Conserved Protein Domain Family
START_2

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cd08877: START_2 
Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family
Functionally uncharacterized subgroup of the START domain family. The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. For some mammalian members of the START family (STARDs), it is known which lipids bind in this pocket; these include cholesterol (STARD1, -3, -4, and -5), 25-hydroxycholesterol (STARD5), phosphatidylcholine (STARD2, -7, and -10), phosphatidylethanolamine (STARD10) and ceramides (STARD11). Mammalian STARDs participate in the control of various cellular processes, including lipid trafficking between intracellular compartments, lipid metabolism, and modulation of signaling events. Mutation or altered expression of STARDs is linked to diseases such as cancer, genetic disorders, and autoimmune disease.
Statistics
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PSSM-Id: 176886
View PSSM: cd08877
Aligned: 14 rows
Threshold Bit Score: 219.479
Threshold Setting Gi: 219123745
Created: 31-Jul-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative lipid
Feature 1:putative lipid binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                     ##         #             # #           #   #     #  
EER02592       80 IHMMEERVASMKEVRRALdkn-gdGWVLQRDge---giRTYYKHNKDtpsvHSFRIQGIIDC-PFFDLMALLSEVDFYKD 154  Perkinsus mar...
XP_001443697   62 IQTFHKEATFLKQQLSDNk-----DWIHDCNtq---yfQMSYKFIPNst-nVALKFESVMKL-PIINACALIYQTELFNN 131  Paramecium te...
EEE28390      214 ERVMQQPLHPLVTGRKPN------AWHHSVEee---dmRVFVRNYADnrelLTFRIEGDVEA-PLEAILSVLNEVDLFKT 283  Toxoplasma go...
EEF38297      125 LDMLRSASVSEHETSKTGqts-hsEWKLKDDne---eyRVMYRPGPHgtplHTLLVEGYVDG-PLDICLCISWELTLYRK 199  castor bean
XP_001749540   83 IRVMRATAEAVLHVREDLda--veAWTLQRQdd---nsTTYYRLEDDsp-fVCVRVEGWIDE-PLRQIMAVLYEVEYHPE 155  Monosiga brev...
NP_001154608  111 IEKLRSVSTKDQDLSKSSteasygDWKVKHDdk---dcRVMYREGLKgspfHTLLVEGCTDG-TIEDCLCVCWESSFYEK 186  thale cress
XP_002182179  156 LRHFLELATISERIRKDLteptseGWTKQGEshgnrdfTTYYKIEDGg--kLKCRIESVIESsLYVPFLAVMNETELYDT 233  Phaeodactylum...
XP_001007735  389 IELIKDETDLINYNLEVLqv--eeGWITEKEkg---kiKISYQYPDSn--sLSLRMESELDL-PLRNLLCLGNEFEYFKD 460  Tetrahymena t...
XP_001429898  238 IDMIQDKYVTMQHNLNELds---dGWVIEKNtk---qlVIKYKIDSKns-tVTLFMDSVFEA-NITKLMALINEIELYQN 309  Paramecium te...
XP_001026223 7778 ENKIGKELDYYQRIYQQLilt-tkGWQQEKTkh---gmSIQYKKIPNsk-lLALRMECEEMEmNIKVLISIVYEIELYQM 7852 Tetrahymena t...
Feature 1         ##         ##                  # #### #  # # #                    #             
EER02592      155 WIPSyk---flGIRDSKRIAEPRatqMLLHIVAALPWpFHNRDLVISVDGIDcigpyedpRQIVILLKSESgtsyepy-- 229  Perkinsus mar...
XP_001443697  132 WVPF-------CKVSKGLKTPGLg-hKICYIMMDLPV-LSNREAYIRGYGVDkle---qsKSFLICCQTIHhdkey---- 195  Paramecium te...
EEE28390      284 WVPYfsrpvklGLRDVVGTSLGRv-dQLVQFHVDFPWpLSNRDALFEVWAVDdfe---rnSQIAVKMTTLDhesps---- 355  Toxoplasma go...
EEF38297      200 WWPQisf-ppfKITSCKCLQKVQvgeHVSFLRVKVTWpLSAREAIVHYFLFEyl----kdGLVVVLVNSISdsesidks- 273  castor bean
XP_001749540  156 WLPSafs--lgVAESRVVYNLHRt-kLWTHMRVRLPWpFSNRCGDLFVDGVDcmeptearRQIVIMMNSVNddthlealr 232  Monosiga brev...
NP_001154608  187 WWPKltf-psfRVLEAKCLQKFRideQICLLRVKAPWpLTDREAVLQFFVFEyf----kdDLVIILLNSIE--------- 252  thale cress
XP_002182179  234 WVPKwrfpfklGISRSKKLAQRArldQVVQLTVDLPWpMNKREIVFWGFAEEdgm---anRNVGAKLQSVGegfd----- 305  Phaeodactylum...
XP_001007735  461 YVPF-------VEEGKLVKDIRRa-sKIGYACMDVPM-VSKRECYFYGTGYNlld---eiGSIPLVSKSIHsdpefc--- 525  Tetrahymena t...
XP_001429898  310 YVPF-------CVRSSMPKRIGKc-cKICDIQVYFPL-ISDRKAVFVGEGIDrln---inGTIVFLCKSVDnnpefl--- 374  Paramecium te...
XP_001026223 7853 WFPF-------CKVGKNLKTVDKa-cKVVYLKMDVPF-ISDREVFIHGIGVNrlh---kdGSIIIMARSIDkdiecq--- 7917 Tetrahymena t...
Feature 1                              # #### #                           # # # # # #       # ### 
EER02592      230 --vsasdmpIPARg---STTCDILKNSGATLTPMe----------------DGKTFLQIVMHIDPHIscVPNWLIDMAAR 288  Perkinsus mar...
XP_001443697  196 ----qalhqINTTq--vNCVQVEINFFAVEVTLIn----------------AGEFVMKSVANLDPKMkfIPQTVMNFLMK 253  Paramecium te...
EEE28390      356 -----prhrVPVTqp-aEGVERMCVDGNLVIIPRg----------------SNASFLRLLWHTNCRMh-VPMKMVEFVSK 412  Toxoplasma go...
EEF38297      274 -thgftrdgIPEA----KDVVRIDLVGGFAIQKVt----------------PERSYFRTIATVDLKLdfVPPTLLNFISR 332  castor bean
XP_001749540  233 qrfgrtdlaIPQDaadaGAVPLEVTHTAFLLTPAeina---------dmdrRSGTFVQFTARIDAKFdaLPACAINVGVK 303  Monosiga brev...
NP_001154608  253 ---------VESGsvaeVNAVRIDFVGGVAIQKVt----------------PEKSYIRFIAEVDIKLdlVPPSLINFMSR 307  thale cress
XP_002182179  306 ------nglVPSVd---RGVVRMDFEADFLFRPCpedhsaldktegkypegESKILLTFVMYCDPKVsfVPHSFMNFCTR 376  Phaeodactylum...
XP_001007735  526 ---rkidlqIPKTt---KYVRLEYKYYVFNIIPLg----------------PNKCYVKIVLNVDYKIplVPKSIQNWCAR 583  Tetrahymena t...
XP_001429898  375 ---klhnvdLSKDk--gKFVNLILNYYVFELTPLs----------------DNKCRVRAVTNSDPQCryVPKALVALVAR 433  Paramecium te...
XP_001026223 7918 ---ketgvdVPTAs---KCVRVDIPFFTFVFKPLs----------------ETKLQLYSVCNMDAHLklVPDSIINLVLR 7975 Tetrahymena t...
Feature 1         ###  ##  #       
EER02592      289 HFCYLMLKQVGPPAAAA 305  Perkinsus marinus ATCC 50983
XP_001443697  254 KIGKFMYERFCKLAQNI 270  Paramecium tetraurelia strain d4-2
EEE28390      413 IFSRGAFSAFQSACKAA 429  Toxoplasma gondii VEG
EEF38297      333 QLIGSGFRLYQKAVASV 349  castor bean
XP_001749540  304 NLAHLLIARMAEQARKV 320  Monosiga brevicollis MX1
NP_001154608  308 QLLGNGFKLFKKTIGSV 324  thale cress
XP_002182179  377 TAVGTVWRMILHVAEQV 393  Phaeodactylum tricornutum CCAP 1055/1
XP_001007735  584 KFSLYFFERIIKKATNF 600  Tetrahymena thermophila SB210
XP_001429898  434 KMASTLFEKMQKITQNF 450  Paramecium tetraurelia
XP_001026223 7976 KFAYFLFEKMIEQNKKF 7992 Tetrahymena thermophila SB210

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