Conserved Protein Domain Family
START_STARD9-like

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cd08874: START_STARD9-like 
C-terminal START domain of mammalian STARD9, and related domains; lipid binding
This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD9 (also known as KIAA1300), and related domains. The START domain family belongs to the SRPBCC (START/RHO_alpha_C /PITP /Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. Some members of this subfamily have N-terminal kinesin motor domains. STARD9 interacts with supervillin, a protein important for efficient cytokinesis, perhaps playing a role in coordinating microtubule motors with actin and myosin II functions at membranes. The human gene encoding STARD9 lies within a target region for LGMD2A, an autosomal recessive form of limb-girdle muscular dystrophy.
Statistics
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PSSM-Id: 176883
View PSSM: cd08874
Aligned: 3 rows
Threshold Bit Score: 358.456
Threshold Setting Gi: 72113738
Created: 30-Jul-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative lipid
Feature 1:putative lipid binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                ##      #            # #          #   #     #  ## ##  
XP_421162 4416 TTEVMAACSHNLRNLYTCQAAAGWKYQCTEkeVLVYYKVFpsatkHGFLGAGVIERPLAYVWGLVRdPGKRHLYDRSINT 4495 chicken
Q9P2P6    4410 MADVMAACSDNLHNLFSCQATAGWNYQGEEqaVQLYYKVFsp-trHGFLGAGVVSQPLSRVWAAVSdPTVWPLYYKPIQT 4488 human
XP_782132  307 ESIRAAGINVNVSENDQMQQTGGWSFHCLEkdVVILKKPKng-kyYSYLGKGIIKASPATVFKAIKnPRTRFTYDTMLKK 385  purple urchin
Feature 1                      # ####   #  # # #              #                 # #### #       
XP_421162 4496 ARIHKKITshiQLVYLVTDTSLcylQQPRDFCCITVEAKeknLSVLAIQSVYdasmPHPceDVVRGEILPSAWILEPDvv 4575 chicken
Q9P2P6    4489 ARLHQRVTnsiSLVYLVCNTTLcalKQPRDFCCVCVEAKeghLSVMAAQSVYdtsmPRPsrKMVRGEILPSAWILQPItv 4568 human
XP_782132  386 MNIVKTFSedlCVYHMVHEVPQllkKESRDFCVLQVCKAvgeRHIVACRSIEwkdcPEEg-SLVRAHMLPSGWVIEPV-- 462  purple urchin
Feature 1             # # # # # #        # ###   ##   ##  #        
XP_421162 4576 nGRDITRVIYMAQVRLFItvdlgaPAIPAQLLSSIAKRQPLVIARLAHFLAS 4627 chicken
Q9P2P6    4569 eGKEVTRVIYLAQVELGA------PGFPPQLLSSFIKRQPLVIARLASFLGR 4614 human
XP_782132  463 -GNQYSMVTYITQVALCG------KDVPAAFSQFLSVRVPLSIAYLRLFMEA 507  purple urchin

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