Conserved Protein Domain Family
DED_DEDD2

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cd08791: DED_DEDD2 
Death Effector Domain of DEDD2
Death Effector Domain (DED) found in DEDD2. DEDD2 has been shown to bind to itself, DEDD, and to the two tandem DED-containing caspases, caspase-8 and -10. It may play a role in apoptosis. In general, DEDs comprise a subfamily of the Death Domain (DD) superfamily. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and CARD (Caspase activation and recruitment domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes. In mammals, they are prominent components of the programmed cell death (apoptosis) pathway and are found in a number of other signaling pathways.
Statistics
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PSSM-Id: 176769
View PSSM: cd08791
Aligned: 3 rows
Threshold Bit Score: 178.885
Threshold Setting Gi: 18858537
Created: 18-Feb-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
charge triad
Feature 1: charge triad [active site], 3 residue positions
Conserved feature residue pattern:[ED] R DClick to see conserved feature residue pattern help
Evidence:
  • Comment:The charge triad is part of a signature motif (E/D-RxDL) that is present in the DED family but not in other families of death domains (DD, CARD or Pyrin).
  • Comment:The charge triad is essential for the function of some DED-containing proteins. In FLIP, it is involved in the interaction with FADD to block apoptosis. In PEA15, the triad is necessary for interaction with ERK MAP kinase.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                   #                                                    
NP_001085793  15 EDECLEYYGMLSLHRMFDVVGSQLTQNDIDVLSFLLhETHPFTHPLDpqlwtaeeeageampnsalls---awqrwnrgs 91  African clawed ...
EAW57110      26 EDECLDYYGMLSLHRMFEVVGGQLTECELELLAFLLdEAPGAAGGLA--------------------------------- 72  human
NP_571677     15 ETECLSYYETLSLHEIFEIVGSQLTETCGGEVAFLLdETYPGKHPLDpegwtedlppgpdgspqantpcprllkswqrmq 94  zebrafish
Feature 1                                                      # #                      
NP_001085793  92 rtlnnldspdllRPKDGTELLLELERRGKCDESNFTHLLQLLRVLTRHDLLPYVTTKRPRAVSPERYTYGP 162 African clawed frog
EAW57110      73 ------------RARSGLELLLELERRGQCDESNLRLLGQLLRVLARHDLLPHLARKRRRPVSPERYSYGT 131 human
NP_571677     95 pqkegcsiasrhRPKSGVELLLELERRGYLSDANLRPLLQLLRILTRHDVLPFVSQKKRRTVSPERQKIDY 165 zebrafish

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