2FFS


Conserved Protein Domain Family
SRPBCC_DUF1857

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cd08863: SRPBCC_DUF1857 
Click on image for an interactive view with Cn3D
DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily
Uncharacterized family of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.
Statistics
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PSSM-Id: 176872
View PSSM: cd08863
Aligned: 18 rows
Threshold Bit Score: 136.693
Threshold Setting Gi: 121739923
Created: 23-Nov-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 37 residues -Click on image for an interactive view with Cn3D
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         # # #                 ### ##                #                 # # # #          
2FFS_A         2 QFEHLVQVNDrtlvdlpvLDRLQLWEGLVCRAREPQYFVvg-lERFEILVddg--------drLHRRLYLpg-------- 64  Pseudomonas aer...
Q0CS65        10 NIAYSVPINKdps--qptLTLEEFWRGLHRGSEKPQLFAey-vADTEVLPns----------kSANEFQRkl-------- 68  Aspergillus ter...
Q1DYD1         5 NMSYTAPINQkgr---rsLTASQIWECIERKVRNAEEFVsa-iINTEILSesa--------teVTRRVTFaphgh----p 68  Coccidioides im...
Q2HI62         5 NFAYTAPINPpga--spvLTPAQVWTGLQYKVRRAEKFVpv-iTACEVISeelpasradgqhvITRRATFaegag----p 77  Chaetomium glob...
Q0USQ7         5 HLAYTAPINPlst--tpvLTHAQVWAGLQRKIRFAQEFVpv-iASCSVLSeed--------gvVTRDVVFkpgv------ 67  Phaeosphaeria n...
XP_001273336   5 NISYTEPVNPpdps-iqkLTSKQVWNGLVLKIRRPQEFIpa-iDECRVVEerdn------gsyILREAHVaanler--sp 74  Aspergillus cla...
XP_001262643   7 NIAFTSPINSpgv--dpiLTRSQIWNGLLLKIRSAETFVpaaiQSTAVLSesvde---vgnpvTIREVVFrqd------- 74  Neosartorya fis...
XP_367491      5 HLAATAPINPpga--kpvLSREQVWRALQIKVREPSLFVpv-iTSCAVVSekg--------nvVNREVQFksglg----- 68  Magnaporthe gri...
YP_001019649   2 RYEHLLQVTDpadprvppMSRAELWRGLLVRVESPQQFPlg-pDRCEARAgah-------areRRRSVHFga-------- 65  Methylibium pet...
XP_750864     11 NISFTTPANPpsc--epkLTAKDLWTGIARVADAPQEYApy-vSKCEVLSrng--------haLERKLTMangavhksdg 79  Aspergillus fum...
Feature 1               # #       # #           ## # #            # # # #              ##### ### 
2FFS_A        65 ---lVVEDEVVLkapdSAHYSIKpsaevaGGSLDXTIEepe---pgSLFVRFAYCTRylqpl---gdelpYDAFVKQAYI 135 Pseudomonas aer...
Q0CS65        69 ---iMANGAVHTa--kGVELLQDvr--naDGLLDDGPD--------ALYLTAVYELHvpdvepgserakeIEREYAQLAL 133 Aspergillus ter...
Q1DYD1        69 agaaEAVETCRMykpcRVDFVAAd-----GSTITNAVSvgpg-gdeEFYYTYIFEWHhpeiaegtpeasaQRIADWKTTK 142 Coccidioides im...
Q2HI62        78 kgggTIVEVCRLyapcRIDFGQEd-----GTTVGNYVSvgl---agELMMTYVFEWRvegvvegserareLEGGYVKMAK 149 Chaetomium glob...
Q0USQ7        68 gpkeKAREVVRGfgtsWVDFEQEd-----GSVVKNVISdga---dgALYMTYAFEFRfpdlregsaeaeaQREKLKGTSK 139 Phaeosphaeria n...
XP_001273336  75 magkYVREECRLheptWTHFTLPd-----GSEVQNIVSvgp---dqALYLTYTYKWRlsdieagtseakkAEEDHLEIAK 146 Aspergillus cla...
XP_001262643  75 --qrKVKETVTAhkdsRVDFVQPd-----GSTISNIVSega---egELYMTYVFEWRhpgase--eelaaLRDREKMMSK 142 Neosartorya fis...
XP_367491     69 lpegKISEACTNyapaKVHFKMDt-----GDEVENIVGqgpsddenDLWLTYAFDWVike--------gaDTSQHGKMAK 135 Magnaporthe gri...
YP_001019649  66 ---lRFEDTVQLepeqRIVFTPEphegaaPVRLTVTIEepa---pgALFLRFVYETDdagsa----eekaLQGYRQQAWL 135 Methylibium pet...
XP_750864     80 eimyQDVEARTKdtgaKTTFLLSy-----HDTAAVSPEst----diSFTVIYELKLTgiepgs--peaerIQAEYPELTR 148 Aspergillus fum...
Feature 1        ###  #      
2FFS_A       136 AXDVETIATIRD 147 Pseudomonas aeruginosa PAO1
Q0CS65       134 GAARTVVETIRR 145 Aspergillus terreus NIH2624
Q1DYD1       143 LAVEATIDTMHR 154 Coccidioides immitis RS
Q2HI62       150 MAVEGSIDTIRK 161 Chaetomium globosum CBS 148.51
Q0USQ7       140 MAVEKSIETIRQ 151 Phaeosphaeria nodorum SN15
XP_001273336 147 TSVQGTLKAMRV 158 Aspergillus clavatus NRRL 1
XP_001262643 143 GAVEGTISAMRE 154 Neosartorya fischeri NRRL 181
XP_367491    136 NAVAGTITVMRK 147 Magnaporthe grisea 70-15
YP_001019649 136 ELDRDMLRTLRE 147 Methylibium petroleiphilum PM1
XP_750864    149 KACTSTVEQIRE 160 Aspergillus fumigatus Af293

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