2ZUO


Conserved Protein Domain Family
MVP_shoulder
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cd08825: MVP_shoulder 
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Shoulder domain of the major vault protein
The major vault protein is the major polypeptide component of a large cellular ribonuclear protein complex found in the cytoplasm of eukaryotic cells. Its shoulder domain appears to be a homolog of the SPFH core domain. Vault proteins may be involved in detoxification processes, and have been associated with the multi-drug resistance (MDR) phenotype in malignancies. Presumably they play a role in transport processes.
Links
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Statistics
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PSSM-Id: 259807
Aligned: 31 rows
Threshold Bit Score: 192.441
Created: 4-Jun-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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oligomer
Conserved site includes 52 residues -Click on image for an interactive view with Cn3D
Feature 1:oligomer interface [polypeptide binding site]
Evidence:
  • Structure:2ZUO: rat liver major vault protein shoulder domain oligomer interface; contacts at 4A
  • Comment:Multimerization of the major vault protein is sufficient to assemble the entire exterior shell of the barrel-shaped vault particle.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   ### #     ## ####     # #                     ##    ##  ##  #  ##  ##
2ZUO_B       509 HARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFELKNrn---dpAEAAKLFSVpDFVGDACKAIASRVRGAVAS 585 Norway rat
EAW79986     509 HARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFEVNDrk---dpQETAKLFSVpDFVGDACKAIGPSTIRDLAV 585 human
XP_001454931 515 NLIQTLTLSLGPDFMTDQLIVETSDHAKLKLTLSYNWHFKVNKdd----pNDAQKLFAVkDFVGDACKSIASRVRGAVSS 590 Paramecium tetr...
CBH15155     524 GHIHSLFLFLGPDFMADKIVVETLEHARLQLEIAYNWEFDTTDv-----eHIKRIAFSVpDFVGMACKTLANRIRAAIAS 598 Trypanosoma bru...
CBH15680     527 SRVNALHLFLGPSNVTDIVHVETRDHAQLALQLCYAWHFDVAHgd----eAAARKCFGVdDFIADACSLIAGRIRAAVAS 602 Trypanosoma bru...
EEY53394     519 NVIRTLCLQLGPDFMRDQIIVETSDHARLSLTIAYNWRFRVDSsk----pVDAAKVFNVkDFTGDACKTLASRIRGAVAV 594 Phytophthora in...
XP_002670013 259 KQIKAAKIMRGPDFVSDSFRVSTKDNAELSILLTYKWEFLVDE-------SDSHVMFRMlDFIGYICATLMSRVRELAAL 331 Naegleria grube...
XP_002680828 281 NSCTIAIVNKGPDFMTDGFLVRTKDNAVLQMELTYKWQFLMSDkkv--sdEEYDKVFSG-DFIGYSCQSLRSRIRELASG 357 Naegleria grube...
CBZ14694     265 HQIHSLCLYLGPDYMADIIEVETRDHARLRLHLAYNWEFGAVAsngkasgVDPELAFAIpDFIGEACKALASRVRSAIAG 344 Leishmania braz...
EJY68804     530 NQIKTLALLLGPDFMTDIIQVETSDHAKLFLRLSYRWTFKVDKtn----eKQCRDLFSVrDFVGDACKRISSRIRGAVSA 605 Oxytricha trifa...

Feature 1          ##  ##  ##                                   #        ### ##  #    ### ### ###
2ZUO_B       586 VTFDDFHK-NSARIIRMAVFGF--EMSEDTGpdgtllpkardqavFPQNGLVVSSVDVQSVEPVD---QRTRDALQRSVQ 659 Norway rat
EAW79986     586 AGPEMQVKlLQSLGLKSTLITD--GSTPINLf-------------NTAFGLLGMGPEGQPLGRRVasgPSPGEGISPQSA 650 human
XP_001454931 591 ITFEDFHN-NSSMKIREAVFGK--EGSEIRTsf-----------tFDANNLVITSVDIQGQEITD---EATRRQLSQSIN 653 Paramecium tetr...
CBH15155     599 EPFDNFHR-NSSSLIRRAIFHShsGTTELRGds----------lyFPVNGLVITNVDVRSVEPVE---VKMQNALTKSVQ 664 Trypanosoma bru...
CBH15680     603 LPFQQFHK-SSVKVLQQAVFGIn-PVNGDPMse----------lrFDANNFVVTSVDTHTMEVLD---PRTREGLQKSVK 667 Trypanosoma bru...
EEY53394     595 QNFDHFHK-HSAQIIRTSIFGLd-ENNKLRDel-----------mFPANNLCITNVDIQSAEPVD---QLTRESLQKSVQ 658 Phytophthora in...
XP_002670013 332 FTFEEFHS-GTVSLIRKHLFNE--SKVNVGNeeksv-----lgiyFDEIKLLVSEIDVKSISPVN---NQINDLLNQSIK 400 Naegleria grube...
XP_002680828 358 HYFESFHK-GAADILRNNLFKD--YKVEFNDetsvq----vhgrlFREFNFFVYAVDVKELRPVD---KEIAQLLDSSIK 427 Naegleria grube...
CBZ14694     345 QTFEFFHC-NSSTLIRQAIFTPaaDGSIVSHgds---------lcFTANGLYITTVDVQSVEPVD---IKTRTALVKSVQ 411 Leishmania braz...
EJY68804     606 VTFDNFHK-NSTEVIQSAVHKQd-EQGNFLPf------------hIQANNLMITQVDIQSIDPVE---EETRKSLQKSVN 668 Oxytricha trifa...

Feature 1        ### ###  # 
2ZUO_B       660 LAIEITTNSQE 670 Norway rat
EAW79986     651 QAPQAPGDNHV 661 human
XP_001454931 654 LAIEISSKSQE 664 Paramecium tetraurelia strain d4-2
CBH15155     665 LAVEIITKSQE 675 Trypanosoma brucei gambiense DAL972
CBH15680     668 IAIEMSTQAQE 678 Trypanosoma brucei gambiense DAL972
EEY53394     659 LAIEITTKSQE 669 Phytophthora infestans T30-4
XP_002670013 401 SNMRIVCNKME 411 Naegleria gruberi strain NEG-M
XP_002680828 428 SSMNIMCNKLQ 438 Naegleria gruberi strain NEG-M
CBZ14694     412 LAVEIITKAQE 422 Leishmania braziliensis MHOM/BR/75/M2904
EJY68804     669 MAFEIQTRSQE 679 Oxytricha trifallax

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