1EM2


Conserved Protein Domain Family
START_STARD1_3_like

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cd08868: START_STARD1_3_like 
Click on image for an interactive view with Cn3D
Cholesterol-binding START domain of mammalian STARD1, -3 and related proteins
This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD1 (also known as StAR) and STARD3 (also known as metastatic lymph node 64/MLN64). The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. This STARD1-like subfamily has a high affinity for cholesterol. STARD1/StAR can reduce macrophage lipid content and inflammatory status. It plays an essential role in steroidogenic tissues: transferring the steroid precursor, cholesterol, from the outer to the inner mitochondrial membrane, across the aqueous space. Mutations in the gene encoding STARD1/StAR can cause lipid congenital adrenal hyperplasia (CAH), an autosomal recessive disorder characterized by a steroid synthesis deficiency and an accumulation of cholesterol in the adrenal glands and the gonads. STARD3 may function in trafficking endosomal cholesterol to a cytosolic acceptor or membrane. In addition to having a cytoplasmic START cholesterol-binding domain, STARD3 also contains an N-terminal MENTAL cholesterol-binding and protein-protein interaction domain. The MENTAL domain contains transmembrane helices and anchors MLN64 to endosome membranes. The gene encoding STARD3 is overexpressed in about 25% of breast cancers.
Statistics
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PSSM-Id: 176877
View PSSM: cd08868
Aligned: 8 rows
Threshold Bit Score: 300.426
Threshold Setting Gi: 238659556
Created: 30-Jul-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative lipid
Conserved site includes 44 residues -Click on image for an interactive view with Cn3D
Feature 1:putative lipid binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                     ##        #                     # #          #   # 
1EM2_A        18 AQEREYIRQGKEATAVVDQILAQeenWKFEKNne-ygDTVYTIEVpf----------hgKTFILKTFLPCPAELVYQEVI 86  human
XP_002110119 184 SEHMELVKDLSITVNDLLSIDTD---WKIEKTtd--nLVVDSRNVqg----------igKVFRARIALDCKPADLFQVIC 248 Trichoplax adha...
BAF56876      67 LSIDEYKSQANESMANAWRIITLp-nWTVEKRgtvrgDVVESRKVeg----------fgKVYRFTGVVNCPARFLYEEFK 135 domestic silkworm
XP_974514    258 EQEENYKTLAAKAMQEAWDLLHKk-dWKLEKAsg--aDSVHTMTVpk----------vgKIFKLTAFLDVTPKFLLDELF 324 red flour beetle
XP_002427212 276 LPNCEFLQKGKNTLDTVWTILNDp-gWKLHKEnt-egDSIYLKNVkq----------wgNFFLLKTKVNMNAETLLLELF 343 human body louse
XP_001600687 267 EKIEECRKRAPSLLKSCHDLLTSs-dWKVEKItt-dgDVISSMMLpkp---------dgKIFKITGTIDVPAAKLINNLY 335 jewel wasp
CAZ30586     269 SHNLEAAVDVAALLHRTNSLQTEm--WNLYENei-wgDNSPSVNIkypfrsealpnypaKVYRLEGLLSVSPFHLFNDMV 345 Schistosoma man...
P49675        70 DQELAYLQQGEEAMQKALGILSNqegWKKESQqd-ngDKVMSKVVpd----------vgKVFRLEVVVDQPMERLYEELV 138 human
Feature 1             #  ## ##                  # ####    #  # # #                        #      
1EM2_A        87 lqpERXVLWNKTVTACQILQRVE-DNTLISYDVSAGAAGGVVSPRDFVNVRRIERRr----------dRYLSSGIATSHs 155 human
XP_002110119 249 ldcEHQSDWDSTVVQNKILKKLD-DQTDILYAIVAESGNGLVSKRDFLSIRHWEIEn----------gYYRTYSTSIKDd 317 Trichoplax adha...
BAF56876     136 nnlTKLPEWNPTILKCEIIKEIG-DGVDLSYQVTAGGGRGIITPRDFVILRRTALLsregrvvddnphGYISSGVSVQVp 214 domestic silkworm
XP_974514    325 yrvESLSQWNPAILESHKVQVID-EHTDISYQIAADGAAGVVSSRDFVNLRHWAYLe----------nRYVIACVGTEHp 393 red flour beetle
XP_002427212 344 kniNNYKNWNRNILECRKILVID-DHTDIIYQVTAPGGNGVVSSRDFITLRHWGVKe----------nCFLLSGISVSYp 412 human body louse
XP_001600687 336 dniESCTSWNKQVGEAKKIYVID-DNTDLVYQATKALGNGAIGARDFVVLRHRGKYe----------sFYISSGVSVNFs 404 jewel wasp
CAZ30586     346 invHETPSWNTTLTSVECIQALAsENIDIIHNMAKEAVGGLISARDFVLLRSWGIHnn---------nCYFICCTSVEHp 416 Schistosoma man...
P49675       139 ermEAMGEWNPNVKEIKVLQKIG-KDTFITHELAAEAAGNLVGPRDFVSVRCAKRRg----------sTCVLAGMATDFg 207 human
Feature 1                   # #### #                   # # # # # #      # ### ###  ##  #       
1EM2_A       156 -aKPPThKYVRGENGPGGXIVLKSas------nPRVCTFVWILNTDLKGRLPRYLIHQSLAATXFEFAFHLRQRISEL 226 human
XP_002110119 318 dlMPTHrSYVRGENKLSAWIIRPLqn------nANASHYTWLLHTDPKGWLPKNVVDFAIASVMIDFIKNLRRRIATV 389 Trichoplax adhaerens
BAF56876     215 -gYPPLkEMVRGHNKVGCWYLQPRtvqtpggkiEDQALFQWLMCCDLKGKIPQFVLDVAFATVMLDYIVHVRKFVAEA 291 domestic silkworm
XP_974514    394 -sLPKNdKYIRGENRAGCWVMQEDpn------nCNKCIFQWVLNTNLNGWIPQYIRDTAFIGVMFDYVKHLKQHIARL 464 red flour beetle
XP_002427212 413 -sFTSTkSYIRGENGPCCWALRPVpg------hLNKCYFDFLLNTNLNGWVPHYLVESAITFVLLEYSTCFKDYCKTL 483 human body louse
XP_001600687 405 -aVPSRkNFVRGENGIGCFATQSLan-----giTDRCQFIWLLNTNLKGWIPQKMVDMSTSIGLMEFMSALRLHANAM 476 jewel wasp
CAZ30586     417 -kCPPIpNYVRAEQVISACIFRPIpd------cPNQCNLVWFLCNDLKLGLPQRLLDRSLNSLLPTMMAGLIERSKLI 487 Schistosoma mansoni
P49675       208 -nMPEQkGVIRAEHGPTCMVLHPLag------sPSKTKLTWLLSIDLKGWLPKSIINQVLSQTQVDFANHLRKRLESH 278 human

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