Conserved Protein Domain Family
SRPBCC_CalC_Aha1-like_GntR-HTH

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cd08893: SRPBCC_CalC_Aha1-like_GntR-HTH 
Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain.
SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. Some proteins in this subgroup contain an N-terminal winged helix-turn-helix DNA-binding domain found in the GntR family of proteins which include bacterial transcriptional regulators and their putative homologs from eukaryota and archaea.
Statistics
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PSSM-Id: 176902
View PSSM: cd08893
Aligned: 33 rows
Threshold Bit Score: 144.308
Threshold Setting Gi: 149923730
Created: 30-Jul-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         # # #        ### ##     #         #      # # # #              # ## #  #     # #
YP_001526619 112 KHVYEHFLRAAPEAVWAILTDd-AKTPLWQhfnmtSTTDWRVGGAITFFveg---------rpMIVGEILELAPpTRLVH 181 Azorhizobium ca...
YP_946914    137 EKIFEIYIKTTPERLWEAITNs-DIRSKYQfg-ntFTSDWTPGSRFEMHnvka-------dapLGEGENIEVDPpRRLVQ 207 Arthrobacter au...
YP_799757    115 KQVYTLYIKTNANKLWDTLIQs-SITPEWFdg-maVTFEPKVGAKLTYDikgqd----gnklsVVEGNVLEFDPqKKLAY 188 Leptospira borg...
ZP_00995825    4 QHIYQLYIRAEIDDLWRALTDp-ESTRQYFha-thWISPPVVGEAFQTHlpd--------ggvAVDGVVEVVEPpRRLVH 73  Janibacter sp. ...
YP_705300      7 IQIYAVYIKATPEAIWDAITKp-EWSQQYGyg-glVDYDLRTGGAFRSRaddamkeypgvpdvIVDGEVIESDPpKKLVQ 84  Rhodococcus sp....
YP_001413657  14 DFLYVIHIDAKPEDVWAALTDn-KTERAWWgg-trQDSSFEPGSPIIYRrkg---------gvDVRGEILESEPpRRLVY 82  Parvibaculum la...
YP_003059650   5 EFNYTIYIDAPPQKVWDTITEh-EGPRDWWsd-thMLSTFKSGSTIVFRrge---------ndDVQGEVLESEApHKLIH 73  Hirschia baltic...
YP_002769946   2 DLRFDFYIGATPEQVWHALTSdeGVKSTFFgc--tIRSTFQVGDEMAYVgpgka----gddtvHVYGKILQFEPhHIFSF 75  Brevibacillus b...
YP_001543348 114 KLVYQTIIRASQQQVWEAIIKp-EFTTRYYyg-ctVDTNLAVGSAFNYQrsn--------gaaIVEGQVVEVDApNRLVH 183 Herpetosiphon a...
YP_003014255   2 ELNYVFYIGASPEQVWQTLVSpeGTRSTFFgt--vLNSTLEPDASFEYVgpgae----gentvHVYGTILKADPgKMLSY 75  Paenibacillus s...
Feature 1        #                ## # #           # # # #             ######### ###  #      
YP_001526619 182 SFsarwspd-vagdppSRVTWELSAIPG--GTKLTLTHDNFGGdt--------aTSRAVTGGWPESLSRLKTLVET 246 Azorhizobium caulin...
YP_946914    208 TMralwged-vkaegtSRITWEIEPVGD--SCHLTVTHDQLREg----------ANDQLYGGWPMILSGLKTWLET 270 Arthrobacter auresc...
YP_799757    189 TFrlsaepk-atkdraSRVTYELEPSGPd-SVKLTVTHDDFDGkt--------tTFFGVSQGWPRHLSNLKTYLET 254 Leptospira borgpete...
ZP_00995825   74 TWhpvyddd-laaeppSRVAWELTPAGDg-LTHLRLTHSALDQsp--------lTSENVRDGWVFILDSLKTLLET 139 Janibacter sp. HTCC...
YP_705300     85 TWrmlmda--dnvegfTTLTYEIVQSSRpgVAKLTVTHDLTNApglaemvagkrESEGAGGGWNEVLSGMKTLLET 158 Rhodococcus sp. RHA1
YP_001413657  83 TFqvegpgp-qhdegpSIVTYDVAANGK--LTKLTVSHTNFPKns--------aVLKGISSGWPGILSGLKSALER 147 Parvibaculum lavame...
YP_003059650  74 TFrvggfgp-myhegvSLVTFQIETNGP--STMLTVKHQGFPDns--------aVLKGVSKGWPAILSSMKSYIET 138 Hirschia baltica AT...
YP_002769946  76 TEhpgpayyenhaelqSRVTITLEPVGG--CTKLTLIQDQWTEnh--------pSHASASNNWPMMLSSIKTYAET 141 Brevibacillus brevi...
YP_001543348 184 TYhslwpp--mnedapTKVTWELEAMPGg-ITKVTVVHEDFQGet-------atYQGLNSGGWTWILSNLKTLLET 249 Herpetosiphon auran...
YP_003014255  76 LEhpgpsyrdnhaeleSRVTFTLETVGS--CTKLTLVNDQWTLdh--------pSFANSKEHWWMMLSNIKTYTET 141 Paenibacillus sp. J...

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