Conserved Protein Domain Family
START_STARD10-like

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cd08871: START_STARD10-like 
Lipid-binding START domain of mammalian STARD10 and related proteins
This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD10 (also known as CGI-52, PTCP-like, and SDCCAG28). The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD10 binds phophatidylcholine and phosphatidylethanolamine. This protein is widely expressed and is synthesized constitutively in many organs. It may function in the liver in the export of phospholipids into bile. It is concentrated in the sperm flagellum, and may play a role in energy metabolism. In the mammary gland it may participate in the enrichment of lipids in milk, and be a potential marker of differentiation. Its expression is induced in this gland during gestation and lactation. It is overexpressed in mammary tumors from Neu/ErbB2 transgenic mice, in several breast carcinoma cell lines, and in 35% of primary human breast cancers, and may cooperate with c-erbB receptor signaling in breast oncogenesis. It is a potential marker of disease outcome in breast cancer; loss of STARD10 expression in breast cancer strongly predicts an aggressive disease course. The lipid transfer activity of STRAD10 is downregulated by phosphorylation of its Ser284 by CK2 (casein kinase 2).
Statistics
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PSSM-Id: 176880
View PSSM: cd08871
Aligned: 24 rows
Threshold Bit Score: 293.779
Threshold Setting Gi: 67472807
Created: 30-Jul-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative lipid
Feature 1:putative lipid binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                    ##       #              # #                   #   # 
AAD34047      87 RESVQVPDDQDFRSFRSECEAev-gWNLTYSRag-vSVWVQAVem-drTLHKIKCRMECCD--------VPAETLYDVLH 155 human
XP_002158462   4 INEVRLSNDEDFEMFRTLATStd-eWIIKYNKnd-iKVYTKWTdd--sRIKLIKVSAMFEG--------VSLDCLYDVIH 71  green hydra
AAW25626       6 IGEVASDTAFLLKVVEEYLSGs--pWTQEYAKnd-vRVWSKGSen--eGIKCFKATALFKG--------VSGSELFDCIM 72  Schistosoma jap...
CAZ31071       6 LGEVGPPKDDDFHRFKNFVKDet-nWKRRHKKkn-vEVFTRSTlh--tNMKMIKVVAIFPD--------VSSHVIYDMLH 73  Schistosoma man...
XP_652951     18 NPKYPVPSLEDFMEFKKTIDDdd-gWKVKQDKng-tKVLFRDAen--eEILQVKLKTMALHd-------IPAEVLHDVVQ 86  Entamoeba histo...
XP_654479     13 NPDLPISTKADFEEFKGFFDQte-gWIESYKDeh-tQVHFKNPen-taEIQVKLVSDAMKD--------IPAQVIYECIH 81  Entamoeba histo...
XP_843896     12 GEKYRLQVLRDFRKFKELVLStn-aWTKQYSDsh-tLVETRPPedkstGINIVRVKREMPG--------VTCEDLYDTLH 81  Trypanosoma bru...
CAM40135      13 GTRYVLMTLPHFRKVRKLALSrdasWKTHYSDsq-lTVESKPPedastHLNIIRATRIMKK--------VPPLVLYNQLH 83  Leishmania braz...
CAJ02831      48 GRIYRLPSRADFYTFRTFADSld-gFALRYNRanevMVWEKKLsn--ePMHVIKVFGIFVKtkdnpsggATPGELYNLLQ 124 Leishmania major
XP_828713     30 GRRYRLPAKNDFLAFRNYADSle-gYSLRCNRpndtIVWSKKVkg--eSLNVVKVFSVYPG--------VDPQTMYDMLQ 98  Trypanosoma bru...
Feature 1            #  ## ##                  # ####  #  # # #                #                 
AAD34047     156 DIEYRKKWDSNVIETFDIARLTVNADVGYYSWRCPKp-LKNRDVITLRSWLPmg--aDYIIMNYSVKHPKYPPRK----- 227 human
XP_002158462  72 DPDYRKVWDKDMYDSYDVCKLNSNNVIGWYAAKLPPp-LMFRDWCLLRTWRKtn--qEFSIFNHSVQHMKIPVRK----- 143 green hydra
AAW25626      73 DSEYRKQWDKSMIESYEFCQVNPKSDIGYYSLRSPPg-LKNRDFVLQRTWEKfd--aYYVIACHSVFHKAVPVRK----- 144 Schistosoma jap...
CAZ31071      74 DNNYRSSWDNTMRESTEICRITWNCYIEHFGFRAPFa-FANRDFVLLRAWQPye--hEYIIFNRSVFHKKVPPRS----- 145 Schistosoma man...
XP_652951     87 DPAYRTEWDSSMKSERLVEQIDENTEIGYYSVKMPFt-IKNRDWVNMRSWWFnedksLFIIINHSVEHEKAPVEK----- 160 Entamoeba histo...
XP_654479     82 DPDYRKTWDDRMIEGFLIEQIDECNDIGYYSVAMPFi-ISNRDWVNRRSWWHnpemtEFIIFNFSHKHPLVPEKS----- 155 Entamoeba histo...
XP_843896     82 DAGYRATWDENMLEGKNIATLSPHNDIGYYAVKLPWp-LKNRDFCNLRSWMEft-ngEFVIFNHSVKHPNCPEKK----- 154 Trypanosoma bru...
CAM40135      84 DAQYRTTWDTNMLDGYNIVQLDKHNDIGYYAAKFPWp-LSNRDFCNMRSWMEft-ngEYMIFNHSEPHPDCPVKK----- 156 Leishmania braz...
CAJ02831     125 DPIFREQWDEYRQEAFRVMSLSANTDIGYYAAKSPMplVANRDFVNQRMWHEag-rdEYVIFNTSVPHSAVPPTYqkdah 203 Leishmania major
XP_828713     99 DGLYRVVWDTYRIEAFCIVQLSPNTDIGYYAAKSPAtgVTNRDFVNQRAWHSag-ngEFIIFNTSVPHRDVPTNYlkank 177 Trypanosoma bru...
Feature 1                 # #### #                 # # # # # #      # ### ###  ##  #             
AAD34047     228 -----DLVRAVSIQTGYLIQSTg------PKSCVITYLAQVDPKGsLPKWVVNKSSQFLAPKAMKKMYKACLKYpeWKQK 296 human
XP_002158462 144 -----MFVRSHSYVSGYYGEKIt------DTCTKITFVSQTDPKGkLPKWFVNTLATVMSPRIMKKLHKTSLAYtkWKSK 212 green hydra
AAW25626     145 -----QFIRALSHINAYIIRVLs------THSCEMTYVTNCDPRGkIPIWVINKATQFMAPRAIQILYKASTKYntWKKS 213 Schistosoma jap...
CAZ31071     146 -----EYVRALTFITGYVITALs------PVSCQLMYLTQNDPRGdIPSWAINLATTKVAPRLVKSLHRAALCYpgWKAQ 214 Schistosoma man...
XP_652951    161 -----DFIRAKSLKTGYVIEKT-------PEGTKLSFFSWNAWNGwIPNWCVNKATKTMVADCVEDLRKASAKYpeWKKA 228 Entamoeba histo...
XP_654479    156 -----GFVRAWSYKSGYYMKTT-------EKGTMFYYFGWNSWNGwIPAWCVNKATKTMVGGVIDSLMKQSAAYeeWKSK 223 Entamoeba histo...
XP_843896    155 -----QFVRARSIITGYLIQPFg------DGGCLLSYITCSDPCGsIPHSVINFTTTRIVPKVMNQLQKCALKYgeYFAK 223 Trypanosoma bru...
CAM40135     157 -----GFVRARSILTGFYIRPIp-----gESGTQLIYVTQSDPCGsIPHSVINYAMTKGARMILDNCEKYSERYpaYTEK 226 Leishmania braz...
CAJ02831     204 rnkhgPYIRAISKLTGYLIRPWknpksgeVEGASLTYITQTDPGGwIPVSLTNYIATKFAPNTMKNVAQALPKFrlWFKE 283 Leishmania major
XP_828713    178 -issdSVVRGFSKITGYLIRPWed---kgTKGCCLTYVTQCDVGGwIPTMVMNYVTTKASPNTVKTVRGAVAGFteWVPK 253 Trypanosoma bru...
Feature 1                        
AAD34047     297 HLPh---fKPWLHPEQ 309 human
XP_002158462 213 NNPh---sKPWLDKDI 225 green hydra
AAW25626     214 NHPd---rKPWLYPEQ 226 Schistosoma japonicum
CAZ31071     215 NRPe---fKPWRNPEQ 227 Schistosoma mansoni
XP_652951    229 NHPe---eKYWMKEGK 241 Entamoeba histolytica HM-1:IMSS
XP_654479    224 NKPe---dRPWLRLND 236 Entamoeba histolytica HM-1:IMSS
XP_843896    224 NGKcpreeLPWRTPKM 239 Trypanosoma brucei TREU927
CAM40135     227 TYSvd-hvYPWRTPKM 241 Leishmania braziliensis
CAJ02831     284 QLKagtytKDWDLTPE 299 Leishmania major
XP_828713    254 QSDy---qRTWTSDPD 266 Trypanosoma brucei TREU927

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