Conserved Protein Domain Family
SRPBCC_DUF3074

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cd08864: SRPBCC_DUF3074 
DUF3074, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily
Uncharacterized family of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.
Statistics
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PSSM-Id: 176873
View PSSM: cd08864
Aligned: 11 rows
Threshold Bit Score: 183.773
Threshold Setting Gi: 74625860
Created: 23-Nov-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
Q9USQ8        47 KWKHLGNHd-------------gVALYEKAPa------------------yTGHTWYGRVSKHTRSLKTFKKg------- 88  fission yeast
XP_001273232  57 TFEVDRKLrpspp------atanVQLWRRTLrpapg----------aassrKDEFWACRKSIHEDAVVEGSAsfde---- 116 Aspergillus cla...
Q0U917        90 SWGKPVKLgake-------tatgMSVYKMAGh------------------dRHGAWFARSSVHEGLGFTKWKec------ 138 Phaeosphaeria n...
XP_001398807 116 QWSKPIKVtntrd------nplqIPIYKLHGa------------------dGKGHWFGRRSVHEGLGFERWReklsg--- 168 Aspergillus nig...
Q6BPL9        31 TWKEDKKYtyklnk---lnsdinVQTYHNDRl-------------------NDDYWSARVSALKEVSFNDRKeyfsklee 88  Debaryomyces ha...
XP_361919     58 FKHKSRKTpags--------tapVSVSTRSIpkavldrihrenpsvdrrgvKSETWVCRRSVHEDLSIRGTAswae---- 125 Magnaporthe gri...
XP_001538797  68 SFTTDRNLydspp------sstpVQISSGTVkytplas------knpaaaqKEDKWFARRTVLDNRTTTGNAsfqe---- 131 Ajellomyces cap...
XP_001385517  31 TWAKDKQFlymlpk---qkrnigVQTYHANSl-------------------NGVHWSARVSDFKDFDSTAKSryfkllqk 88  Pichia stipitis...
XP_001481944  30 TWKKSKLYnydlvs----gkkvaVQTYTKTI--------------------NNDYWCARNSSLEELKDEKKQvyqnllky 85  Pichia guillier...
XP_001646163  37 NWKKGKCYkfktnklikdkkdisVQTYNKHI--------------------DSDFWMSRVSHHKIDKDTYYKivyylngs 96  Vanderwaltozyma...
XP_001524093  77 QWNEGKTFyks----------snYPVYSKHNe------------------vDGDFWCSRETVLKNINVERLRkaii---- 124 Lodderomyces el...
Feature 1                                                                              # # #     
Q9USQ8        89 ------------LLYEHIKKEA-----------DYDPLVF--------SAHQLETIIEDEi-----EIWMYKYKTPWF-- 130 fission yeast
XP_001273232 117 --------fragLRDNHAENER-----------AYTPSVAaln---rlLDWPIEPEIDGWerv-vmQVNLITHKFHPSvl 173 Aspergillus cla...
Q0U917       139 -----------mQKEFPESLEVqgg-----pgeGNVRGIGgd-----qRLEQMNVDGIGKl-----EVYQLSAQFPGP-- 190 Phaeosphaeria n...
XP_001398807 169 -------emgetLRRNQERIRKgkm------pdQAVRGIGaer--lveGIEVRAGDNEGDgvigrvQVFHVSAQFPKP-- 231 Aspergillus nig...
Q6BPL9        89 ----yivgsmncLEKTHTEYEK-----------QYIHELVd------yELKPITLKPNKDfdt-ftYLARLEYKFPFP-- 144 Debaryomyces ha...
XP_361919    126 --------frdcLKDRHAETEKaftptmvahqtVQEHLVVr-------DMEPVSVDGLRYgdf-tcATEGVRHKVAPCi- 188 Magnaporthe gri...
XP_001538797 132 --------fvegLKDNHLMNEM-----------EYEPNITavedvakwDCSGVEVEGGWSgv--gaSLSLVTHTFQPAsv 190 Ajellomyces cap...
XP_001385517  89 ----yilgsftnNDLTHTHYEK-----------EYIHELYdy-----dINKFDTPDNESAs-----YLVQLFYKFQFP-- 141 Pichia stipitis...
XP_001481944  86 -----ivgssvdQNKTHTEYET-----------KYVDEIYd------yKLETVSLKNSDEna--itYKGQMYYKFQFP-- 139 Pichia guillier...
XP_001646163  97 kkdpktgkwvmkDRAFRSKMEK-----------EYIEVLN--------KFEILEQTDSGW------VLVNLEYELGKP-- 149 Vanderwaltozyma...
XP_001524093 125 --------gtteQGFTHSDYEP-----------HYVHEIS--------EMQVRNLQQYKDgw---sYTIHAQYNFGFP-- 172 Lodderomyces el...
Feature 1            ### ##      #                 # # # #                        # #  # #   ## #
Q9USQ8       131 FRNRVYRQLVV-----SVMLDp------------DSFIVLQTPVTYPGss------------sgGGNGVVALYDSVDFVS 181 fission yeast
XP_001273232 174 ISPRTFISLLV-----SADLPdp---------vaKGFVTVQIPLTADPvetipralrekiaasaPRNAIFASYASVEQVL 239 Aspergillus cla...
Q0U917       191 TSPREFITLLI-----TSETCltdask-vgnavpRHYMVVSIPVSHPDap-------------pRNGMVRGYYESIEMIS 251 Phaeosphaeria n...
XP_001398807 232 TTARDFVSLIV-----SWDESegdeerkkregkgREWMMVSRPCEHDEvp-------------pVPGYIRGMYESVEFIR 293 Aspergillus nig...
Q6BPL9       145 LKRRVFFELIHi---cKSRTE-------------SLSYVISLAIDPKFfq------------seSSRMVNARYTSVEKIF 196 Debaryomyces ha...
XP_361919    189 LQDRVFFVLQIt----CSVLDeena-----ttaaHEFLVVNIPMADHPdsld--------pqalYRGATLGAYASVERIR 251 Magnaporthe gri...
XP_001538797 191 ISPRVFLAMVI-----TAFTPpeppa----sttpSVFINIQLPIHVSAippa---------lplPKNAVLGKYVSVEMVR 252 Ajellomyces cap...
XP_001385517 142 LKKRVFYEYVHv---fKEDNS-------------NDAYVVSLPISPKLlek----------sefNKEYVVGRYTSIEKIS 195 Pichia stipitis...
XP_001481944 140 LQRRIFHELVHi---vKAKDD-------------SEAYVITLALDPSLfa------------nkEPSFVPARYTSIEKIA 191 Pichia guillier...
XP_001646163 150 LATREFNEWVYpiepyKSKSSk-----------lETSMIVCLVANRPLkes-----------tiHENHTKAYYASVEKLE 207 Vanderwaltozyma...
XP_001524093 173 LSKRTFNELIHi----YIDAAk------------QWALIVSLPIKGAL----------------YEHSVLGEYVSLEELK 220 Lodderomyces el...
Feature 1         #                     # # # #         #####  ### ###   #         
Q9USQ8       182 KKLDgd----------gkEEGVLWICAVRNDYGSm----FSGLFSDTTFTKSLVRQVKLYNEWLNR 233 fission yeast
XP_001273232 240 SLPFavrsnsdarssrkyVAQVEWTMATTSDAGGaiprwVQQSWTLGGVPRAITADVGLFIKWTGH 305 Aspergillus clavatus NRRL 1
Q0U917       252 EIPLagae-------dpeSNPVQWTMVTRSDPGGg----IPRFMVERNVPSSIVQDAVKFLDWACA 306 Phaeosphaeria nodorum SN15
XP_001398807 294 EIPVenkp-------egaMNPVEWVMVTRSDPGGn----IPRWMVEKGTPKSICTDAVKFLNWACR 348 Aspergillus niger CBS 513.88
Q6BPL9       197 YGNS--------------TDDLEWKMATCSTPGGs----IPGWLSKLSINSAIAKDVPSFLNWSDS 244 Debaryomyces hansenii
XP_361919    252 ILPAgh----------edAGKIEWIMATASDAKGi----LPRFAQDLAVPDQIVKDVPLFFDWIDS 303 Magnaporthe grisea 70-15
XP_001538797 253 ILTDade--------aagPGKIEWRMATSSQAGGw----IPRFLQHSSIPNAIAKDVGLFLKWVDE 306 Ajellomyces capsulatus NAm1
XP_001385517 196 YDAE--------------SNDLKWIMCTCSTPGGs----IPDWLTNMTINGAIAKDVPSFLNWVDT 243 Pichia stipitis CBS 6054
XP_001481944 192 YDED--------------TNKLVWSMATCSSPGGs----VPDWMTKMGLPPAVAKDVPHFLNWVAS 239 Pichia guilliermondii ATCC 6260
XP_001646163 208 YDYE--------------KEELIWTMCTTSDAGGn----VPKFLQNATIAKTVAKDIPYLFDYILK 255 Vanderwaltozyma polyspora DSM...
XP_001524093 221 WNDN--------------NDSAEWLVATTSTAGGn----VPDWATKWSLAGALAKDVPNVVDLIAS 268 Lodderomyces elongisporus NRR...

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