1WMG,1WMG,3G5B


Conserved Protein Domain Family
Death_UNC5B

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cd08802: Death_UNC5B 
Click on image for an interactive view with Cn3D
Death domain found in Uncoordinated-5B
Death Domain (DD) found in Uncoordinated-5B (UNC5B). UNC5B is part of the UNC-5 homolog family. It is a receptor for the secreted netrin-1 and plays a role in axonal guidance, angiogenesis, and apoptosis. UNC5B signaling is involved in the netrin-1-induced proliferation and migration of renal proximal tubular cells. It is also required for vascular patterning during embryonic development, and its activation inhibits sprouting angiogenesis. UNC5 proteins are transmembrane proteins with an extracellular domain consisting of two immunoglobulin repeats, two thrombospondin type-I modules and an intracellular region containing a ZU-5 domain, UPA domain and a DD. In general, DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD (Caspase activation and recruitment domain), DED (Death Effector Domain), and PYRIN. They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Statistics
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PSSM-Id: 176780
View PSSM: cd08802
Aligned: 6 rows
Threshold Bit Score: 164.81
Threshold Setting Gi: 60593887
Created: 18-Feb-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
dimer interface
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                      ## ##         #  ##  ##                        
1WMG_A     12 IPLSIRQKICSSLDapnsrgNDWRLLAQKLSXDRYLNYFATKaSPTGVILDLWEARQQddgDLNSLASALEEXGKSEXLV 91   house mouse
1WMG_B     12 IPLSIRQKICSSLDapnsrgNDWRLLAQKLSXDRYLNYFATKaSPTGVILDLWEARQQddgDLNSLASALEEXGKSEXLV 91   house mouse
3G5B_A    318 IPLSIRQKICNSLDapnsrgNDWRLLAQKLSMDRYLNYFATKaSPTGVILDLWEARQQddgDLNSLASALEEMGKSEMLV 397  Norway rat
AAM34486  856 IPFSIRQKICNSLDapnsrgNDWRLLAQKLCMDRYLNYFATKaSPTGVILDLWEALHQddgDLNTLASALEEMGKSEMML 935  African clawed frog
AAI63521  853 LPVSIRQKICASLDapsargCDWRMLARSLAFDRYLNYFATKpSPTGVLLDLWEACHQgdaDLVSLATALEEMGKSEVLV 932  zebrafish
AAQ02790  858 IPLSIRQKICNSLDapnsrgNDWRLLAQKLSMDRYLNYFATKaSPTGVILDLWEAEHQddgDLNTLASALEEMGKSEMLV 937  chicken
Feature 1         
1WMG_A     92 AXAT 95   house mouse
1WMG_B     92 AXAT 95   house mouse
3G5B_A    398 AMTT 401  Norway rat
AAM34486  936 VMAT 939  African clawed frog
AAI63521  933 VMTT 936  zebrafish
AAQ02790  938 VMAT 941  chicken

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