Conserved Protein Domain Family
Death_UNC5D

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cd08801: Death_UNC5D 
Death domain found in Uncoordinated-5D
Death Domain (DD) found in Uncoordinated-5D (UNC5D). UNC5D is part of the UNC-5 homolog family. It is a receptor for the secreted netrin-1 and plays a role in axonal guidance, angiogenesis, and apoptosis. UNC5 proteins are transmembrane proteins with an extracellular domain consisting of two immunoglobulin repeats, two thrombospondin type-I modules and an intracellular region containing a ZU-5 domain, UPA domain and a DD. In general, DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD (Caspase activation and recruitment domain), DED (Death Effector Domain), and PYRIN. They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Statistics
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PSSM-Id: 176779
View PSSM: cd08801
Aligned: 3 rows
Threshold Bit Score: 196.815
Threshold Setting Gi: 81230840
Created: 18-Feb-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:based on the structure of UNC5B DD homodimer

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                      ## ##         #  ##  ##                        
EAW63382  824 IPYSIRQRICATFDtpnakgKDWQMLAQKNSINRNLSYFATQsSPSAVILNLWEARhqhDGDLDSLACALEEIGRTHTKL 903  human
ABB59711  822 IPQSIRQRICATFDtanakgKDWQLLAQKLHIDRNLGYFARQtSPSAVILSLWEAQhqeQGDLDSLASALEEIGKVQSKQ 901  zebrafish
XP_424529 830 IPYSIRQRICATFDtpnakgKDWQMLAQKNSISRNLSYFATQsSPSAVILDLWEARhqhDGDLDSLACALEEIGRTHSKI 909  chicken
Feature 1                       
EAW63382  904 SNISESQLDEADFNYSRQ 921  human
ABB59711  902 STSADTLDRISKTIPSSD 919  zebrafish
XP_424529 910 SDITETEIEEPDFNYSRQ 927  chicken

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