136355  20 TVSTARVLGASPDQVYAAFVApERLARWWGPRGFRNTFQEFEPRPGGRWRLVMHGPDGvdHPNESVFETLLPgERIVIRH 99  Anaeromyxobacte...
YP_001793175 154 SFIHSRLIDATPAQVFDAFSHpERLARWWGPDGFSSTFERFDLRAGGAWQFVMHGPDGarYLNTNVFTRVEPpDRVEIEH 233 Leptothrix chol...
YP_316064      8 SDHRTHVIPATPAEVFAAIRDpDRIARWWGPEGFTSTIHTFEFHPGGRWLLTMNGPDGkdYPNESRFTRIETdRLFEIEH 87  Thiobacillus de...
YP_285925      5 IFRNSRALPFPPEAIFEAFASaELLATWWGPAGFTNTFEVFEFKPGGRWKFVMHGPDGtnYPNESNFVELVPgRKVVIRH 84  Dechloromonas a...
ZP_01882070   13 EIVTSRIVNAARPKAYLAWADpDHLKNWWGPAGFSNTFFEFDFKVGGRWDFTMHGPEKgnYQNLCEFTRIEEpFLIAWTR 92  Pedobacter sp. ...
ZP_04771948  176 EIVTSHRYAASPEALFALFADpQHLKQWWGPDGFTNSIPVFEFREGGEFRIIMHGPDGrdHDNHKRFVEIVEnERIVFDH 255 Asticcacaulis e...
YP_001703213   2 RLHASREIAASPSSIFAAFADeARLVRWWGPNGFTSTFQSFALEPGRIWTFVMHGPDGrdYKNQISVLEVAPnSKIVLHH 81  Mycobacterium a...
Feature 1               ## # #          # # # #      ######### ###   #      
YP_001860271  95 vsg-pyFRVTATFDAlsdaQTRITFRMLFETPavcaQVKTFAVKANEENFDRLQKELKR 152 Burkholderia phymatum STM815
ACR13623      90 dsa-prFTLTITLEEsn-nQTLLTWTQKFEDPqvasAVRHLAEPGNEQNLDRLGENLNR 146 Teredinibacter turnerae T7902
ZP_02733873  240 iepvhrFRMSMTFDDes-gRTRLTWHMRFEDAaeaqRVRGFVVAANEQNFDRLARHLGT 297 Gemmata obscuriglobus UQM 2246
YP_002136355 100 lsg-hrFTLTVTLAAeg-aGTRLGWRQRFDSAqeceAVRRFVVPANEENLDRLEAELAR 156 Anaeromyxobacter sp. K
YP_001793175 234 lsedhhFILEITFSGqg-nQTLVGWRQTFDSVahrqLIAPWVEPANEQNLDRLQREVAR 291 Leptothrix cholodnii SP-6
YP_316064     88 lng-hhFVLTLELRPha-aGTEAVWRQTFDTPahyaRIADFVAAANQQNLERLAAEVAR 144 Thiobacillus denitrificans ATCC 25259
YP_285925     85 dca-pyFTLTITLTPva-gGTEVTWEQVFDDAqvaqAIKHILMPANEQNLDRLTAVLQR 141 Dechloromonas aromatica RCB
ZP_01882070   93 isk-plFDVIVTFEEidsdTTKVVFRQVFRTAeecnKIRPFVEDKNEENMDKLEAELKI 150 Pedobacter sp. BAL39
ZP_04771948  256 lqpthqFRMSVEFIPhg-eHTDMIWRMDFAPSeqeeLLKTFIPQANEQNFVRLDTYLKT 313 Asticcacaulis excentricus CB 48
YP_001703213  82 vsg-prYLLTVTLEStsdgGTTVGWNQEFENPavgrRLAPLLTSANEEVLTRLGTEVTG 139 Mycobacterium abscessus

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