Conserved Protein Domain Family
RHO_alpha_C_3

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cd08887: RHO_alpha_C_3 
C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases
C-terminal catalytic domain of the oxygenase alpha subunit of a functionally uncharacterized subgroup of the Rieske-type non-heme iron aromatic ring-hydroxylating oxygenase (RHO) family. RHOs, also known as aromatic ring hydroxylating dioxygenases, utilize non-heme Fe(II) to catalyze the addition of hydroxyl groups to the aromatic ring, an initial step in the oxidative degradation of aromatic compounds. RHOs are composed of either two or three protein components, and are comprised of an electron transport chain (ETC) and an oxygenase. The ETC transfers reducing equivalents from the electron donor to the oxygenase component, which in turn transfers electrons to the oxygen molecules. The oxygenase components are oligomers, either (alpha)n or (alpha)n(beta)n. The alpha subunits are the catalytic components and have an N-terminal domain, which binds a Rieske-like 2Fe-2S cluster, and a C-terminal domain which binds the non-heme Fe(II). The Fe(II) is co-ordinated by conserved His and Asp residues. This group contains a putative Parvibaculum lavamentivorans (T) DS-1 oxygenase; this organism catabolizes commercial linear alkylbenzenesulfonate surfactant (LAS) and other surfactants, by a pathway involving an undefined 'omega-oxygenation' and beta-oxidation of the LAS side chain. The nature of the LAS-oxygenase is unknown but is likely a multicomponent system. This subfamily belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket.
Statistics
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PSSM-Id: 176896
View PSSM: cd08887
Aligned: 26 rows
Threshold Bit Score: 201.767
Threshold Setting Gi: 254481650
Created: 31-Jul-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                         ## ## ##   #                                                   
YP_001413049 194 YETRVLRARLNWKLVIDTFLETYHLSTLHKNTIa-PILHSNLGTfDGMARNLRMiga--------rktIDALRQRPESEW 264 Parvibaculum la...
YP_778114    194 FGTRALRKRLNWKLAIDTFLESWHIDKLHRETIn-PIFLPGIGLvDTFGDNMRLtfp--------rrsIVDMRNQPEENW 264 Burkholderia ce...
ZP_01626630  194 YVGQRVIHGANWKVALDGYLEGYHFQAAHPETIa-PRTYTNVMAfEAYGPHMLVgyp--------aktIEKLKDIPKDEL 264 marine gamma pr...
YP_001165869 195 YHKSKAMKGANWKVAYDGYLEGYHFQAAHTNTVa-TRSPSNRASyEGFGPHIRLgfp--------qntITRLHELPRDEW 265 Novosphingobium...
ZP_01225514  195 FCGQRKIDGANWKVAYDGYLEGYHFAAAHPDTIa-ERTYSNVMQfDAYGPHTLIcfph-------laiKENLADVAPEDY 266 gamma proteobac...
YP_496475    193 HFESRSLPGANWKLAFDAHLEFYHLPVLHRATF--GPGMSNLAEyFFHGPHQRLglvtnaghvleqddVASLATLPEGEW 270 Novosphingobium...
YP_001165876 194 YMGSRVIEGANWKIAYDGYLEGYHFASLHPQTIf-PRTPSNCMHyEGFGPHQRIgfpq-------hriAEALKDVPREEW 265 Novosphingobium...
YP_479310    176 VGEKVLDFPINWKFALDTFAENYHFATVHRDTFa-LITKSNCALfDSFGPHHRLvfp--------mrhITDLADKPEEEW 246 Frankia sp. CcI3
NP_959867    219 HTQREFTSEVSWKGALEAFAEGYHFPYVHGQSLigQNTLANTMVyDEFGKHHRIgfp--------ftwITNAATDPAASL 290 Mycobacterium a...
YP_001511085 195 SEPHPHEVAANWKVTLDTFRENYHFNYLHRKTLr-TYAYGGVLTfDPLGRHLRNasa--------lrsIDALRDTPESEW 265 Frankia sp. EAN...
Feature 1               ## #       # #         # #                                     #  ##     
YP_001413049 265 dlv--rhSALVYVLFPNTVFIMq---GDHLETWRVYPGDs--VDESKMHVSLYTPepavt-dkarKYWTKNMDLLm---- 332 Parvibaculum la...
YP_778114    265 dll--rhTLIVYVLFPNTLLNWq---GRHFEIWRMFPANdedPDQCIAEASLYTPtpvgn-aqtdAYWRRNFDLLm---- 334 Burkholderia ce...
ZP_01626630  265 wqhendgYDFIRLFFPNVSIFVa---PEITQIAQLIPGPg-pLENTTVLHFIHHTkped--aeeiAGLEQMADWLm---- 334 marine gamma pr...
YP_001165869 266 grqenkgYDFIRMLFPNMSFFLa---PEMGQLAQLFPGP---QANQNTTVMNYIFpvkpeteeglAALDQMCDFFf---- 335 Novosphingobium...
ZP_01225514  267 hkhenngYDWIRTLFPNISLFVa---PEITLVSQIIPGP---LPNQNTTYINFIHptkp--agedTELQGMMDFFq---- 334 gamma proteobac...
YP_496475    271 pat--plLFGEWIIFPNVSINCfykgGRGVIISQVFPGA---SVGESVTVQMFLHenppa-edlvADARAMSDFLg---- 340 Novosphingobium...
YP_001165876 266 gtqenngFDFVRIMFPNVSAFIa---PEITQIAQLFPGP---TPGENRTVLNYLRrep----irdEEDRANVEAAmnf-- 333 Novosphingobium...
YP_479310    247 epl--hnLVVIYALFPNIVLSVt---VANGEVFRVYPGSg--PGHSITYHQNASPmdltd-eatrTAADEIFEYAh---- 314 Frankia sp. CcI3
NP_959867    291 epl--anMGVIYWVYPNLILANs---PVGLEIIDMLPAGa--PTRCTVRHSWMARv--------pAADDEMRAAYdavfe 355 Mycobacterium a...
YP_001511085 266 gdv-tqhFSPQYSLFPNTCLTFd---SRHVELWQILPVD---STTSRVLHSVYLRpgl-----spEERAKAVDMApwi-- 331 Frankia sp. EAN...
Feature 1             ##  #                                        
YP_001413049 333 ---ATVQQEDFPLAENIQRDFHSGAQDFvTFGANepALAYFHRSIKKTLG 379 Parvibaculum lavamentivorans DS-1
YP_778114    335 ---NVVEKEDFDLAEQIQRGFNARTQQSiTFGRHepALGYYHERLRRAVA 381 Burkholderia cepacia AMMD
ZP_01626630  335 ---QVVDEEDYQVGLQVQRGLQSGHLADvIFGKNesGNQFAHRCIEYYAE 381 marine gamma proteobacterium HTCC2080
YP_001165869 336 ---DVVEEEDYFLGLKVQNGLESGAMTHqTFGRNepGNQFFHKWVAYYLD 382 Novosphingobium aromaticivorans DSM 12444
ZP_01225514  335 ---EVVDVEDYQVGLKIQKGLESNAHANvTFGRNeaGNQLFHKWVEWYLA 381 gamma proteobacterium HTCC2207
YP_496475    341 ---QVVGEEDLPMSRGQQEVLESGLLPRvQFGRNegGVQHFHEWIDRFVE 387 Novosphingobium aromaticivorans DSM 12444
YP_001165876 334 -frDVTYTEDYLIGLEIQKGLESGAHDDlVFGRNerGNQYFHEWLDWYLQ 382 Novosphingobium aromaticivorans DSM 12444
YP_479310    315 ---ATVRDEDYRMAIDIQKNMASGVRPElVFGRNepGLHHRHAVIDEALA 361 Frankia sp. CcI3
NP_959867    356 gvhAAVRDEDFAMLPQCGEGVRHGQHDHmIIGRNeiAVQHMIRVFAHELG 405 Mycobacterium avium subsp. paratuberculosis K-10
YP_001511085 332 -ceTVVDGEDFWVAGRTEPGIRAGIVDTvVFGRNepAPQHLHHGFTETIQ 380 Frankia sp. EAN1pec

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