1JSS,2R55


Conserved Protein Domain Family
START_STARD4_5_6-like

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cd08867: START_STARD4_5_6-like 
Click on image for an interactive view with Cn3D
Lipid-binding START domain of mammalian STARD4, -5, -6, and related proteins
This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD4, -5, and -6. The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD4 plays an important role in steroidogenesis, trafficking cholesterol into mitochondria. It specifically binds cholesterol, and demonstrates limited binding to another sterol, 7a-hydroxycholesterol. STARD4 and STARD5 are ubiquitously expressed, with highest levels in liver and kidney. STRAD5 functions in the kidney within the proximal tubule cells where it is associated with the Endoplasmic Reticulum (ER), and may participate in ER-associated cholesterol transport. It binds cholesterol and 25-hydroxycholesterol. Expression of the gene encoding STARD5 is increased by ER stress, and its mRNA and protein levels are elevated in a type I diabetic mouse model of human diabetic nephropathy. STARD6 is expressed in male germ cells of normal rats, and in the steroidogenic Leydig cells of perinatal hypothyroid testes. It may play a pivotal role in the steroidogenesis as well as in the spermatogenesis of normal rats. STARD6 has also been detected in the rat nervous system, and may participate in neurosteroid synthesis.
Statistics
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PSSM-Id: 176876
View PSSM: cd08867
Aligned: 5 rows
Threshold Bit Score: 330.193
Threshold Setting Gi: 20663956
Created: 30-Jul-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative lipid
Conserved site includes 44 residues -Click on image for an interactive view with Cn3D
Feature 1:putative lipid binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                   ##      #            # #          #   #        #  ## 
1JSS_A        21 SDVASISTKLQNTLIQYHSIEeDEWRVAKKAkdVTVWRKPSEEFnGYLYKAQGVMDDVVNNVIDHIRp---gPWRLDWDR 97  house mouse
2R55_A        22 SMAAQMSEAVAEKMLQYRRDT-AGWKICREGngVSVSWRPSVEFpGNLYRGEGIVYGTLEEVWDCVKpa-vgGLRVKWDE 99  human
AAL89655       1 MDFKAIAQQTAQEVLGYNRDT-SGWKVVKTSkkITVSSKASRKFhGNLYRVEGIIPESPAKLSDFLYq---tGDRITWDK 76  human
XP_002124134   7 ENFKVQAEKLEKEALEVINNI-NGWTYLKTVsnIKVYWKSSTYFtGHIYKFVVEVDALYSDVFDVMIppscsKEKLKWDK 85  Ciona intestinalis
XP_789877     75 MDFNEYADDVANRALDLYNDN-DWKVARSAKe-IKIMYKKSSEFdGHVYRAECTIDAPPEKIIHYILps-pkGLRGKWDK 151 purple urchin
Feature 1        ##                 # ####    #  # # #                #                  # #### #
1JSS_A        98 LMTSLDVLEHFEeNCCVMRYTTAGQLLnIISPREFVDFSYTVGYEE--GLLSCGVSVEWS--ETRP--EFVRGYNHPCGW 171 house mouse
2R55_A       100 NVTGFEIIQSITdTLCVSRTSTPSAAMkLISPRDFVDLVLVKRYEDg-TISSNATHVEHPlcPPKP--GFVRGFNHPCGC 176 human
AAL89655      77 SLQVYNMVHRIDsDTFICHTITQSFAVgSISPRDFIDLVYIKRYEGn-MNIISSKSVDFP--EYPPssNYIRGYNHPCGF 153 human
XP_002124134  86 SLKHYEQLRKVSeDISVGLIITPTAAMgLISKREFIDLYCCKTYDY--QWSNPGKSVDIP--GRAItpGCVRGLNYPGGY 161 Ciona intestinalis
XP_789877    152 NVKESDVIENINeNLIIARSATHSAAMgLIASRDFVDLITVRRYPDrgIVATSSRSVDRK--DRPPvdGFVRGVNYHGGT 229 purple urchin
Feature 1                     # # # # # #      # ### ###  ##  #     
1JSS_A       172 FCVPLkdsPSQSLLTGYIQTDLRGMIPQSAVDTAMASTLANFYSDLRKGLR 222 house mouse
2R55_A       177 FCEPLpgePTKTNLVTFFHTDLSGYLPQNVVDSFFPRSMTRFYANLQKAVK 227 human
AAL89655     154 VCSPMeenPAYSKLVMFVQTEMRGKLSPSIIEKTMPSNLVNFILNAKDGIK 204 human
XP_002124134 162 GVAENkrsPDKCFIELYVHTDVGGMIPRSLVEVALPLQQVSYVTHLVKEVK 212 Ciona intestinalis
XP_789877    230 FCSPVdgeSNKTRVVNIVQTDLCGMIPQSLVESALPNNLIEFFVDLDNSLK 280 purple urchin

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