Conserved Protein Domain Family
RHO_alpha_C_2

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cd08886: RHO_alpha_C_2 
C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases
C-terminal catalytic domain of the oxygenase alpha subunit of a functionally uncharacterized subgroup of the Rieske-type non-heme iron aromatic ring-hydroxylating oxygenase (RHO) family. RHOs, also known as aromatic ring hydroxylating dioxygenases, utilize non-heme Fe(II) to catalyze the addition of hydroxyl groups to the aromatic ring, an initial step in the oxidative degradation of aromatic compounds. RHOs are composed of either two or three protein components, and are comprised of an electron transport chain (ETC) and an oxygenase. The ETC transfers reducing equivalents from the electron donor to the oxygenase component, which in turn transfers electrons to the oxygen molecules. The oxygenase components are oligomers, either (alpha)n or (alpha)n(beta)n. The alpha subunits are the catalytic components and have an N-terminal domain, which binds a Rieske-like 2Fe-2S cluster, and a C-terminal domain which binds the non-heme Fe(II). The Fe(II) is co-ordinated by conserved His and Asp residues. This subfamily belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket.
Statistics
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PSSM-Id: 176895
View PSSM: cd08886
Aligned: 7 rows
Threshold Bit Score: 241.244
Threshold Setting Gi: 55376914
Created: 27-Apr-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                         ## ## ##   #                                                   
YP_300023    184 ARKLTYEMKANWKVVVDNYLECLHCQTAHPALVes-------iRMETYKHEVRGIYTSqvgq----trsGSDAFTYDSda 252 Ralstonia eutro...
YP_001585970 195 AARFVSETPANWKSIVDNYLECYHCGPAHPGFSds-------vKIDQYTHTLHGNWTLq---------fGHAESSERSfk 258 Burkholderia mu...
ZP_00958891  190 GHRLTYEINSNWKNVVDNFLECYHCPTAHKDFCdl-------vDMDTYKVTTYGIYSShma------daGQGENSAYDvs 256 Roseovarius nub...
YP_367390    191 ARRLQFDIRSNWKNVVDNFLECYHCPTAHKDFVsl-------lQFDTYKVTTHGIYSShma------kgGNAGNTAYSve 257 Burkholderia sp...
YP_134765    203 AARYVSEVECNWKTFAGNYSECDHCHANHQDWItdielaeselEVNDYHWILHYTHDEd----------VEDEMRIHDe- 271 Haloarcula mari...
YP_001374098 181 THDKKRVIKANWKAFIDNYLECDHCHTAHPSFVat-------lDMKDYQIITCENYSVqgsmvkpnknyGSVNLNEAEm- 252 Bacillus cereus...
NP_288238    188 AARFTTRTPANWKNIVDNYLECYHCGPAHPGFSds-------vQVDRYWHTMHGNWTLq---------yGFAKPSEQSfk 251 Escherichia col...
Feature 1                ## #       # #        # #                             #  ##   #   #     
YP_300023    253 p-----ntDFAAYWLWPNVTLNVLPGdGNYGVFYMFPVDADTTIQHFEFYFRDatPTAEQEQLIDYYKNVLkPEDLSIVE 327 Ralstonia eutro...
YP_001585970 259 ldpsiqdaSFQGFWAWPCTMFNVPPGaDFMTVIHEFPVNAEVTLQHYDIYFLNeaLTDYQKNLIEWYRNVFrPEDLRLVE 338 Burkholderia mu...
ZP_00958891  257 na---tvrTHAVWWLWPTTCLMRYPGrSSMIVLNIIPVGPDKTLETYDFYLETpePDAMERDAIRYLDEVLqVEDISLVE 333 Roseovarius nub...
YP_367390    258 ga---tcdDHAVWWVWPNTCLLRYPGrANFLVLNIIPVAPDRTIETYDFYFESaePTPQEIEAINYVRDVLqQEDIDLVE 334 Burkholderia sp...
YP_134765    272 -------hEAKFYYFWPNFTVNMYGTaDGYGTYIIDPIDEGRFQLIADYYFSDeeMTDAEQEFVQTSRQLQ-EEDFELVE 343 Haloarcula mari...
YP_001374098 253 -------qGGSFYWLWPNLMITIYPGpGNMATIQMIPIDHETTLGVYTYYFRDenLTQEEKDLVAFAEQVR-NEDVELVE 324 Bacillus cereus...
NP_288238    252 fee-gtdaAFHGFWLWPCTMLNVTPIkGMMTVIYEFPVDSETTLQNYDIYFTNeeLTDEQKSLIEWYRDVFrPEDLRLVE 330 Escherichia col...
Feature 1                                                   
YP_300023    328 SVQRGLKSRGYrnGQGPLLvtddrtsaIGEHGVQHFQQMVLDA 370 Ralstonia eutropha JMP134
YP_001585970 339 SVQKGLKSRGYr-GQGRIMvdqr-rsgISEHGIAHFHHLLAQK 379 Burkholderia multivorans ATCC 17616
ZP_00958891  334 SVQRGMNTPAF--AQGRIVsdps-gsgKSEHAVHHFHGLVLDA 373 Roseovarius nubinhibens ISM
YP_367390    335 SVQRGMSTPAF--ESGRIVsdpq-qsgMSEHALHHFHGLVLKA 374 Burkholderia sp. 383
YP_134765    344 RQYEGLKSGAL--AQAQLG--------PNEHTVHRLHRLAQEA 376 Haloarcula marismortui ATCC 43049
YP_001374098 325 LEQVGFRSRAF--QKGIYS--------SSEQAVVQFHEMVLEA 357 Bacillus cereus subsp. cytotoxis NVH 391-98
NP_288238    331 SVQKGLKSRGYr-GQGRIMadss-gsgISEHGIAHFHNLLAQV 371 Escherichia coli O157:H7 EDL933

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