Conserved Protein Domain Family
RHO_alpha_C_AntDO-like

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cd08879: RHO_alpha_C_AntDO-like 
C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases
C-terminal catalytic domain of the oxygenase alpha subunit of anthranilate 1,2-dioxygenase (AntDO) and related Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs, also known as aromatic ring hydroxylating dioxygenases). RHOs utilize non-heme Fe(II) to catalyze the addition of hydroxyl groups to the aromatic ring, an initial step in the oxidative degradation of aromatic compounds. RHOs are composed of either two or three protein components, and are comprised of an electron transport chain (ETC) and an oxygenase. The ETC transfers reducing equivalents from the electron donor to the oxygenase component, which in turn transfers electrons to the oxygen molecules. The oxygenase components are oligomers, either (alpha)n or (alpha)n(beta)n. The alpha subunits are the catalytic components and have an N-terminal domain, which binds a Rieske-like 2Fe-2S cluster, and the C-terminal catalytic domain which binds the non-heme Fe(II). The Fe(II) is co-ordinated by conserved His and Asp residues. Oxygenases belonging to this subgroup include the alpha subunits of AntDO, aniline dioxygenase, Acinetobacter calcoaceticus benzoate 1,2-dioxygenase, 2-halobenzoate 1,2-dioxygenase from Pseudomonas cepacia 2CBS, 2,4,5-trichlorophenoxyacetic acid oxygenase from Pseudomonas cepacia AC1100, 2,4-dichlorophenoxyacetic acid oxygenase from Bradyrhizobium sp. strain HW13, p-cumate 2,3-dioxygenase, 2-halobenzoate 1,2-dioxygenase form Pseudomonas cepacia 2CBS, and Pseudomonas putida IacC, which may be involved in the catabolism of the plant hormone indole 3-acetic acid. This subfamily belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket.
Statistics
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PSSM-Id: 176888
View PSSM: cd08879
Aligned: 38 rows
Threshold Bit Score: 215.286
Threshold Setting Gi: 15597279
Created: 31-Jul-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                         ## ## ##   #                                                   
BAB32747     198 PGKSAYTYDGNWKLQNENGLDGYHVSTVHYNYVatv----qhRQQVNSEKGLTSadtldysklga----------gdket 263 Pseudomonas res...
NP_885027    190 AGFLQHRAKANWKFMLENETDGYHPGFVHGSIFqvtn-spiaNLYGKDSTALTR-------------------------- 242 Bordetella para...
YP_884202    191 AGWLQHLTRANWKLLAENETDGYHPQFVHGSIFgvtg-stigPLYSDSSTAVTR-------------------------- 243 Mycobacterium a...
NP_890659    190 AGCHRYIYEGNWKLQTDNLGDMYHPVACHSSTVdedg--kqfKRRPGDEGGRAAflgadgep---------------ivi 252 Bordetella bron...
YP_713611    195 AGWMKHDMRCNWKMVMENNVDGYHALFTHASVYd--------AVKPAKVSHVPSkvev---------------------- 244 Frankia alni AC...
YP_001264652 190 GNSFRSIYPCNWKIYLENLHDGVHPKFVHTSSV---------VASTEVRSGLKSsasgtedddfvlgviaangqsfgdmd 260 Sphingomonas wi...
NP_770040    200 ATPIRYMHTCNWKMLVENQTDTCHPMVAHESSAgtavkvwkrEQGDSTETPMAVqlygpfmspy------------efye 267 Bradyrhizobium ...
YP_997439    193 GGCLRFMHQCNWKMFVENLNDTMHPMVAHESSAgtak-rmwaDKPEDEPKPMAIeqfvpfmsdy------------kffe 259 Verminephrobact...
ZP_01626570  192 GGVLRYEHDCNWKFILENLNDTMHPMVVHESLV---------KAAESYIATLPQeaveqrreaeiipp---fgasyenfe 259 marine gamma pr...
YP_997431    193 GGVLRNIIHCNWKIYLENINDTVHPMSTHESAIha-----arALRDSHDPGAPKpmaleqilpfgs--------gheffd 259 Verminephrobact...
Feature 1                                                                     ## #       # #     
BAB32747     264 ddgwfAFHNGHSVLFSdmpnpsvr-----------pgyatimPRLLQEYGQGK-AQWMm-hRLRNLNIYPSMFFLDqisS 330 Pseudomonas res...
NP_885027    243 -----DYGNGHTEFDLrpewrridkplyw-fgssvermadyaVAMDQAYGAER-ARQImidGSPHTMIFPNLFIAE---I 312 Bordetella para...
YP_884202    244 -----DLGNGHSENDLrpefrkfaqpmrw-fgttesrvpeyvKAMRQVHGAYA-DRVLi-eGAPHVMIFPNLFIAE---I 312 Mycobacterium a...
NP_890659    253 qtgvrGFLRGHSSEASlfgandivkeet---rqrggiideyrSLLIEQHGVEK-TDEIlknRRHSMTLFPNLDVLMv-qT 327 Bordetella bron...
YP_713611    245 --yvrDLGNGHSEIDYakeytrldeefiwfgrirreklpqyvAAMEEARGPAD-THRAfvvGPPHTLIFPNLFLAE---M 318 Frankia alni AC...
YP_001264652 261 klqvnAYPNGHSSMRGfreavtrs-----------gpfetlrKELAERHGAEK-SDEIlarNWHNMCVYPNLSMHPg-fL 327 Sphingomonas wi...
NP_770040    268 qsgirIWPNGHGHTGVansihsny-----------sdvpgylDQMVAAYGEKR-AHEIlgeVRHNTVYFPNIMVKGa-vQ 334 Bradyrhizobium ...
YP_997439    260 dmgirTYDNGHSFTGVhfsihsky-----------kaiaaydDAMQARYGAQKtAQILg-mARHNTVYYPNLTIKGa-iQ 326 Verminephrobact...
ZP_01626570  260 nsgitGFEYGHHYDGGktsihady-----------svdpdyhAAMVAAYGETR-TREIyafNTHNVLYYPSLTIKCa-iQ 326 marine gamma pr...
YP_997431    260 amgarVFANGHSELGVnfsihsny-----------aplpeyeAALRTAHGPARaAEILq-rAPQNAVFYPSLSVKGs-pQ 326 Verminephrobact...
Feature 1        # #                                 #  ##      ##  #                            
BAB32747     331 QLRIIRPIAWNKTEINSFCLGVVGesDADRENRIRQFEDFFnv-sGMGTPDDLVEFREAQRGFQARLERWSDISRGvgkw 409 Pseudomonas res...
NP_885027    313 QIFVLQPVSVEETIQHVTAVQFKD--APDINRRLRQQTMGSvgpaGLLLADDTEMYERNHRGAKIRDPEWLMLTRGlhre 390 Bordetella para...
YP_884202    313 QVFNIQPVAVNECVQYSTAVQLAGa-PELNRRMVSQCIGSVgp-aGMLLADDTEMYERNQEGLAALSPEWLDIRRGlnre 390 Mycobacterium a...
NP_890659    328 SVRVVIPLAYNRTEVRIYPVHLDGapDELNRQIIKFLNITHsa-aSFIQTDDLEAFKRQQEGLAARSPQWLIVARGq--- 403 Bordetella bron...
YP_713611    319 NIMTVEPLGPGRAIAYTTPALIPGa-DEVNEKTLRRSEGAMgp-aGFLIADDGEIGARNQLGLAAGSPEWVVLRRGeesd 396 Frankia alni AC...
YP_001264652 328 QLRTLTPLSTDRTMVEVWCMRLVGapDEIYRRAVMYANTVHap-sSVIKPDDLEAYQRVQAGLQTDSAQWVSNHRRagre 406 Sphingomonas wi...
NP_770040    335 ILRNFIPIAVDKTLVESWVYRLVGapDKLYERALMYNRFINap-tSIVGHDDLEMYERAQEGLKSNGNQWVNLRRLy--- 410 Bradyrhizobium ...
YP_997439    327 AIRVVKPIAVDKTLIESWTLRLKGapPELLQRTSMYSRLINsp-fSVVGHDDLQAYRGMQAGLHASGNEWVSLHRNyepg 405 Verminephrobact...
ZP_01626570  327 NIRIIRPVSVDRFVVESWSFRLKGapDSMLQRTVLYSRLINsa-mGMVGPDDLEVYRRAQKGLECPANDWVEFHRQy--- 402 marine gamma pr...
YP_997431    327 AIRVIRPLAANRTLIEAWSLRAAGapALLFERAMSYNRLVFsp-mSVLAHDDVHLFESIQQGLRADGNEWVSLHRNh--- 402 Verminephrobact...
Feature 1                                                    
BAB32747     410 vegptansetiGISPVLTGtef----thEGLYVNQHGNWQRFLL 449 Pseudomonas resinovorans
NP_885027    391 r------kdenGYTVGHSTd--------EVPQRGIWRHYFKLMQ 420 Bordetella parapertussis 12822
YP_884202    391 a------idenGFTIGAATd--------ETGMRGFWSHYQTLMS 420 Mycobacterium avium 104
NP_890659    404 -----------GSEIDEGNgayfgprasEVGQRMRHQYWRELMM 436 Bordetella bronchiseptica RB50
YP_713611    397 i------tdetGIVNHDKSa--------ETPQRGWWKHWSQVLT 426 Frankia alni ACN14a
YP_001264652 407 -------eigeGVKTDSALs--------EHFIRNQYQAWAHYMS 435 Sphingomonas wittichii RW1
NP_770040    411 ----------eGHEEQDVTavin--gtsERQMRNQFHAWAKFMT 442 Bradyrhizobium japonicum USDA 110
YP_997439    406 -------ewtgGEVTTGGTn--------ELPMRNQYRSWVLRMT 434 Verminephrobacter eiseniae EF01-2
ZP_01626570  403 -----------GKDRILADrveg-ggtsDLDMRTQYRAWKAYME 434 marine gamma proteobacterium HTCC2080
YP_997431    403 ----------dAAETQQASvttn--gtnELLMRNQFRAWAQSMV 434 Verminephrobacter eiseniae EF01-2

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