2B79


Conserved Protein Domain Family
SRPBCC_Smu440-like

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cd08862: SRPBCC_Smu440-like 
Click on image for an interactive view with Cn3D
Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins
This family includes the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of Streptococcus mutans Smu.440 and related proteins. This domain belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. Streptococcus mutans is a dental pathogen, and the leading cause of dental caries. In this pathogen, the gene encoding Smu.440 is in the same operon as the gene encoding SMU.441, a member of the MarR protein family of transcriptional regulators involved in multiple antibiotic resistance. It has been suggested that SMU.440 is involved in polyketide-like antibiotic resistance.
Statistics
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PSSM-Id: 176871
View PSSM: cd08862
Aligned: 16 rows
Threshold Bit Score: 115.53
Threshold Setting Gi: 126732066
Created: 10-Mar-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 37 residues -Click on image for an interactive view with Cn3D
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          # # #        ### ##              #                     # # # #        # #     
2B79_A         7 MKFSFELAVNTKKEDAWTYYSQVNQWFVWEgDLEQISLEGef------------ttGQKGKMKMed-mPELAFTLVEvr- 72  Streptococcus m...
EDK28818       4 VIFEERICIEASPQDIYSLYVDVENWNQWDkEVVYSRLLGaf------------evGVKGVIKPtn-gPKSKIVITDat- 69  Vibrionales bac...
ZP_00994747    1 MEQHVTVDIAATPERVWEVMTDVERWPEWTdTVTSVTRLDegp----------lavGSKARVEQpk-lPPTEYTVTEve- 68  Janibacter sp. ...
NP_962030     23 MFTEDSVEIDAPPRLVWDVFTDVERWPEWTaSVTSLTGLDgpa----------lavGRRFAIKQpg-mAKLVWQVTEli- 90  Mycobacterium a...
YP_001510927   1 MYYETSVTIDATSDEVWAVIRDVERWPTWTpTMTTVDMAArpaavgssgadgelrdGSVVRIRQpr-lPAAEWTVTDlt- 78  Frankia sp. EAN...
ZP_04746999    1 MRYIREEIVHAPAARVWELLVDVEGWPAWTkSMREIERLEtgp----------lavGSRYRVTQpk-gRPMVWTVTKlq- 68  Mycobacterium k...
ZP_02382082    2 WTCEKSIDIDATPERIWNLFRDVTGWPRWNnGIEQIEIHGpf------------adGTMFTMKIpd-aDSFTSVLLEvr- 67  Burkholderia ub...
YP_001866578   1 MKFSNTVTTFATPERIWAIWTDVDNWSVWDtEVCDSYLESpf------------klNAVGKLTPkt-gTTSKFTISQfsp 67  Nostoc punctifo...
YP_001633899   4 YEIAATTVTTAPPERVLAVLDDFGNWPRWMpSLERVRIELppne--------hprqGYRFKLHGl--lVHADMEVIDytp 73  Chloroflexus au...
ZP_01747868   16 VAARADILIDAPASAVWAVLSDIQSWPAWFrNVEWISAHIpp------------vpGTAFEMRAsgqtVRARLQVVDa-- 81  Sagittula stell...
Feature 1              # #         ## # #           # # # #            ##### ### ###  #      
2B79_A        73 --enQCFSDLTAtpfgNVLFEHEILENPd--GTISLRHSVSLTDSdtte-ealaFLKQIFADVPESVGKLKQILET 143 Streptococcus mutans
EDK28818      70 --pnKSFTVMSKlpfcRLSFEHQLEAKG---EITEVTHRVKFSGLtsfl-fgkvVGKKIYDGLPSSLEGLKKRAEN 139 Vibrionales bacteri...
ZP_00994747   69 --pgRSFTWVAKgpgvLTMARHSVEAQSg--GGTRALLSVEQTGLlgvvmgrlfFKGLTDRYLALEAAGLKARSEG 140 Janibacter sp. HTCC...
NP_962030     91 --pgASWTWVQRspgaRVAATHHVSARPg--GGTLVRQQLDQRGAlgal-vgrlMAKKTKRFLALEARGLKARAEQ 161 Mycobacterium avium...
YP_001510927  79 --pgSGFSWISRatgmTTVADHRIMPAAe-dGKVTVRLSLRQSGPlapv-valfMARLVRRYVDTEAQGLRQHCEQ 150 Frankia sp. EAN1pec
ZP_04746999   69 --pmRTFTWVATqpglSVEAVHRIDEDG---DGVRTTLELIMTGPlawl-agrtAGSRVRSYVDMESDGLKRAAES 138 Mycobacterium kansa...
ZP_02382082   68 --enASFVDETIidgtRVVVRHEISAMPs--GNVRVTYGTEITGPna-----deLGPVVTGDFEDVLKALKSLAEG 134 Burkholderia ubonen...
YP_001866578  68 -gksYTFTIQLPfc-kLNVYRYLNIHAGstsFTHEVSFKGALAFLfg-----wfLGKKFKKVLPRVMENIREIAEA 136 Nostoc punctiforme ...
YP_001633899  74 lsraTRFRISFPp--fQGVNRCRLIPLGdgrYRIERLDQLELPDLvahl-idstQRKRFEKLAMEFLQALRREVEQ 146 Chloroflexus aurant...
ZP_01747868   82 ---tHQLGWTGTalfvSTGHLVTLEDRGk-aTHVHATASYRGAWPlal---skqAKRHAKALLIEGLADLKAASEG 150 Sagittula stellata ...

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