Conserved Protein Domain Family
SRPBCC_10

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cd08865: SRPBCC_10 
Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins
Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.
Statistics
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PSSM-Id: 176874
View PSSM: cd08865
Aligned: 31 rows
Threshold Bit Score: 132.023
Threshold Setting Gi: 220914401
Created: 3-Jun-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        # # #        ### ##               #      # # # #                # #      # #    
ZP_04387542   18 VEQSVEIALPPKDVWEYMSVAeNWPNWENSmv-eCKQITd-GPMGVGSRWHgVSRILGKRLEWTSEFTEYd-PPRSSKst 94  Rhodococcus ery...
ZP_04385719    4 VTRKFTAEVPIEKAAAFLRDFaNAPTWDPGte-iCTQISd-GPVGVGTQWHnVSKLFGVTTELTYTLVTDe-LNHVVLeg 80  Rhodococcus ery...
ZP_00996196   19 IVREFEVPCPQDAAVAYLADFaHAVEWDPGtvscVRNGDpsEPALPGATWTnTSKVLGRETELQYTLVTLq-PDHVVLeg 97  Janibacter sp. ...
ZP_01102721    4 LKETIRVQRPVEECFDYTADFrTTPEWDATaf-kARKISd-GPVGLGTQFKvRCSLPLGSIELLYTITEFeaPNMVTLqa 81  Congregibacter ...
YP_704192      4 VSRTFTVAAPLEKVVAYLRDFaNTEAWDPGtd-tCEQTTl-GPVAVGTEWHnVSSFFGRTTELTYRMTRDd-PDHVVFeg 80  Rhodococcus sp....
YP_832741      4 VAGTVSSPLGAEEAFNYLSAFeHTAEWDPGtp-vVKKLSe-GPVAVGHRYHaEAEFRGKRQTLIYEVVEL--TGNHIKlr 79  Arthrobacter sp...
YP_951002      4 VTRTFTVTPPPDLVVGYLKDFeHAQQWDPGtr-sCERIDs-GPVAEGAYWHsVSKMLGITSELTYKLEEL--TDRRVVfv 79  Mycobacterium v...
YP_002486502   4 VAGSVETKLSAEKAFAFLSEFeNTSKWDPGtp-vMDKITp-GPVAVGHKYHaEAEFRGKRQKLIYEVIEL--TGSHIKlr 79  Arthrobacter ch...
ZP_05094678    4 LREVITVKRPVDEAFAYVADFtTTTEWDATal-kAVKVTp-GTIAVGTRFLvTCAMPVGSIDIEYTVAALeiPNRIVLsg 81  marine gamma pr...
ZP_04959344    4 LHEEAVVPRSARECFRYVADFrTTVEWDATav-lACKTSp-GPVAKGTEFEvHCKAGPTTLKLTYEIIEYe-PWHCLVlr 80  gamma proteobac...
Feature 1                   ## # #      # # # #                ##### ### ###  #      
ZP_04387542   95 svespvsfsqTTTCEEVGd-GTRVTYRLDSEsglggVFGKMADPi-VTKAFSRTVRVSLENLADILVH 160 Rhodococcus erythropolis SK121
ZP_04385719   81 knkt-atstdDITLTSVGpnSTEIEYHANVEf---nGAAKIASPllKAGFEAKVAPETVKKMTDALEA 144 Rhodococcus erythropolis SK121
ZP_00996196   98 snnt-adstdDIRVTSLDggRSRIRYEATITf---kAVARLADPl-MGLVFRKIADDTVRDMTAALTR 160 Janibacter sp. HTCC2649
ZP_01102721   82 eswl-fsavdTIYFAEDDg-QTRIDYHADFSy---kMPLAALEGv-LKSGMVRMGKSALRGLKRALDD 143 Congregibacter litoralis KT71
YP_704192     81 rngt-aatsdDLAFEKVDdaSTSITYRARLEf---tGLARFADPv-ARLAFEVLAAKTVTQMTGVLEA 143 Rhodococcus sp. RHA1
YP_832741     80 genktvisedSIDVSPDGt-GCTVQYTAEFQl---kGALRLIEPf-MKPAFMSLRDPAMNGLKSALDA 142 Arthrobacter sp. FB24
YP_951002     80 genqssravdIITVQAQGs-GSVVSYQADLEm---yGTAKLLNPv-IKLVCEKRAGDTERQMATVLNK 142 Mycobacterium vanbaalenii P...
YP_002486502  80 genktvvsfdSIDVSPNGa-GSVVKYTAEFSi---kGPAKIIQPl-LKPLFMQLRDPALKGLRDTLNS 142 Arthrobacter chlorophenolic...
ZP_05094678   82 kskl-fdiedTITFATVSg-GTKINYQAEFKf---gPLVGSLSGm-MQSGLDKMGRESLAGLKKALNN 143 marine gamma proteobacteriu...
ZP_04959344   81 grgrlfdvtdTILFTERDd-GTHISYTAEFQf---sGALSPLLSa-MEPGLHSMGKTSVEGLAQALTD 143 gamma proteobacterium NOR51-B

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