Conserved Protein Domain Family
DED_Caspase_8_r2

?
cd08813: DED_Caspase_8_r2 
Death Effector Domain, repeat 2, of Caspase-8
Death effector domain (DED) found in caspase-8 (CASP8, FLICE), repeat 2. Caspases are aspartate-specific cysteine proteases with functions in apoptosis and immune signaling. Initiator caspases are the first to be activated following death- or inflammation-inducing signals. Caspase-8 is an initiator of death receptor mediated apoptosis. Together with FADD, caspase-10, and the pseudo-caspase c-FLIP, it forms the death-inducing signaling complex (DISC), whose formation is triggered by the activation of type 1 tumor necrosis factor (TNF) receptors such as Fas, TNF receptor 1, and TRAIL receptor. Caspase-8 also plays many important non-apoptotic functions including roles in embryonic development, cell adhesion and motility, immune cell proliferation and differentiation, T-cell activation, and NFkappaB signaling. It contains two N-terminal DED domains and a C-terminal caspase domain. DEDs comprise a subfamily of the Death Domain (DD) superfamily. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and CARD (Caspase activation and recruitment domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Statistics
?
PSSM-Id: 176791
View PSSM: cd08813
Aligned: 4 rows
Threshold Bit Score: 134.545
Threshold Setting Gi: 19401519
Created: 18-Feb-2010
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
putative
Feature 1:putative DED1/DED2 interface [polypeptide binding site]
Evidence:
  • Comment:Based on the structure of the tandem DED domains of v-FLIP.
  • Comment:The tandem DED domains, DED1 and DED2, in FLIP are associated rigidly to form a single compact structure, with each domain playing a unique structural role and is not interchangeable with the other.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1         #  ## ##   #                               #   #                               
AAL87628     157 ISAYRVMLYQISEEVSRSELRSFKFLLqeEISKCKLDDdm--nLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKII 234 human
XP_002190143  99 VPPFRYLLFQLFEDVTEDELMSFKLLLvnELPKSKLTRet--tMLDILTEMEKKGLLGKDNLSMLKSLCEKINISLWNRI 176 zebra finch
XP_001513568  98 VSAYRVLLFTLSDNVTREELKSITFFLsnDLPRSRLDNkvsstLMGIFIEMEKKGILGESNLDMLKKICDKIDKTLLGKI 177 platypus
NP_989923     98 VSPFRYLLFQLSENITKDDMKCFKFLLgkELPKCKLSPet--tMPDVFIEMEKKGILKEDNLTVLKTICGKVDKSLLKKI 175 chicken
Feature 1             
AAL87628     235 NDYEE 239 human
XP_002190143 177 EDGLK 181 zebra finch
XP_001513568 178 DHYEE 182 platypus
NP_989923    176 EDYEL 180 chicken

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap