Conserved Protein Domain Family
OtcD1_ARO-CYC_like

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cd08861: OtcD1_ARO-CYC_like 
N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus OtcD1 and related domains
This family includes the N- and C- terminal aromatase/cyclase (ARO/CYC) domains of Streptomyces rimosus OtcD1 and related domains. It belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. ARO/CYC domains participate in the diversification of aromatic polyketides by promoting polyketide cyclization. They occur in two architectural forms, didomain and monodomain. Didomain aromatase/cyclases (ARO/CYCs), contain two ARO/CYC domains, and are associated with C7-C12 first ring cyclized polyketides. Streptomyces rimosus OtcD1 is a didomain ARO/CYC. The polyketide Oxytetracycline (OTC) is a broad spectrum antibiotic made by Streptomyces rimosus. The gene encoding OtcD1 is part of oxytetracycline (OTC) gene cluster. Disruption of this gene results in the production of novel polyketides having shorter chain lengths (by up to 10 carbons) than OTC. Monodomain ARO/CYCs have a single ARO/CYC domain, and are often associated with C9-C14 first ring cyclizations, these latter domains belong to a different subfamily in the SRPBCC superfamily.
Statistics
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PSSM-Id: 176870
View PSSM: cd08861
Aligned: 43 rows
Threshold Bit Score: 91.6147
Threshold Setting Gi: 169629366
Created: 4-Jun-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        # # #         ### ##                   #        # # # #        # #              
AAL24453       9 TVHEIEVRA-PAEAVFDLVAGASRWPV---HFPps--vHVERLEg---DDRQERLRiWATA-NDEVKSW-TSRRELdrag 77  Streptomyces pu...
P41178       158 FTDTCTIDG-AAKDVFDFVNEADRWPE---RLP-----HVATVRfeepAPGLQILEmDTRAkDGSVHTT-KSYRVAld-t 226 Streptomyces ci...
NP_625570      5 VLHALADGL-APADVYARISDFRRYPEysdTFR-----EVRVEPp---LPDGTTVSdWTVEfRGGLMRW-RERDTYspet 74  Streptomyces co...
AAP85360      67 FADTETVSG-PPEEVYAFLYDAAKWPE---RIP-----HVAHVEvredVLGLQHLRmDTRApDGSVHTT-VSGRVCep-g 135 Streptomyces gr...
YP_276430      4 VNTSLNLGSlELERVWSTLCEFQRYPE---FMKdv--lDVTIEQ----RTGNEIIStWRVLlNGSELTW-TERDLLlp-d 72  Pseudomonas syr...
YP_483228    161 LHDDVRVDG-PADRVYDFLYAVDRWPD---RLP-----HVTRVDvqqdEPDVQLVEiDTAErRGGVLTT-RTARVGrp-p 229 Frankia sp. CcI3
YP_001510016   4 VELDAVVRGaLATDVFDEVLRWERYPD---LAP-----HVRATTvhatLPAPDCSSsWELHfRSGLLRW-TESDGFhrdd 74  Frankia sp. EAN...
YP_001680511  21 VEESLWIRG-TVGDVYALASRMEDYPL---FMRdv--rAVRIVE----RGDGFTLTdWETDvDGRSFRW-RERDEFypde 89  Heliobacterium ...
YP_001703015   3 TAQLIVDSSsHPDEAYRAIAQFEEYPQ---YVEdissiTVRQDDpsalVPETTYSD-WEVIfRNGPLRW-TEVDYHnpad 77  Mycobacterium a...
ACR15127      13 VVNSVVIGV-PAERLWRSCTDIERWPS---IFPtt--rEVRRTE----VGANEVVM-DMVVsNELGENTvRSHRRYrpeq 81  Streptomyces sp...
Feature 1          # #               ## # #         # # # #                       ##### ### ###  
AAL24453      78 lRVTFRQEesraPVRSMSGEWLLEPLGd---KGTRVRFTHAFTAvddap-----------enveWIRRAIDTNTGSELEA 143 Streptomyces pu...
P41178       227 rKIAYKQVtlpaLMTLHTGVWTFTRRPghhrGELAAHRLHQHANiakip----------rragqVADARDYVHSALSTNS 296 Streptomyces ci...
NP_625570     75 ySIAFEQVs--gDFQTFEGSWRCEARD----GGTLVVYTAAFDLgipsma---------eildpVAESTVRTNIARVLRG 139 Streptomyces co...
AAP85360     136 rRIVYKQTtlppVLQAHNGEWLVEETGd---GAVRVTARHQVILdpegiaglaeppeslaaardAVREALGANSRATMAR 212 Streptomyces gr...
YP_276430     73 hRIVFQQId--gDLEVWSGEWSIQQAG----DDLSVQLDVLFDLgipsla---------dvlhpIGERAIRANSRQMLEG 137 Pseudomonas syr...
YP_483228    230 rGIVYKQLrlppLASSHHVRWDIEDGG----DHTVVRSIQTVVIng-----------------pGIAELLGASTSLEQAR 288 Frankia sp. CcI3
YP_001510016  75 lTIRFEQTd--gDFDTFSGSWQLAQAG----DDVTVHFEADFDFgipsle---------gildpIAERVIRETVAWAVTG 139 Frankia sp. EAN...
YP_001680511  90 gRIVYRQVs--gDVKRFEGEWRFQATE----GGCHVTLTVDFDLgipmlg---------pllhpLLMKKVRENSRSMLLA 154 Heliobacterium ...
YP_001703015  78 rSIAFEQLs--gDFEIFRGRWLVEPSP----TGSRVSFEVTFDFgipslagv-----lepiaerVLKESIFTIMSRTIAD 146 Mycobacterium a...
ACR15127      82 lGIDFSMVtlppAIASMEGSWAIEPAE----GGARLVVVHDFVPrepga-----------esaaGLAGVLFRTTENVLTM 146 Streptomyces sp...
Feature 1        #      
AAL24453     144 LRRGVED 150 Streptomyces purpurascens
P41178       297 RAPWASQ 303 Streptomyces cinnamonensis
NP_625570    140 LAGAEVI 146 Streptomyces coelicolor A3(2)
AAP85360     213 ARAFAEA 219 Streptomyces griseoruber
YP_276430    138 IRDRILL 144 Pseudomonas syringae pv. phaseolicola 1448A
YP_483228    289 SFIRTEL 295 Frankia sp. CcI3
YP_001510016 140 MFPTTEI 146 Frankia sp. EAN1pec
YP_001680511 155 IKEKIEG 161 Heliobacterium modesticaldum Ice1
YP_001703015 147 VTPVIEE 153 Mycobacterium abscessus
ACR15127     147 LKEWLEA 153 Streptomyces spiramyceticus

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