2PSO


Conserved Protein Domain Family
START_RhoGAP

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cd08869: START_RhoGAP 
Click on image for an interactive view with Cn3D
C-terminal lipid-binding START domain of mammalian STARD8, -12, -13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD8 (also known as deleted in liver cancer 3/DLC3, and Arhgap38), STARD12 (also known as DLC-1, Arhgap7, and p122-RhoGAP), and STARD13 (also known as DLC-2, Arhgap37, and SDCCAG13). The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. Proteins belonging to this subfamily also have a RhoGAP domain. Some, including STARD12, -and -13, also have an N-terminal SAM (sterile alpha motif) domain; these have a SAM-RhoGAP-START domain organization. This subfamily is involved in cancer development. A large spectrum of cancers have dysregulated genes encoding these proteins. The precise function of the START domain in this subfamily is unclear.
Statistics
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PSSM-Id: 176878
View PSSM: cd08869
Aligned: 14 rows
Threshold Bit Score: 307.313
Threshold Setting Gi: 25151116
Created: 30-Jul-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative lipid
Conserved site includes 44 residues -Click on image for an interactive view with Cn3D
Feature 1:putative lipid binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                   ##         #            # #           #   #   #  ## ##
2PSO_A         32 TYLNHLIQGLQKEAKEK---FKGWVTCSStd--nTDLAFKKVGDGnPLKLWKASVEVEA-PPSVVLNRVLRERHLWDEDF 105  human
XP_001900728 1354 TYLLQKARELLKGHRDR---WKGWIVEGTvd--gVEISTKKSTDGhPLRFFRVWVDIEA-PPREILIRIVRERNVWDLQI 1427 agent of lymp...
Q96QB1       1323 HFLQDCVDGLFKEVKEK---FKGWVSYSTse--qAELSYKKVSEGpPLRLWRSVIEVPA-VPEEILKRLLKEQHLWDVDL 1396 human
XP_002154605  618 HHIDTCFSDLLQETSVNs-rSTKWDIHSEcd--eITISYRKVNDGyPLRVWRAVTEVQA-SPEEILKRIIKERHLWDDEI 693  green hydra
XP_394183     747 GYLYACTTALLKEAREK---SRGWVTVNNpadstVEMAYKKVGDGhPLRLWRVSTEVEA-PPNELLHRVLRERHIWDPQL 822  honey bee
XP_969885     562 EYLQECQMALLREVKER---NRGWIVVSGhn-prVEVSYKKVADGhPLRLWKVSAEVEA-PPLEVLHRIIRERHLWDPEL 636  red flour beetle
XP_002436242  262 RSVTRGADCALQEAREK---SKGWATVQHa---eVELAFKKLGDGlPLRLWRCAVEVEA-PPVELLTRILRERHVWDNTL 334  black-legged ...
ACI90382      473 SFINRCIVEMIRESCYTk--LKGWTSFGKnn--eLNLAFKKLDDGhPLGLWKCSIEISA-PPLEILNRLLNERNLWDDDF 547  Philodina ros...
XP_002120289 1085 SYVDRTVLQTMREEQRIsqnKGGWQNVPSsa--gSDLSCKKMHDGnPLRLWRCQVEVSGaTEEQLLERILHERHVWDDDL 1162 Ciona intesti...
XP_694618     829 ARLFLLTQKLLREARDK---SKGWTSCLSsd--hVDVAVKKVDDGyPLRLWRGTTEVDA-PQQEVFQRILREQSQWQRDL 902  zebrafish
Feature 1                           # ####  #  # # #                  #                 # #### #  
2PSO_A        106 VQWKVVETLDr-qTEIYQYVLNSMApHPSRDFVVLRTWKTDLPKg--MCTLVSLSVEhe-eAQLL-GGVRAVVMDSQYLI 180  human
XP_001900728 1428 INWRTVAVLNaenCDVFQYVINDTPsHPTRDATVVRLWHKDLKElrgGCVLVERSVHss-eTQML-GGISIAVLSSQFLV 1505 agent of lymp...
Q96QB1       1397 LDSKVIEILDs-qTEIYQYVQNSMApHPARDYVVLRTWRTNLPKg--ACALLLTSVDh--dRAPV-VGVRVNVLLSRYLI 1470 human
XP_002154605  694 LEWQVIDTLDd-cTDVFYYETQSIApSVKRDFVILRSWRYNLNGg--SCGVVMTSVKh--kNEPPtSGVRATLLAFRCLI 768  green hydra
XP_394183     823 LKYRLVAKLDt-nVEVFQYATGNMSpLPARDYCVLRSWRNDLPKg--ACVIVETSVEhpdaPVML-GGTRGIVLASRYLI 898  honey bee
XP_969885     637 HSAKIVSQIDk-nCEVFQYVRRKIVpLPNEEYCVVRTWRTDLPKd--SCLVIETSVEhq-dAVPIpNTVRGIVLASRYLI 712  red flour beetle
XP_002436242  335 LKWRHIAKLDk-qSEVIQYICSSMKpQAPRDFCVLRAWRTELAKg--SCALVELSVNhtdaTVLL-RGVRAVVLASRYLI 410  black-legged ...
ACI90382      548 QSGSVVEQLNr-hTHVYQYVINSMA-PLASRYFSTNVTNGNQRE---ACVLVCTSIEhpkgRCPP-TLVRAVTLASRYLI 621  Philodina ros...
XP_002120289 1163 IQWKVLKRPDe-rTQLFQTARAEMSpHPTRDYCVLRSWRRNVNSr-gASVIVETSTSn---PSML-GDVRGVILASRYVI 1236 Ciona intesti...
XP_694618     903 THSEVVETLDk-dVEVYHYTLQAAGaRPPLQHVLLRTWQLDSSTg--PMFVSSTSVQh--tAVAV-RGVQAQVFCSFFLI 976  zebrafish
Feature 1                   # # # # # #      # ###  ### ##  #       
2PSO_A        181 EPCg-SGKSRLTHICRIDLKGHsPEWYSKGFG-HLCAAEVARIRNSFQPL 228  human
XP_001900728 1506 EPI--AGRSRVTYITRTDLRGRsNIWYSKVYG-QLIARQLSRLRDSFKQF 1552 agent of lymphatic filariasis
Q96QB1       1471 EPCg-PGKSKLTYMCRVDLRGHmPEWYTKSFG-HLCAAEVVKIRDSFSNQ 1518 human
XP_002154605  769 EPIg-LGRSRLTSISRIDYRGTsSRYYNKVVSpRVMSSGVRKIRDSFNCG 817  green hydra
XP_394183     899 EPCg-SGKSRIMHLSRVDTKGRtPEWYNKSYG-HLAALHLSKIRNSFKHT 946  honey bee
XP_969885     713 EPCg-SGRSKLLHLSRVDSMGKtPEWYQKNYG-HICALFVANIVSSFYHV 760  red flour beetle
XP_002436242  411 EPCg-AGKSRVTHISRVDLRGRtPDWYHKVYG-SMCALLLIRLRDSFAQR 458  black-legged tick
ACI90382      622 QSNg-CGKSKVTHLSRIDLMGRsPEWYTKAYG-PILSRSMMKLRDSFVQL 669  Philodina roseola
XP_002120289 1237 EPTddPLTCQLTHVCRVDTKGRnPEWYNKAYG-HVVVQQLLRIRDSVRVM 1285 Ciona intestinalis
XP_694618     977 EPLg-SKKSRVTHLCRTDTRGRtPEWHHKVEG-HLVSSVLMAIRDSFRHK 1024 zebrafish

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