1LN1,1LN3


Conserved Protein Domain Family
START_STARD2_7-like

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cd08870: START_STARD2_7-like 
Click on image for an interactive view with Cn3D
Lipid-binding START domain of mammalian STARD2, -7, and related proteins
This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD2 (also known as phosphatidylcholine transfer protein/PC-TP), and STARD7 (also known as gestational trophoblastic tumor 1/GTT1). The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD2 is a cytosolic phosphatidycholine (PtdCho) transfer protein, which traffics PtdCho, the most common class of phospholipids in eukaryotes, between membranes. It represents a minimal START domain structure. STARD2 plays roles in hepatic cholesterol metabolism, in the development of atherosclerosis, and may also have a mitochondrial function. The gene encoding STARD7 is overexpressed in choriocarcinoma. STARD7 appears to be involved in the intracellular trafficking of PtdCho to mitochondria. STARD7 was shown to be surface active and to interact differentially with phospholipid monolayers. It showed a preference for phosphatidylserine, cholesterol, and phosphatidylglycerol.
Statistics
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PSSM-Id: 176879
View PSSM: cd08870
Aligned: 11 rows
Threshold Bit Score: 236.892
Threshold Setting Gi: 167526451
Created: 30-Jul-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
PtdCho binding
Conserved site includes 27 residues -Click on image for an interactive view with Cn3D
Feature 1:PtdCho binding site
Evidence:
  • Comment:phosphatidylcholine (PtdCho)
  • Comment:based on binding of human STARD2(PC-TP) to PtdCho
  • Structure:1LN3_A; human STARD2(PC-TP) binds palmitoyl-linoleoyl-PtdCho, contacts at 4A.
    View structure with Cn3D
  • Structure:1LN1_A; human STARD2(PC-TP) binds di-linoleoyl-PtdCho, contacts at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                      ##          #            # #           #   #     # 
1LN1_A          6 GSFSEEQFWEACAELQQPala--gadWQLLVETSG----ISIYRLLDkktGLYEYKVFGVLEDcSPTLLADIYMDsDYRK 79   human
1LN3_A          6 GSFSEEQFWEACAELQQPala--gadWQLLVETSG----ISIYRLLDkktGLYEYKVFGVLEDcSPTLLADIYXDsDYRK 79   human
NP_001046822  105 GLVTEGDLRELVGNLGVAareperegWQQVVAKGNddvsYRVWCDKPm-eGPPRYLSVTTYERcSTELLRDFYMDnEYRM 183  Japanese rice
ABK24392      126 AVVSDEDLENLLHMLQVKdkg---paWQQIMNRSTptmtYQAWRYEPe-tGPTAYCSRTVMEDvTPELMRDFFWDdDFRP 201  Sitka spruce
EAW71382      119 HHPPEPKAQTEGNEDSEGke----qrWEMVMDKKH----FKLWRRPItgtHLYQYRVFGTYTDvTPRQFFNVQLDtEYRK 190  human
XP_001747559  214 LHFCDQDFIDLFIRSRDLeac--idgWEYTLTVGE----CDVYRRKRagqSLYEYTAVGTFTDiNPKLFHDAYLD-MRFM 286  Monosiga brev...
XP_001609884   18 VEPFPPDLVDLVQQFKSGgnf---taWKWVRDYKLhpntLKLYSKPHvdsTLKNFLVHGEVDV-TKEKMIELIVQmTQRS 93   Babesia bovis...
BAB01397       82 TLVSDEDLKGLIQKLGERsed--aeiWEDVIKKSNprisYTAKCCKPtdgSPMKYLSTTVFEDcSPEVLRDFYMDnEYRK 159  thale cress
NP_568805     127 NTVTELDLRHLVQLVERKdgg---qaWIQMMDRFTpgmrYQAWLREPk-nGPTEYRSRTVFEDaTPVMLRDFFWDdEFRP 202  thale cress
XP_001785300  118 EVVTNEDLDKLMTLANGKdgg---peWQIFLDKSIhdlkYQAWRREPehdGPTEYKTRTVVEDtSPELMRDFFWDdEFRC 194  Physcomitrell...
NP_566722     119 DVVTEKDLEHLLHLLEAGnas---feWQSMMDKSTpnmsYQAWRHEPe-iGPVVYRSRTVFEDvTPDIVRDFFWDdEFRP 194  thale cress
Feature 1             #                   # # #        # #                                        
1LN1_A         80 QWDQYVKELYEQECNG---ETVVYWEVKYPFpMSNRDYVYLRQRRDldm-egrKIHVILARSTSmp-qLGERs-GVIRVK 153  human
1LN3_A         80 QWDQYVKELYEQECNG---ETVVYWEVKYPFpXSNRDYVYLRQRRDldx-egrKIHVILARSTSxp-qLGERs-GVIRVK 153  human
NP_001046822  184 EWDNTVIKHEQLQFDEnsgIEIGRTIKKFPL-LTPREYILAWRVWEgn----dKSFYCLVKECEh--pVAPR--QRKFVR 254  Japanese rice
ABK24392      202 RWDDMLTYFKTLEECPltgTMIVHWIRKFPFfCSDREYIIGRRIWEs-----gRTYFCVTKGVPy--pSVPRhsKPRRVD 274  Sitka spruce
EAW71382      191 KWDALVIKLEVIERDVvsgSEVLHWVTHFPYpMYSRDYVYVRRYSVdq---enNMMVLVSRAVEh--pSVPEspEFVRVR 265  human
XP_001747559  287 EEISQFTYDVDFVYGE---PGPVQCVTKFPFpLSDRDYVVYRESRYvalpngsRAYVVMMSGEDfadvRVKR--GRVRVK 361  Monosiga brev...
XP_001609884   94 KWDETYVEHQILHKSTk-gTDIMFSVSKYPFpLAKRTYVIKRSLYGsm----dDVVVLVSKVIPye-yTTKYk-WSTKVD 166  Babesia bovis...
BAB01397      160 QWDKTVVEHEQLQVDSnsgIEIGRTIKKFPL-LTPREYVLAWKLWEg-----kDKFYCFIKECDh--nMVPQ--QRKYVR 229  thale cress
NP_568805     203 TWDTMLSNSTTVEECPstgTMIVRWIRKFPFfCSDREYVIGRRIWNc-----gNSYYCVTKGVSv--pSIPPnnKQKRVD 275  thale cress
XP_001785300  195 HWDEMLIYTKTWEACEetgSMIVQWVRKFPFfCKDREYVIARRMWEt-----nNTYYAVTKGTQy--aPIPRqqAPRRVD 267  Physcomitrell...
NP_566722     195 KWDTMLAYFKTLEEDPktgTTIVHWIKKFPFfCSDREYIIGRRIWEs-----gRKYYAVTKGVPy--kALSKrdKPRRVE 267  thale cress
Feature 1          # # #                # # #              ###   #  ##  #       
1LN1_A        154 QYKQSLAIESD-----GKKGSKVFMYYFDNPGGQIPSWLINWAAKNGVPNFLKDMARACQNY 210  human
1LN3_A        154 QYKQSLAIESD-----GKKGSKVFXYYFDNPGGQIPSWLINWAAKNGVPNFLKDXARACQNY 210  human
NP_001046822  255 VQLLRSGWCIRk----IPGRDACRITVLHHEDNGMNIEMAKLAFAKGIWNYICKMNSALRRY 312  Japanese rice
ABK24392      275 LYHSSWRIRAVesrkgDGQMTAMEVMLFHNEDMGIPREIAKIGVRQGMWGAVKKVEPGVRAY 336  Sitka spruce
EAW71382      266 SYESQMVIRPHks--fDENGFDYLLTYSDNPQTVFPRYCVSWMVSSGMPDFLEKLHMATLKA 325  human
XP_001747559  362 DTLQCMVLEEQp---dDPLNPRMYVSAWENPEGSIPAWFVNYVGKFAIPAFMKELRNGTRRY 420  Monosiga brevicollis MX1
XP_001609884  167 DFESILMVRNHk---pGEEACEMLATYFENPKVILPNMYLNQIIETLVPRILEKLVIASKKF 225  Babesia bovis T2Bo
BAB01397      230 VSYFRSGWRIRkg-kcFLSGNACEIHMVHQEDAGLNVEMAKLAFSRGIWSYVCKMENALRKY 290  thale cress
NP_568805     276 LFYSSWCIRPVesrrdDGVTSACEVLLFHHEDMGIPREIAKLGVKRGMWGAVKKMEPGLRAY 337  thale cress
XP_001785300  268 TFFSSWRVRAVesakgDGQMTACEVLCFHAEDMGIQRDLAKLGIRQGMWGCVKKMMPGLNKY 329  Physcomitrella patens subsp. pa...
NP_566722     268 LYFSSWIINAVesrkgDGQMTACEVSLVHYEDMGIPKDVAKLGVRHGMWGAVKKLNSGLRAY 329  thale cress

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