3MOP,3MOP


Conserved Protein Domain Family
Death_IRAK2

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cd08795: Death_IRAK2 
Click on image for an interactive view with Cn3D
Death domain of Interleukin 1 Receptor Associated Kinase-2
Death Domain (DD) of Interleukin-1 Receptor-Associated Kinase 1 (IRAK1). IRAKs are essential components of innate immunity and inflammation in mammals and other vertebrates. They are involved in signal transduction pathways involving IL-1 and IL-18 receptors, Toll-like receptors (TLRs), nuclear factor-kappaB (NF-kB), and mitogen-activated protein kinases (MAPKs). IRAKs contain an N-terminal DD domain and a C-terminal kinase domain. IRAK2 is an essential component of several signaling pathways, including NF-kappaB and the IL-1 signaling pathways. It is an inactive kinase that participates in septic shock mediated by TLR4 and TLR9. It plays a redundant role with IRAK1 in early NF-kB and MAPK responses, and remains present at later stages whereas IRAK1 disappears. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD (Caspase activation and recruitment domain), DED (Death Effector Domain), and PYRIN. They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Statistics
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PSSM-Id: 176773
View PSSM: cd08795
Aligned: 4 rows
Threshold Bit Score: 153.543
Threshold Setting Gi: 297343147
Created: 18-Feb-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
IRAK2-IRAK4
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:IRAK2-IRAK4 interaction site [polypeptide binding site]
Evidence:
  • Structure:3MOP; Four IRAK2 DDs interact with four IRAK4 DDs within the Myddosome complex; contacts at 4A.
    View structure with Cn3D
  • Comment:MyD88, IRAK4, and IRAK2 form the Myddosome complex which is assembled in a stepwise manner. MyD88 first recruits IRAK4, then the MyD88-IRAK4 complex recruits the substrates IRAK2 or IRAK1.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          ## ####                                #       ##    ##  #######    #         
3MOP_K         2 CYIYQLPSWVLDDLCRNMDAlseWDWMEFASYVITDLTQLRKIKSMEWvQGVSITRELLWWWGMRQATVQQLVDLLCRLE 81  human
3MOP_L         2 CYIYQLPSWVLDDLCRNMDAlseWDWMEFASYVITDLTQLRKIKSMEWvQGVSITRELLWWWGMRQATVQQLVDLLCRLE 81  human
NP_001025776  17 PYVHSMPAWVLEDFCQKMDClsdSDWMRFASYVITDQTELRKIKCMEK-TGISITRELMWWWGVRLATVRQLLDLLQALQ 95  chicken
AAH43819      11 PCVFDIPAKTMDEFCRCMDSlsdWEWMRFASSVIDDQTVLRRIRSYER-TGVSVTGELMWSWGQKLPTLQELVDRLQKLE 89  African clawed ...
Feature 1                 
3MOP_K        82 LYRAAQIIL 90  human
3MOP_L        82 LYRAAQIIL 90  human
NP_001025776  96 LYRAAQVIL 104 chicken
AAH43819      90 LYRALGILQ 98  African clawed frog

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